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EXOSC1 EXOSC1 RRP12 RRP12 NSA2 NSA2 GNL2 GNL2 HEATR1 HEATR1 UTP11 UTP11 NOM1 NOM1 G1L3W6_AILME G1L3W6_AILME DCAF13 DCAF13 NMD3 NMD3 WDR46 WDR46 EBNA1BP2 EBNA1BP2 GTPBP4 GTPBP4 SKIV2L SKIV2L TSR2 TSR2 GNL3L GNL3L RCL1 RCL1 MAK16 MAK16 IMP4 IMP4 MRTO4 MRTO4 PMEL PMEL FTSJ3 FTSJ3 DIS3L DIS3L BRIX1 BRIX1 PA2G4 PA2G4 DDX31 DDX31 DIMT1 DIMT1 G1LC61_AILME G1LC61_AILME WDR3 WDR3 GCC1 GCC1 RBM28 RBM28 C1D C1D PNO1 PNO1 EXOSC3 EXOSC3 NIFK NIFK WDR43 WDR43 UTP6 UTP6 BOP1 BOP1 DHX33 DHX33 EXOSC4 EXOSC4 G1LHT4_AILME G1LHT4_AILME EXOSC9 EXOSC9 WDR74 WDR74 KRR1 KRR1 TENT4B TENT4B NOB1 NOB1 FBLL1 FBLL1 NEXN NEXN DHX32 DHX32 NOL6 NOL6 PES1 PES1 NIP7 NIP7 TSR1 TSR1 UTP4 UTP4 PELO PELO NAT10 NAT10 UTP18 UTP18 GNL3 GNL3 RPF1 RPF1 RBM19 RBM19 DDX54 DDX54 WDR17 WDR17 ESF1 ESF1 RBM34 RBM34 RTCA RTCA IPO8 IPO8 DDX10 DDX10 RRP9 RRP9 LSG1 LSG1 RRP7A RRP7A RSL1D1 RSL1D1 EXOSC10 EXOSC10 DNTTIP2 DNTTIP2 EIF6 EIF6 HBS1L HBS1L TDRD12 TDRD12 ZCCHC7 ZCCHC7 G1LUA7_AILME G1LUA7_AILME NOL12 NOL12 UTP23 UTP23 ZNF593 ZNF593 TTC37 TTC37 DDX47 DDX47 RRP15 RRP15 PWP2 PWP2 NOP56 NOP56 METTL27 METTL27 KRI1 KRI1 RRP1B RRP1B RRP1 RRP1 NOL10 NOL10 LTV1 LTV1 UTP15 UTP15 ABT1 ABT1 DDX49 DDX49 EXOSC5 EXOSC5 SDAD1 SDAD1 SURF6 SURF6 G1LZY0_AILME G1LZY0_AILME EXOSC7 EXOSC7 WDR75 WDR75 PUM3 PUM3 DIS3 DIS3 MCC MCC WDR61 WDR61 DDX18 DDX18 FBL FBL RPL7L1 RPL7L1 WDR36 WDR36 NSUN6 NSUN6 BYSL BYSL WDR12 WDR12 DDX52 DDX52 NOP58 NOP58 RBM7 RBM7 G1M3Z0_AILME G1M3Z0_AILME DDX60 DDX60 AATF AATF NOC3L NOC3L LYAR LYAR NOC4L NOC4L DDX27 DDX27 DDX51 DDX51 EMG1 EMG1 RIOK3 RIOK3 GLMN GLMN MTREX MTREX MPHOSPH6 MPHOSPH6 NOP2 NOP2 NOP14 NOP14 RIOK2 RIOK2 NLE1 NLE1 ZCCHC8 ZCCHC8 G1M8W1_AILME G1M8W1_AILME GRWD1 GRWD1 UTP14A UTP14A NOP53 NOP53 DDX55 DDX55 MPHOSPH10 MPHOSPH10 TDRD12-2 TDRD12-2 DHX37 DHX37 SNU13 SNU13 EXOSC8 EXOSC8 RPF2 RPF2 DDX24 DDX24 DHX57 DHX57 PINX1 PINX1 NOP9 NOP9 PWP1 PWP1 EXOSC2 EXOSC2 RRP8 RRP8 UTP20 UTP20 NOC2L NOC2L NGDN NGDN BMS1 BMS1 KCTD19 KCTD19 CEBPZ CEBPZ TBL3 TBL3 DDX56 DDX56 PDCD11 PDCD11 UTP25 UTP25 FCF1 FCF1 RSL24D1 RSL24D1 NOL11 NOL11 EXOSC6 EXOSC6 IMP3 IMP3 UTP3 UTP3 P2RY11 P2RY11 DDX53 DDX53
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EXOSC1Exosome component 1. (195 aa)
RRP12Ribosomal RNA processing 12 homolog. (1298 aa)
NSA2NSA2 ribosome biogenesis factor. (259 aa)
GNL2Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. (730 aa)
HEATR1HEAT repeat containing 1. (2140 aa)
UTP11U3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA. (253 aa)
NOM1Nucleolar protein with MIF4G domain 1. (722 aa)
G1L3W6_AILMEUncharacterized protein. (156 aa)
DCAF13DDB1 and CUL4 associated factor 13. (447 aa)
NMD360S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family. (505 aa)
WDR46WD repeat domain 46. (615 aa)
EBNA1BP2EBNA1 binding protein 2. (311 aa)
GTPBP4Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (634 aa)
SKIV2LSki2 like RNA helicase. (1245 aa)
TSR2TSR2 ribosome maturation factor. (189 aa)
GNL3LG protein nucleolar 3 like. (581 aa)
RCL1RNA terminal phosphate cyclase like 1. (373 aa)
MAK16Protein MAK16 homolog; Belongs to the MAK16 family. (299 aa)
IMP4IMP U3 small nucleolar ribonucleoprotein 4. (290 aa)
MRTO4Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (239 aa)
PMELPremelanosome protein. (673 aa)
FTSJ3FtsJ RNA 2'-O-methyltransferase 3. (831 aa)
DIS3LDIS3 like exosome 3'-5' exoribonuclease. (1023 aa)
BRIX1Biogenesis of ribosomes BRX1. (353 aa)
PA2G4Proliferation-associated 2G4. (402 aa)
DDX31RNA helicase. (726 aa)
DIMT1rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (313 aa)
G1LC61_AILMEProtein SDA1; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family. (429 aa)
