(39 nodes) Negative regulation of MAP kinase activity network (Ailuropoda melanoleuca)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

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Your Input:
	GBA	Glucosylceramidase. (536 aa)
	IRAK3	Interleukin 1 receptor associated kinase 3. (566 aa)
	HMGCR	3-hydroxy-3-methylglutaryl coenzyme A reductase. (888 aa)
	LAX1	Lymphocyte transmembrane adaptor 1. (410 aa)
	DAB2IP	DAB2 interacting protein. (990 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (244 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	G1L3H5_AILME	Ig-like domain-containing protein. (314 aa)
	LYN	Tyrosine-protein kinase. (512 aa)
	SPRY2	Sprouty RTK signaling antagonist 2. (343 aa)
	SFRP1	Secreted frizzled related protein 1. (314 aa)
	CDK5RAP3	CDK5 regulatory subunit associated protein 3. (508 aa)
	PTPRJ	Protein tyrosine phosphatase receptor type J. (1210 aa)
	PAQR3	Progestin and adipoQ receptor family member 3. (311 aa)
	NF1	Neurofibromin 1. (2820 aa)
	TMEM130	Transmembrane protein 130. (407 aa)
	DUSP10	Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
	INPP5K	Inositol polyphosphate-5-phosphatase K. (468 aa)
	SORL1	Sortilin related receptor 1. (2178 aa)
	DEFB114	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (67 aa)
	AGT	Angiotensinogen; Belongs to the serpin family. (484 aa)
	NUP62CL	Nsp1_C domain-containing protein. (500 aa)
	BMP2	Bone morphogenetic protein 2. (395 aa)
	DUSP16	Dual specificity phosphatase 16. (663 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (154 aa)
	APOE	Apolipoprotein E. (311 aa)
	CBLC	Cbl proto-oncogene C. (496 aa)
	BMP7	Bone morphogenetic protein 7. (427 aa)
	PTPN1	Tyrosine-protein phosphatase non-receptor type. (425 aa)
	SH2B3	SH2B adaptor protein 3. (577 aa)
	PTPN6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (613 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	SMPD1	Sphingomyelin phosphodiesterase 1. (641 aa)
	RGS14	Regulator of G protein signaling 14. (568 aa)
	SFRP2	Secreted frizzled related protein 2. (301 aa)
	SPRY3	Sprouty RTK signaling antagonist 3. (288 aa)
	NUP62	Nucleoporin 62. (521 aa)
	SPRY4	Sprouty RTK signaling antagonist 4. (319 aa)
	SPRY1	Sprouty RTK signaling antagonist 1. (319 aa)

Your Current Organism:

Ailuropoda melanoleuca

NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIPOQ	APOE	ENSAMEP00000000973	ENSAMEP00000013408	Adiponectin, C1Q and collagen domain containing.	Apolipoprotein E.	0.452
ADIPOQ	CAV1	ENSAMEP00000000973	ENSAMEP00000001406	Adiponectin, C1Q and collagen domain containing.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.435
ADIPOQ	PAQR3	ENSAMEP00000000973	ENSAMEP00000005629	Adiponectin, C1Q and collagen domain containing.	Progestin and adipoQ receptor family member 3.	0.524
AGT	APOE	ENSAMEP00000010215	ENSAMEP00000013408	Angiotensinogen; Belongs to the serpin family.	Apolipoprotein E.	0.461
APOE	ADIPOQ	ENSAMEP00000013408	ENSAMEP00000000973	Apolipoprotein E.	Adiponectin, C1Q and collagen domain containing.	0.452
APOE	AGT	ENSAMEP00000013408	ENSAMEP00000010215	Apolipoprotein E.	Angiotensinogen; Belongs to the serpin family.	0.461
APOE	CAV1	ENSAMEP00000013408	ENSAMEP00000001406	Apolipoprotein E.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.605
APOE	HMGCR	ENSAMEP00000013408	ENSAMEP00000000725	Apolipoprotein E.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.526
APOE	SORL1	ENSAMEP00000013408	ENSAMEP00000008783	Apolipoprotein E.	Sortilin related receptor 1.	0.633
BMP2	BMP4	ENSAMEP00000011076	ENSAMEP00000016145	Bone morphogenetic protein 2.	Bone morphogenetic protein 4.	0.928
BMP2	BMP7	ENSAMEP00000011076	ENSAMEP00000013537	Bone morphogenetic protein 2.	Bone morphogenetic protein 7.	0.642
BMP4	BMP2	ENSAMEP00000016145	ENSAMEP00000011076	Bone morphogenetic protein 4.	Bone morphogenetic protein 2.	0.928
BMP4	BMP7	ENSAMEP00000016145	ENSAMEP00000013537	Bone morphogenetic protein 4.	Bone morphogenetic protein 7.	0.786
BMP4	SPRY2	ENSAMEP00000016145	ENSAMEP00000002645	Bone morphogenetic protein 4.	Sprouty RTK signaling antagonist 2.	0.438
BMP7	BMP2	ENSAMEP00000013537	ENSAMEP00000011076	Bone morphogenetic protein 7.	Bone morphogenetic protein 2.	0.642
BMP7	BMP4	ENSAMEP00000013537	ENSAMEP00000016145	Bone morphogenetic protein 7.	Bone morphogenetic protein 4.	0.786
CAV1	ADIPOQ	ENSAMEP00000001406	ENSAMEP00000000973	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Adiponectin, C1Q and collagen domain containing.	0.435
CAV1	APOE	ENSAMEP00000001406	ENSAMEP00000013408	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Apolipoprotein E.	0.605
CAV1	CAV3	ENSAMEP00000001406	ENSAMEP00000013002	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.954
CAV3	CAV1	ENSAMEP00000013002	ENSAMEP00000001406	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.954