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ELAVL1 ELAVL1 TRIM71 TRIM71 AGO2 AGO2 RAN RAN HELZ HELZ PUM1 PUM1 AGO3 AGO3 AGO1 AGO1 AGO4 AGO4 NRDE2 NRDE2 DHX9 DHX9 MOV10L1 MOV10L1 CNOT1 CNOT1 WTIP WTIP GIGYF2 GIGYF2 CLP1 CLP1 TNRC6C TNRC6C TARBP2 TARBP2 XPO5 XPO5 LIMD1 LIMD1 CT55 CT55 TNRC6B TNRC6B RBM4 RBM4 EIF6 EIF6 MARF1 MARF1 ZAR1L ZAR1L TNRC6A TNRC6A G1LAL6_AILME G1LAL6_AILME MOV10 MOV10 G1L8I8_AILME G1L8I8_AILME ZFP36 ZFP36 AJUBA AJUBA EIF4ENIF1 EIF4ENIF1 DICER1 DICER1 DDX6 DDX6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ELAVL1ELAV-like protein; Belongs to the RRM elav family. (336 aa)
TRIM71Tripartite motif containing 71. (603 aa)
AGO2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (858 aa)
RANGTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (216 aa)
HELZHelicase with zinc finger. (1945 aa)
PUM1Pumilio RNA binding family member 1. (1226 aa)
AGO3Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (860 aa)
AGO1Argonaute RISC component 1; Belongs to the argonaute family. (857 aa)
AGO4Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (859 aa)
NRDE2NRDE-2, necessary for RNA interference, domain containing. (1158 aa)
DHX9DExH-box helicase 9. (1276 aa)
MOV10L1Mov10 like RISC complex RNA helicase 1. (1150 aa)
CNOT1CCR4-NOT transcription complex subunit 1. (2371 aa)
WTIPUncharacterized protein. (173 aa)
GIGYF2GRB10 interacting GYF protein 2. (1301 aa)
CLP1Polyribonucleotide 5'-hydroxyl-kinase Clp1; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; thi [...] (433 aa)
TNRC6CTrinucleotide repeat containing adaptor 6C. (1795 aa)
TARBP2RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...] (366 aa)
XPO5Exportin 5. (1205 aa)
LIMD1LIM domains containing 1. (672 aa)
CT55S1-like domain-containing protein. (238 aa)
TNRC6BTrinucleotide repeat containing adaptor 6B. (1847 aa)
RBM4RNA binding motif protein 4. (365 aa)
EIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (245 aa)
MARF1Meiosis regulator and mRNA stability factor 1. (1742 aa)
ZAR1LZygote arrest 1 like. (323 aa)
TNRC6ATrinucleotide repeat containing adaptor 6A. (1912 aa)
G1LAL6_AILMEGTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (209 aa)
MOV10Mov10 RISC complex RNA helicase. (1025 aa)
G1L8I8_AILMEzf-3CxxC domain-containing protein. (360 aa)
ZFP36ZFP36 ring finger protein. (325 aa)
AJUBAAjuba LIM protein. (546 aa)
EIF4ENIF1Eukaryotic translation initiation factor 4E nuclear import factor 1. (986 aa)
DICER1Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1922 aa)
DDX6DEAD-box helicase 6; Belongs to the DEAD box helicase family. (483 aa)
Your Current Organism:
Ailuropoda melanoleuca
NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda
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