STRINGSTRING
RUVBL2 RUVBL2 GINS2 GINS2 TREX1 TREX1 HELB HELB HFM1 HFM1 RFC4 RFC4 DDX1 DDX1 G1L3P7_AILME G1L3P7_AILME MCM5 MCM5 MCM4 MCM4 RTEL1 RTEL1 FBH1 FBH1 FANCM FANCM DSCC1 DSCC1 DHX9 DHX9 PIF1 PIF1 GINS4 GINS4 CHD3 CHD3 XRCC5 XRCC5 MCM9 MCM9 WRNIP1 WRNIP1 TM4SF19 TM4SF19 DDX11 DDX11 HELQ HELQ RECQL4 RECQL4 ERCC6L ERCC6L CHD7 CHD7 SMARCAD1 SMARCAD1 MCM6 MCM6 SUB1 SUB1 CHD8 CHD8 DDX3X DDX3X DHX32 DHX32 CHTF18 CHTF18 DERPC DERPC MRE11 MRE11 RPA1 RPA1 G3BP1 G3BP1 C17orf64 C17orf64 MCM3 MCM3 IGHMBP2 IGHMBP2 BRIP1 BRIP1 G1LQE2_AILME G1LQE2_AILME RFC3 RFC3 CHD6 CHD6 RECQL5 RECQL5 CHD5 CHD5 MCM8 MCM8 CHD2 CHD2 PURA PURA MCM7 MCM7 UPF1 UPF1 CDC45 CDC45 DHX36 DHX36 SLFNL1 SLFNL1 ERCC2 ERCC2 MCMDC2 MCMDC2 GTF2F2 GTF2F2 BLM BLM CHD4 CHD4 CHD1 CHD1 ASCC3 ASCC3 POLQ POLQ MCM2 MCM2 NBN NBN POT1 POT1 SSBP1 SSBP1 RUVBL1 RUVBL1 RFC2 RFC2 ANXA1 ANXA1 XRCC6 XRCC6 RECQL RECQL CHD9 CHD9 ERCC3 ERCC3 RAD51 RAD51 G1MF02_AILME G1MF02_AILME CHD3-2 CHD3-2 CHD1L CHD1L DQX1 DQX1 GINS3 GINS3 TWNK TWNK RAD50 RAD50 SUPV3L1 SUPV3L1 DNA2 DNA2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (467 aa)
GINS2GINS complex subunit 2. (185 aa)
TREX1Three prime repair exonuclease 1. (314 aa)
HELBDNA helicase B. (1058 aa)
HFM1Helicase for meiosis 1. (1439 aa)
RFC4Replication factor C subunit 4. (365 aa)
DDX1DEAD-box helicase 1. (740 aa)
G1L3P7_AILMENTF2 domain-containing protein. (428 aa)
MCM5DNA helicase; Belongs to the MCM family. (729 aa)
MCM4DNA helicase; Belongs to the MCM family. (863 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1305 aa)
FBH1F-box DNA helicase 1. (1048 aa)
FANCMFA complementation group M. (2048 aa)
DSCC1DNA replication and sister chromatid cohesion 1. (393 aa)
DHX9DExH-box helicase 9. (1276 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (643 aa)
GINS4GINS complex subunit 4. (223 aa)
CHD3Chromodomain helicase DNA binding protein 3. (1364 aa)
XRCC5X-ray repair cross complementing 5. (734 aa)
MCM9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1141 aa)
WRNIP1WRN helicase interacting protein 1. (601 aa)
TM4SF19Uncharacterized protein. (214 aa)
DDX11DEAD/H-box helicase 11. (906 aa)
HELQHelicase, POLQ like. (1004 aa)
RECQL4RecQ like helicase 4. (1203 aa)
ERCC6LERCC excision repair 6 like, spindle assembly checkpoint helicase. (1238 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2995 aa)
SMARCAD1Uncharacterized protein. (1028 aa)
MCM6DNA helicase; Belongs to the MCM family. (822 aa)
SUB1SUB1 regulator of transcription. (134 aa)
CHD8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2586 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (675 aa)
DHX32DEAH-box helicase 32 (putative). (752 aa)
CHTF18Chromosome transmission fidelity factor 18. (1114 aa)
DERPCDERPC proline and glycine rich nuclear protein. (529 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (712 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (619 aa)
G3BP1Uncharacterized protein. (477 aa)
C17orf64Chromosome 17 open reading frame 64. (234 aa)
MCM3DNA helicase; Belongs to the MCM family. (845 aa)
IGHMBP2Immunoglobulin mu DNA binding protein 2. (992 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1250 aa)
G1LQE2_AILMEDUF4208 domain-containing protein. (663 aa)
RFC3Replication factor C subunit 3. (356 aa)
CHD6Chromodomain helicase DNA binding protein 6. (2717 aa)
RECQL5ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (985 aa)
CHD5Chromodomain helicase DNA binding protein 5. (1922 aa)
MCM8MCM domain-containing protein; Belongs to the MCM family. (835 aa)
CHD2Uncharacterized protein. (1152 aa)
PURAPurine rich element binding protein A. (303 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
UPF1UPF1 RNA helicase and ATPase. (1125 aa)
CDC45Cell division cycle 45. (602 aa)
DHX36DEAH-box helicase 36. (1009 aa)
SLFNL1Schlafen like 1. (393 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (762 aa)
MCMDC2Minichromosome maintenance domain containing 2. (681 aa)
GTF2F2General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (249 aa)
BLMBLM RecQ like helicase. (1412 aa)
CHD4Uncharacterized protein. (1929 aa)
CHD1Chromodomain helicase DNA binding protein 1. (1780 aa)
ASCC3Activating signal cointegrator 1 complex subunit 3. (2202 aa)
POLQDNA polymerase theta. (2630 aa)
MCM2DNA helicase; Belongs to the MCM family. (903 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (769 aa)
POT1Protection of telomeres 1. (635 aa)
SSBP1Single stranded DNA binding protein 1. (148 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
RFC2Replication factor C subunit 2. (353 aa)
ANXA1Annexin. (345 aa)
XRCC6X-ray repair cross complementing 6. (607 aa)
RECQLATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (646 aa)
CHD9Chromodomain helicase DNA binding protein 9. (2903 aa)
ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit. (778 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (264 aa)
G1MF02_AILMEUncharacterized protein. (75 aa)
CHD3-2Uncharacterized protein. (561 aa)
CHD1LChromodomain helicase DNA binding protein 1 like. (898 aa)
DQX1DEAQ-box RNA dependent ATPase 1. (718 aa)
GINS3GINS complex subunit 3. (216 aa)
TWNKTwinkle mtDNA helicase. (684 aa)
RAD50Zinc-hook domain-containing protein. (1312 aa)
SUPV3L1Suv3 like RNA helicase. (790 aa)
DNA2DNA replication helicase/nuclease 2. (1062 aa)
Your Current Organism:
Ailuropoda melanoleuca
NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda
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