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TRMT10C TRMT10C TOB1 TOB1 RPUSD3 RPUSD3 EIF5A EIF5A LARP1 LARP1 FXR2 FXR2 CSDE1 CSDE1 EIF4G1 EIF4G1 THBS1 THBS1 RPUSD4 RPUSD4 UPF3B UPF3B PRKDC PRKDC PABPC1 PABPC1 G1L132_AILME G1L132_AILME FASTKD3 FASTKD3 RPS6KB2 RPS6KB2 LARP4 LARP4 UHMK1 UHMK1 YTHDF1 YTHDF1 G1MI64_AILME G1MI64_AILME PRR16 PRR16 YTHDF3 YTHDF3 UCN UCN G1L496_AILME G1L496_AILME WRN WRN LARP4B LARP4B DHX9 DHX9 EEF2 EEF2 PLXNB2 PLXNB2 LARP1B LARP1B FASTKD2 FASTKD2 PINK1 PINK1 PYM1 PYM1 PIWIL2 PIWIL2 PAIP1 PAIP1 G1LBA3_AILME G1LBA3_AILME UPF3A UPF3A RPS9 RPS9 EIF5A2 EIF5A2 IGF2BP1 IGF2BP1 KRT17 KRT17 G1LH80_AILME G1LH80_AILME C1QBP C1QBP PARP6 PARP6 ZCCHC4 ZCCHC4 JMJD4 JMJD4 PKM PKM METTL3 METTL3 POLR2G POLR2G NCK1 NCK1 CTIF CTIF DDX3X DDX3X COA3 COA3 MRPS27 MRPS27 G1LLY7_AILME G1LLY7_AILME KHDRBS1 KHDRBS1 NAT10 NAT10 USP16 USP16 BARHL2 BARHL2 ELAVL1 ELAVL1 LARP6 LARP6 DAZL DAZL HNRNPU HNRNPU MIF4GD MIF4GD TNF TNF POLDIP3 POLDIP3 MTOR MTOR EIF3D EIF3D EIF6 EIF6 ERBB2 ERBB2 DNAJC3 DNAJC3 METTL5 METTL5 G1LVG3_AILME G1LVG3_AILME TENT5B TENT5B RBM4 RBM4 MPV17L2 MPV17L2 RMND1 RMND1 SOX4 SOX4 RPS6KB1 RPS6KB1 YTHDF2 YTHDF2 METTL14 METTL14 DHX36 DHX36 HABP4 HABP4 FXR1 FXR1 TARBP2 TARBP2 RBM3 RBM3 PCIF1 PCIF1 EIF2S3 EIF2S3 EIF3E EIF3E BCL3 BCL3 CDK5RAP1 CDK5RAP1 NCK2 NCK2 ABCF1 ABCF1 NIBAN1 NIBAN1 NGRN NGRN BOLL BOLL DHX29 DHX29 IMPACT IMPACT FMR1 FMR1 RCC1L RCC1L EIF4A3 EIF4A3 CNBP CNBP SAMD4A SAMD4A SYNCRIP SYNCRIP GUF1 GUF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TRMT10CtRNA methyltransferase 10C, mitochondrial RNase P subunit. (414 aa)
TOB1Transducer of ERBB2, 1. (344 aa)
RPUSD3RNA pseudouridine synthase D3. (352 aa)
EIF5AEukaryotic translation initiation factor 5A. (154 aa)
LARP1La ribonucleoprotein domain family member 1. (957 aa)
FXR2FMR1 autosomal homolog 2. (660 aa)
CSDE1Cold shock domain containing E1. (813 aa)
EIF4G1Eukaryotic translation initiation factor 4 gamma 1. (1630 aa)
THBS1Thrombospondin 1. (1182 aa)
RPUSD4PseudoU_synth_2 domain-containing protein. (377 aa)
UPF3BUPF3B regulator of nonsense mediated mRNA decay. (483 aa)
PRKDCUncharacterized protein; Belongs to the PI3/PI4-kinase family. (2279 aa)
PABPC1Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (636 aa)
G1L132_AILMEUncharacterized protein. (356 aa)
FASTKD3FAST kinase domains 3. (662 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
LARP4La ribonucleoprotein domain family member 4. (720 aa)
UHMK1U2AF homology motif kinase 1. (419 aa)
YTHDF1YTH N6-methyladenosine RNA binding protein 1. (562 aa)
G1MI64_AILMEUncharacterized protein. (183 aa)
PRR16Proline rich 16. (304 aa)
YTHDF3YTH N6-methyladenosine RNA binding protein 3. (585 aa)
UCNUrocortin. (123 aa)
G1L496_AILMEUncharacterized protein. (1131 aa)
WRN3'-5' exonuclease domain-containing protein. (268 aa)
LARP4BLa ribonucleoprotein domain family member 4B. (734 aa)
DHX9DExH-box helicase 9. (1276 aa)
EEF2Tr-type G domain-containing protein. (858 aa)
PLXNB2Plexin B2. (2029 aa)
LARP1BLa ribonucleoprotein domain family member 1B. (549 aa)
FASTKD2FAST kinase domains 2. (691 aa)
PINK1PTEN induced kinase 1. (453 aa)
PYM1PYM homolog 1, exon junction complex associated factor. (202 aa)
PIWIL2Piwi like RNA-mediated gene silencing 2; Belongs to the argonaute family. (970 aa)
PAIP1Poly(A) binding protein interacting protein 1. (407 aa)
G1LBA3_AILMEIF rod domain-containing protein. (137 aa)
UPF3AUPF3A regulator of nonsense mediated mRNA decay. (455 aa)
RPS9Ribosomal protein S9; Belongs to the universal ribosomal protein uS4 family. (194 aa)
EIF5A2Eukaryotic translation initiation factor 5A. (153 aa)
IGF2BP1Insulin like growth factor 2 mRNA binding protein 1. (597 aa)
KRT17Keratin 17; Belongs to the intermediate filament family. (430 aa)
G1LH80_AILMEPseudoU_synth_2 domain-containing protein. (230 aa)
C1QBPUncharacterized protein. (206 aa)