WDR3WD repeat domain 3. (943 aa)
GCC1GRIP and coiled-coil domain containing 1. (776 aa)
RBM28RNA binding motif protein 28. (820 aa)
C1DC1D nuclear receptor corepressor. (146 aa)
PNO1Partner of NOB1 homolog. (252 aa)
EXOSC3Exosome component 3. (275 aa)
NIFKNucleolar protein interacting with the FHA domain of MKI67. (297 aa)
WDR43WD repeat domain 43. (699 aa)
UTP6UTP6 small subunit processome component. (598 aa)
BOP1Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (703 aa)
DHX33DEAH-box helicase 33. (678 aa)
EXOSC4Exosome component 4. (245 aa)
G1LHT4_AILME40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (239 aa)
EXOSC9Exosome component 9. (440 aa)
WDR74WD repeat domain 74. (388 aa)
KRR1KRR1 small subunit processome component; Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. (380 aa)
TENT4BTerminal nucleotidyltransferase 4B. (675 aa)
NOB1RNA-binding protein NOB1; May play a role in mRNA degradation. Belongs to the NOB1 family. (421 aa)
FBLL1Fibrillarin like 1. (260 aa)
NEXNNexilin F-actin binding protein. (676 aa)
DHX32DEAH-box helicase 32 (putative). (752 aa)
NOL6Nucleolar protein 6. (1158 aa)
PES1Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the pescadillo family. (589 aa)
NIP7Nucleolar pre-rRNA processing protein NIP7. (180 aa)
TSR1TSR1 ribosome maturation factor. (819 aa)
UTP4UTP4 small subunit processome component. (686 aa)
PELOProtein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (385 aa)
NAT10RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1026 aa)
UTP18UTP18 small subunit processome component. (559 aa)
GNL3G protein nucleolar 3. (550 aa)
RPF1Ribosome production factor 1 homolog. (229 aa)
RBM19RNA binding motif protein 19. (959 aa)
DDX54ATP-dependent RNA helicase DDX54; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily. (880 aa)
WDR17WD repeat domain 17. (1292 aa)
ESF1ESF1 nucleolar pre-rRNA processing protein homolog. (850 aa)
RBM34Uncharacterized protein. (428 aa)
RTCARNA 3'-terminal phosphate cyclase. (269 aa)
IPO8Importin 8. (1040 aa)
DDX10RNA helicase. (870 aa)
RRP9Ribosomal RNA processing 9, U3 small nucleolar RNA binding protein. (477 aa)
LSG1Large 60S subunit nuclear export GTPase 1. (660 aa)
RRP7ARibosomal RNA processing 7 homolog A. (280 aa)
RSL1D1Ribosomal L1 domain containing 1. (493 aa)
EXOSC10Exosome component 10. (887 aa)
DNTTIP2Deoxynucleotidyltransferase terminal interacting protein 2. (774 aa)
EIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (245 aa)
HBS1LHBS1 like translational GTPase. (685 aa)
TDRD12Tudor domain containing 12. (255 aa)
ZCCHC7CCHC-type domain-containing protein. (260 aa)
G1LUA7_AILMECCHC-type domain-containing protein. (220 aa)
NOL12Uncharacterized protein. (213 aa)
UTP23UTP23 small subunit processome component. (248 aa)
ZNF593Zinc finger protein 593. (156 aa)
TTC37Tetratricopeptide repeat domain 37. (1485 aa)
DDX47DEAD-box helicase 47; Belongs to the DEAD box helicase family. (455 aa)
RRP15Ribosomal RNA processing 15 homolog. (284 aa)
PWP2Uncharacterized protein. (911 aa)
NOP56NOP56 ribonucleoprotein. (597 aa)
METTL27Methyltransferase like 27. (240 aa)
KRI1KRI1 homolog. (718 aa)
RRP1BRibosomal RNA processing 1B. (727 aa)
RRP1Ribosomal RNA processing 1. (454 aa)
NOL10Nucleolar protein 10. (688 aa)
LTV1LTV1 ribosome biogenesis factor. (474 aa)
UTP15UTP15 small subunit processome component. (519 aa)
ABT1Activator of basal transcription 1. (269 aa)
DDX49DEAD-box helicase 49; Belongs to the DEAD box helicase family. (483 aa)
EXOSC5Exosome component 5. (235 aa)
SDAD1Protein SDA1; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family. (687 aa)
SURF6Surfeit 6. (368 aa)
