(6 nodes) Mixed, incl. Tie signaling pathway, and C-terminal of Roc, COR, domain network (Ailuropoda melanoleuca)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TIE1	Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1138 aa)
	TEK	TEK receptor tyrosine kinase. (1127 aa)
	ANGPT2	Angiopoietin 2. (496 aa)
	ANGPT4	Angiopoietin 4. (495 aa)
	LRRK1	Leucine rich repeat kinase 1. (1982 aa)
	ANGPT1	Angiopoietin 1. (410 aa)

Your Current Organism:

Ailuropoda melanoleuca

NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANGPT1	ANGPT2	ENSAMEP00000016438	ENSAMEP00000005606	Angiopoietin 1.	Angiopoietin 2.	0.900
ANGPT1	ANGPT4	ENSAMEP00000016438	ENSAMEP00000014878	Angiopoietin 1.	Angiopoietin 4.	0.903
ANGPT1	TEK	ENSAMEP00000016438	ENSAMEP00000001894	Angiopoietin 1.	TEK receptor tyrosine kinase.	0.999
ANGPT1	TIE1	ENSAMEP00000016438	ENSAMEP00000001831	Angiopoietin 1.	Tyrosine kinase with immunoglobulin like and EGF like domains 1.	0.938
ANGPT2	ANGPT1	ENSAMEP00000005606	ENSAMEP00000016438	Angiopoietin 2.	Angiopoietin 1.	0.900
ANGPT2	ANGPT4	ENSAMEP00000005606	ENSAMEP00000014878	Angiopoietin 2.	Angiopoietin 4.	0.901
ANGPT2	TEK	ENSAMEP00000005606	ENSAMEP00000001894	Angiopoietin 2.	TEK receptor tyrosine kinase.	0.878
ANGPT2	TIE1	ENSAMEP00000005606	ENSAMEP00000001831	Angiopoietin 2.	Tyrosine kinase with immunoglobulin like and EGF like domains 1.	0.667
ANGPT4	ANGPT1	ENSAMEP00000014878	ENSAMEP00000016438	Angiopoietin 4.	Angiopoietin 1.	0.903
ANGPT4	ANGPT2	ENSAMEP00000014878	ENSAMEP00000005606	Angiopoietin 4.	Angiopoietin 2.	0.901
ANGPT4	TEK	ENSAMEP00000014878	ENSAMEP00000001894	Angiopoietin 4.	TEK receptor tyrosine kinase.	0.993
ANGPT4	TIE1	ENSAMEP00000014878	ENSAMEP00000001831	Angiopoietin 4.	Tyrosine kinase with immunoglobulin like and EGF like domains 1.	0.798
LRRK1	TIE1	ENSAMEP00000015101	ENSAMEP00000001831	Leucine rich repeat kinase 1.	Tyrosine kinase with immunoglobulin like and EGF like domains 1.	0.824
TEK	ANGPT1	ENSAMEP00000001894	ENSAMEP00000016438	TEK receptor tyrosine kinase.	Angiopoietin 1.	0.999
TEK	ANGPT2	ENSAMEP00000001894	ENSAMEP00000005606	TEK receptor tyrosine kinase.	Angiopoietin 2.	0.878
TEK	ANGPT4	ENSAMEP00000001894	ENSAMEP00000014878	TEK receptor tyrosine kinase.	Angiopoietin 4.	0.993
TEK	TIE1	ENSAMEP00000001894	ENSAMEP00000001831	TEK receptor tyrosine kinase.	Tyrosine kinase with immunoglobulin like and EGF like domains 1.	0.507
TIE1	ANGPT1	ENSAMEP00000001831	ENSAMEP00000016438	Tyrosine kinase with immunoglobulin like and EGF like domains 1.	Angiopoietin 1.	0.938
TIE1	ANGPT2	ENSAMEP00000001831	ENSAMEP00000005606	Tyrosine kinase with immunoglobulin like and EGF like domains 1.	Angiopoietin 2.	0.667
TIE1	ANGPT4	ENSAMEP00000001831	ENSAMEP00000014878	Tyrosine kinase with immunoglobulin like and EGF like domains 1.	Angiopoietin 4.	0.798