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| | TDRD3 | Tudor domain containing 3. (746 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1867 aa) |
| | CETN2 | Centrin 2. (172 aa) |
| | CDT1 | Chromatin licensing and DNA replication factor 1. (526 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1518 aa) |
| | CDC7 | Cell division cycle 7. (578 aa) |
| | G1L0X7_AILME | Uncharacterized protein. (1218 aa) |
| | FANCE | FA complementation group E. (491 aa) |
| | SMUG1 | Single-strand-selective monofunctional uracil-DNA glycosylase 1. (272 aa) |
| | CLSPN | Claspin. (1338 aa) |
| | POLD4 | Uncharacterized protein. (121 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (394 aa) |
| | POLK | DNA polymerase kappa. (871 aa) |
| | RFC4 | Replication factor C subunit 4. (365 aa) |
| | ATRIP | ATR interacting protein. (786 aa) |
| | DBF4 | DBF4-type domain-containing protein. (681 aa) |
| | FANCA | FA complementation group A. (1451 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (729 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (863 aa) |
| | WRN | 3'-5' exonuclease domain-containing protein. (268 aa) |
| | FBH1 | F-box DNA helicase 1. (1048 aa) |
| | FANCM | FA complementation group M. (2048 aa) |
| | DSCC1 | DNA replication and sister chromatid cohesion 1. (393 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (904 aa) |
| | GINS4 | GINS complex subunit 4. (223 aa) |
| | VWA5B1 | Von Willebrand factor A domain containing 5B1. (1248 aa) |
| | RAD17 | RAD17 checkpoint clamp loader component. (682 aa) |
| | RFC1 | Replication factor C subunit 1. (1133 aa) |
| | RAD1 | RAD1 checkpoint DNA exonuclease. (282 aa) |
| | MGMT | O-6-methylguanine-DNA methyltransferase. (187 aa) |
| | MCM9 | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1141 aa) |
| | APEX2 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (516 aa) |
| | RNF168 | Ring finger protein 168. (569 aa) |
| | TM4SF19 | Uncharacterized protein. (214 aa) |
| | BARD1 | BRCA1 associated RING domain 1. (736 aa) |
| | TIMELESS | Timeless circadian regulator. (1207 aa) |
| | PRIM1 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (419 aa) |
| | RAD52 | RAD52 homolog, DNA repair protein. (423 aa) |
| | XRCC1 | X-ray repair cross complementing 1. (643 aa) |
| | ORC3 | Origin recognition complex subunit 3. (726 aa) |
| | MBD4 | Methyl-CpG-binding domain protein 4; Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. (569 aa) |
| | XPA | XPA, DNA damage recognition and repair factor. (266 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (268 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (959 aa) |
| | RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (241 aa) |
| | HELQ | Helicase, POLQ like. (1004 aa) |
| | GINS1 | Uncharacterized protein. (87 aa) |
| | POLB | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa) |
| | CLIP4 | CAP-Gly domain containing linker protein family member 4. (705 aa) |
| | PRIM2 | Uncharacterized protein. (276 aa) |
| | APEX1 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa) |
| | RECQL4 | RecQ like helicase 4. (1203 aa) |
| | ATAD5 | ATPase family AAA domain containing 5. (1851 aa) |
| | ORC5 | Origin recognition complex subunit 5. (435 aa) |
| | RAD54B | Uncharacterized protein. (911 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (822 aa) |
| | ORC2 | Origin recognition complex subunit 2. (578 aa) |
| | NEIL2 | Nei like DNA glycosylase 2. (326 aa) |
| | DZIP1L | DAZ interacting zinc finger protein 1 like. (774 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa) |
| | MSH6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1364 aa) |
| | FANCB | FA complementation group B. (867 aa) |
| | G1LID4_AILME | DNA_MISMATCH_REPAIR_2 domain-containing protein. (367 aa) |
| | MPG | N-methylpurine DNA glycosylase. (286 aa) |
| | G1LJV2_AILME | Uncharacterized protein. (158 aa) |
| | CHTF18 | Chromosome transmission fidelity factor 18. (1114 aa) |
| | HUS1B | Checkpoint protein; Belongs to the HUS1 family. (272 aa) |
| | TOP3B | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (862 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (712 aa) |
| | G1LMA1_AILME | Uncharacterized protein. (417 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (619 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1060 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (562 aa) |
| | NEIL1 | Nei like DNA glycosylase 1. (387 aa) |
| | EME2 | Essential meiotic structure-specific endonuclease subunit 2. (320 aa) |
| | MEIOB | Meiosis specific with OB-fold. (472 aa) |
| | CHEK2 | Checkpoint kinase 2. (545 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (845 aa) |
| | BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (1250 aa) |
| | PMS2 | PMS1 homolog 2, mismatch repair system component. (870 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | MSH5 | MUTSd domain-containing protein. (486 aa) |
| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (860 aa) |
| | XPC | XPC complex subunit, DNA damage recognition and repair factor. (945 aa) |
| | BRCA2 | BRCA2 DNA repair associated. (3460 aa) |
| | POLE2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa) |
| | G1LSP1_AILME | Uncharacterized protein. (271 aa) |
| | MAD2L2 | Mitotic arrest deficient 2 like 2. (211 aa) |
| | MCMBP | Minichromosome maintenance complex binding protein. (647 aa) |
| | ERCC6 | ERCC excision repair 6, chromatin remodeling factor. (1481 aa) |
| | MCM8 | MCM domain-containing protein; Belongs to the MCM family. (835 aa) |