G1LZY0_AILMEBrix domain-containing protein. (462 aa)
EXOSC7Exosome component 7. (290 aa)
WDR75WD repeat domain 75. (834 aa)
PUM3Pumilio RNA binding family member 3. (647 aa)
DIS3DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease; Belongs to the RNR ribonuclease family. (958 aa)
MCCMCC regulator of WNT signaling pathway. (826 aa)
WDR61WD repeat domain 61. (305 aa)
DDX18RNA helicase. (671 aa)
FBLFibrillarin. (345 aa)
RPL7L1Ribosomal protein L7 like 1. (247 aa)
WDR36WD repeat domain 36. (946 aa)
NSUN6NOP2/Sun RNA methyltransferase 6; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (469 aa)
BYSLBystin like. (437 aa)
WDR12Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (423 aa)
DDX52DExD-box helicase 52. (598 aa)
NOP58NOP58 ribonucleoprotein. (539 aa)
RBM7RRM domain-containing protein. (263 aa)
G1M3Z0_AILMENLE domain-containing protein. (407 aa)
DDX60DExD/H-box helicase 60. (1711 aa)
AATFApoptosis antagonizing transcription factor. (558 aa)
NOC3LNucleolar complex protein 3 homolog. (799 aa)
LYARLy1 antibody reactive. (387 aa)
NOC4LNucleolar complex associated 4 homolog. (507 aa)
DDX27DEAD-box helicase 27; Belongs to the DEAD box helicase family. (780 aa)
DDX51DEAD-box helicase 51; Belongs to the DEAD box helicase family. (552 aa)
EMG1EMG1 N1-specific pseudouridine methyltransferase. (244 aa)
RIOK3Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. (610 aa)
GLMNGlomulin, FKBP associated protein. (600 aa)
MTREXMtr4 exosome RNA helicase. (1043 aa)
MPHOSPH6M-phase phosphoprotein 6. (161 aa)
NOP2SAM_MT_RSMB_NOP domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (829 aa)
NOP14NOP14 nucleolar protein. (827 aa)
RIOK2RIO kinase 2. (551 aa)
NLE1Notchless homolog 1. (486 aa)
ZCCHC8Zinc finger CCHC-type containing 8. (712 aa)
G1M8W1_AILMEUncharacterized protein. (202 aa)
GRWD1Glutamate rich WD repeat containing 1. (447 aa)
UTP14AUncharacterized protein. (785 aa)
NOP53NOP53 ribosome biogenesis factor. (493 aa)
DDX55RNA helicase. (600 aa)
MPHOSPH10M-phase phosphoprotein 10. (679 aa)
TDRD12-2Uncharacterized protein. (818 aa)
DHX37DEAH-box helicase 37. (1149 aa)
SNU13Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (127 aa)
EXOSC8Exosome component 8. (276 aa)
RPF2Ribosome production factor 2 homolog. (303 aa)
DDX24DEAD-box helicase 24. (853 aa)
DHX57DExH-box helicase 57. (1386 aa)
PINX1PIN2 (TERF1) interacting telomerase inhibitor 1. (433 aa)
NOP9NOP9 nucleolar protein. (638 aa)
PWP1PWP1 homolog, endonuclein. (500 aa)
EXOSC2Exosome component 2. (293 aa)
RRP8Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] (504 aa)
UTP20UTP20 small subunit processome component. (2794 aa)
NOC2LNOC2 like nucleolar associated transcriptional repressor. (744 aa)
NGDNNeuroguidin. (318 aa)
BMS1BMS1 ribosome biogenesis factor. (1285 aa)
KCTD19Potassium channel tetramerization domain containing 19. (924 aa)
CEBPZCCAAT enhancer binding protein zeta. (1064 aa)
TBL3Transducin beta like 3. (802 aa)
DDX56DEAD-box helicase 56. (545 aa)
PDCD11Programmed cell death 11. (1877 aa)
UTP25UTP25 small subunit processor component. (767 aa)
FCF1PINc domain-containing protein. (198 aa)
RSL24D1Ribosomal L24 domain containing 1. (163 aa)
NOL11Nucleolar protein 11. (647 aa)
EXOSC6Uncharacterized protein. (91 aa)
IMP3IMP U3 small nucleolar ribonucleoprotein 3. (184 aa)
UTP3UTP3 small subunit processome component. (475 aa)
P2RY11Purinergic receptor P2Y11. (362 aa)
DDX53Uncharacterized protein; Belongs to the DEAD box helicase family. (610 aa)
Your Current Organism:
Ailuropoda melanoleuca
NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda
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