PARP6Poly [ADP-ribose] polymerase. (743 aa)
ZCCHC4Uncharacterized protein. (273 aa)
JMJD4Jumonji domain containing 4. (391 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (575 aa)
METTL3Methyltransferase like 3; Belongs to the MT-A70-like family. (580 aa)
POLR2GRNA polymerase II subunit G. (172 aa)
NCK1Cytoplasmic protein. (378 aa)
CTIFCap binding complex dependent translation initiation factor. (634 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (675 aa)
COA3Cytochrome c oxidase assembly factor 3. (105 aa)
MRPS27Mitochondrial ribosomal protein S27. (328 aa)
G1LLY7_AILMEUncharacterized protein. (119 aa)
KHDRBS1KH RNA binding domain containing, signal transduction associated 1. (418 aa)
NAT10RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1026 aa)
USP16Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. (824 aa)
BARHL2BarH like homeobox 2. (377 aa)
ELAVL1ELAV-like protein; Belongs to the RRM elav family. (336 aa)
LARP6La ribonucleoprotein domain family member 6. (427 aa)
DAZLDeleted in azoospermia like. (295 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (821 aa)
MIF4GDMIF4G domain containing. (266 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
POLDIP3DNA polymerase delta interacting protein 3. (429 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2544 aa)
EIF3DEukaryotic translation initiation factor 3 subunit D; mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl- tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required [...] (548 aa)
EIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (245 aa)
ERBB2Receptor protein-tyrosine kinase. (1263 aa)
DNAJC3DnaJ heat shock protein family (Hsp40) member C3. (508 aa)
METTL5Methyltransferase like 5. (213 aa)
G1LVG3_AILMEUncharacterized protein. (311 aa)
TENT5BTerminal nucleotidyltransferase 5B. (431 aa)
RBM4RNA binding motif protein 4. (365 aa)
MPV17L2MPV17 mitochondrial inner membrane protein like 2; Belongs to the peroxisomal membrane protein PXMP2/4 family. (202 aa)
RMND1Required for meiotic nuclear division 1 homolog. (449 aa)
SOX4SRY-box transcription factor 4. (264 aa)
RPS6KB1Ribosomal protein S6 kinase B1. (525 aa)
YTHDF2YTH N6-methyladenosine RNA binding protein 2. (581 aa)
METTL14Methyltransferase like 14; Belongs to the MT-A70-like family. (456 aa)
DHX36DEAH-box helicase 36. (1009 aa)
HABP4Hyaluronan binding protein 4. (389 aa)
FXR1FMR1 autosomal homolog 1. (663 aa)
TARBP2RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...] (366 aa)
RBM3RNA binding motif protein 3. (161 aa)
PCIF1PDX1 C-terminal inhibiting factor 1. (703 aa)
EIF2S3Tr-type G domain-containing protein. (472 aa)
EIF3EEukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (445 aa)
BCL3BCL3 transcription coactivator. (440 aa)
CDK5RAP1CDK5 regulatory subunit associated protein 1. (583 aa)
NCK2NCK adaptor protein 2. (380 aa)
ABCF1ATP binding cassette subfamily F member 1. (845 aa)
NIBAN1Niban apoptosis regulator 1. (936 aa)
NGRNNeugrin, neurite outgrowth associated. (222 aa)
BOLLBoule homolog, RNA binding protein. (295 aa)
DHX29ATP-dependent RNA helicase DHX29; ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity; Belongs to the DEAD box helicase family. DEAH subfamily. (1357 aa)
IMPACTImpact RWD domain protein. (309 aa)
FMR1Fragile X mental retardation 1. (632 aa)
RCC1LRCC1 like. (405 aa)
EIF4A3Eukaryotic translation initiation factor 4A3; Belongs to the DEAD box helicase family. (405 aa)
CNBPCCHC-type zinc finger nucleic acid binding protein. (179 aa)
SAMD4ASterile alpha motif domain containing 4A. (717 aa)
SYNCRIPSynaptotagmin binding cytoplasmic RNA interacting protein. (634 aa)
GUF1Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. (669 aa)
Your Current Organism:
Ailuropoda melanoleuca
NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda
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