| | DMC1 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (342 aa) |
| | SLX4 | SLX4 structure-specific endonuclease subunit. (1574 aa) |
| | USP7 | Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1112 aa) |
| | HLTF | Helicase like transcription factor. (1010 aa) |
| | RPA2 | Replication protein A2. (231 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (913 aa) |
| | REV3L | REV3 like, DNA directed polymerase zeta catalytic subunit. (3129 aa) |
| | CDC45 | Cell division cycle 45. (602 aa) |
| | FANCC | FA complementation group C. (557 aa) |
| | EME1 | Essential meiotic structure-specific endonuclease 1. (576 aa) |
| | UBE2T | Ubiquitin conjugating enzyme E2 T; Belongs to the ubiquitin-conjugating enzyme family. (197 aa) |
| | POLH | DNA polymerase eta. (712 aa) |
| | PMS1 | PMS1 homolog 1, mismatch repair system component. (930 aa) |
| | RAD18 | RAD18 E3 ubiquitin protein ligase. (569 aa) |
| | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (298 aa) |
| | MCMDC2 | Minichromosome maintenance domain containing 2. (681 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa) |
| | POLE3 | DNA polymerase epsilon 3, accessory subunit. (147 aa) |
| | FANCI | FA complementation group I. (1102 aa) |
| | G1M338_AILME | ENDO3c domain-containing protein. (219 aa) |
| | MDC1 | Mediator of DNA damage checkpoint 1. (1952 aa) |
| | POLD1 | DNA polymerase. (1105 aa) |
| | REV1 | DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1252 aa) |
| | XRCC2 | X-ray repair cross complementing 2. (279 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa) |
| | MCM10 | Minichromosome maintenance 10 replication initiation factor. (894 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2288 aa) |
| | MUTYH | Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (548 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (903 aa) |
| | BLM | BLM RecQ like helicase. (1412 aa) |
| | RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (421 aa) |
| | EXO1 | Exonuclease 1. (845 aa) |
| | RAD54L | RAD54 like. (747 aa) |
| | PALB2 | Partner and localizer of BRCA2. (1179 aa) |
| | POLN | DNA polymerase nu. (865 aa) |
| | RAD51B | RAD51 paralog B. (253 aa) |
| | PANDA_005237 | Rad51 domain-containing protein. (59 aa) |
| | RCHY1 | Ring finger and CHY zinc finger domain containing 1. (261 aa) |
| | WDHD1 | WD repeat and HMG-box DNA binding protein 1. (1128 aa) |
| | LIG3 | DNA ligase. (1014 aa) |
| | RAD51D | RAD51 paralog D. (303 aa) |
| | G1M863_AILME | Uncharacterized protein. (85 aa) |
| | POLA1 | DNA polymerase. (1466 aa) |
| | POLQ | DNA polymerase theta. (2630 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (903 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (769 aa) |
| | LIG1 | DNA ligase. (921 aa) |
| | SLX1 | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (269 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (1978 aa) |
| | FAN1 | Fanconi-associated nuclease 1; Nuclease required for the repair of DNA interstrand cross- links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Pro [...] (1026 aa) |
| | RFC2 | Replication factor C subunit 2. (353 aa) |
| | FANCG | FA complementation group G. (630 aa) |
| | FAAP24 | FA core complex associated protein 24. (215 aa) |
| | MSH3 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1122 aa) |
| | FANCL | FA complementation group L. (378 aa) |
| | FAAP100 | FA core complex associated protein 100. (825 aa) |
| | FANCD2 | FA complementation group D2. (1450 aa) |
| | RFC5 | Replication factor C subunit 5. (340 aa) |
| | OGG1 | 8-oxoguanine DNA glycosylase. (344 aa) |
| | RPA3 | Replication protein A3. (121 aa) |
| | ZRANB3 | Zinc finger RANBP2-type containing 3. (1019 aa) |
| | G1MDH9_AILME | Uncharacterized protein. (1605 aa) |
| | UNG | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (312 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3058 aa) |
| | UVSSA | UV stimulated scaffold protein A. (713 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (264 aa) |
| | G1MF02_AILME | Uncharacterized protein. (75 aa) |
| | POLE4 | DNA polymerase epsilon 4, accessory subunit. (96 aa) |
| | CHD1L | Chromodomain helicase DNA binding protein 1 like. (898 aa) |
| | POLD3 | DNA polymerase delta 3, accessory subunit. (463 aa) |
| | POLI | DNA polymerase iota. (754 aa) |
| | GINS3 | GINS complex subunit 3. (216 aa) |
| | MUS81 | MUS81 structure-specific endonuclease subunit. (552 aa) |
| | CENPX | Uncharacterized protein. (85 aa) |
| | NUTF2 | NTF2 domain-containing protein. (127 aa) |
| | POLD2 | Uncharacterized protein. (469 aa) |
| | POLA2 | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (596 aa) |
| | POLL | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (575 aa) |
| | NTHL1 | Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (307 aa) |
| | RAD50 | Zinc-hook domain-containing protein. (1312 aa) |
| | UBE2B | Ubiquitin conjugating enzyme E2 B; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | MLH1 | MutL homolog 1. (757 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1062 aa) |
| | XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (349 aa) |
| | GINS2 | GINS complex subunit 2. (185 aa) |
| | MLH3 | MutL homolog 3. (1454 aa) |
| | ORC6 | Origin recognition complex subunit 6. (265 aa) |
| | G1MKW1_AILME | NTF2 domain-containing protein. (126 aa) |
| | PANDA_012579 | BRCT domain-containing protein. (79 aa) |
| | RMI1 | RecQ mediated genome instability 1. (627 aa) |
| | FEN1 | Flap structure-specific endonuclease 1. (380 aa) |
