(63 nodes) Regulation of fibroblast proliferation network (Ailuropoda melanoleuca)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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gene co-occurrence

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protein homology

Your Input:
	JUN	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (301 aa)
	FBRS	Uncharacterized protein. (182 aa)
	EMD	Emerin. (260 aa)
	MED31	Mediator of RNA polymerase II transcription subunit 31; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (131 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (368 aa)
	AQP1	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
	B4GALT7	Beta-1,4-galactosyltransferase 7. (327 aa)
	INCA1	Inhibitor of CDK, cyclin A1 interacting protein 1. (235 aa)
	BMI1	RING-type domain-containing protein. (326 aa)
	TP53INP1	Tumor protein p53 inducible nuclear protein 1. (239 aa)
	MORC3	MORC family CW-type zinc finger 3. (990 aa)
	NF1	Neurofibromin 1. (2820 aa)
	PLA2G1B	Phospholipase A(2). (148 aa)
	CD74	CD74 molecule. (295 aa)
	GAS6	Growth arrest specific 6. (674 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
	FN1	Fibronectin 1. (2476 aa)
	PDGFA	Platelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (210 aa)
	SFRP1	Secreted frizzled related protein 1. (314 aa)
	CTC1	CST telomere replication complex component 1. (1214 aa)
	DHX9	DExH-box helicase 9. (1276 aa)
	DDR2	Discoidin domain receptor tyrosine kinase 2. (862 aa)
	G1L3H5_AILME	Ig-like domain-containing protein. (314 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa)
	FNDC3B	Fibronectin type III domain containing 3B. (1207 aa)
	C1QL4	Complement C1q like 4. (238 aa)
	DAB2IP	DAB2 interacting protein. (990 aa)
	NDUFS4	NADH:ubiquinone oxidoreductase subunit S4. (143 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa)
	LIF	LIF interleukin 6 family cytokine. (202 aa)
	CDKN1A	Cyclin dependent kinase inhibitor 1A. (167 aa)
	LIG4	DNA ligase. (916 aa)
	TRIM32	Tripartite motif containing 32. (655 aa)
	PEX2	Peroxisomal biogenesis factor 2. (305 aa)
	PDGFRA	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
	CDK6	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
	LZTS2	Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (649 aa)
	CD248	CD248 molecule. (697 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
	ABL1	Tyrosine-protein kinase. (1150 aa)
	BRK1	Uncharacterized protein. (90 aa)
	CDC73	Cell division cycle 73. (531 aa)
	FBXO4	F-box protein 4. (387 aa)
	FOSL2	FOS like 2, AP-1 transcription factor subunit. (326 aa)
	NUPR1	Nuclear protein 1, transcriptional regulator. (82 aa)
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (790 aa)
	MYC	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (452 aa)
	EREG	Epiregulin. (148 aa)
	PDGFC	Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
	MED25	Mediator complex subunit 25. (746 aa)
	PAWR	Pro-apoptotic WT1 regulator. (217 aa)
	ZMIZ1	Zinc finger MIZ-type containing 1. (1063 aa)
	DACH1	Dachshund family transcription factor 1. (427 aa)
	IFI30	IFI30 lysosomal thiol reductase. (249 aa)
	ESR1	Estrogen receptor 1. (449 aa)
	PDGFB	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (239 aa)
	SPHK1	Sphingosine kinase 1. (473 aa)
	WAPL	Uncharacterized protein. (554 aa)
	G1LTK3_AILME	WAPL domain-containing protein. (402 aa)
	PML	Promyelocytic leukemia. (880 aa)
	E2F1	E2F transcription factor 1. (355 aa)
	PANDA_015976	Uncharacterized protein. (301 aa)

Your Current Organism:

Ailuropoda melanoleuca

NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	BRK1	ENSAMEP00000017165	ENSAMEP00000016935	Tyrosine-protein kinase.	Uncharacterized protein.	0.454
ABL1	CDKN1A	ENSAMEP00000017165	ENSAMEP00000000279	Tyrosine-protein kinase.	Cyclin dependent kinase inhibitor 1A.	0.519
ABL1	TP53	ENSAMEP00000017165	ENSAMEP00000017825	Tyrosine-protein kinase.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.464
BMI1	E2F1	ENSAMEP00000006564	ENSAMEP00000009461	RING-type domain-containing protein.	E2F transcription factor 1.	0.453
BMI1	MYC	ENSAMEP00000006564	ENSAMEP00000015501	RING-type domain-containing protein.	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.474
BMI1	TP53	ENSAMEP00000006564	ENSAMEP00000017825	RING-type domain-containing protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.660
BRK1	ABL1	ENSAMEP00000016935	ENSAMEP00000017165	Uncharacterized protein.	Tyrosine-protein kinase.	0.454
CAV1	ESR1	ENSAMEP00000001406	ENSAMEP00000011636	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Estrogen receptor 1.	0.873
CAV1	ITGB3	ENSAMEP00000001406	ENSAMEP00000015523	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Integrin beta; Belongs to the integrin beta chain family.	0.932
CDK6	CDKN1A	ENSAMEP00000018812	ENSAMEP00000000279	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	Cyclin dependent kinase inhibitor 1A.	0.997
CDK6	E2F1	ENSAMEP00000018812	ENSAMEP00000009461	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	E2F transcription factor 1.	0.733
CDK6	ESR1	ENSAMEP00000018812	ENSAMEP00000011636	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	Estrogen receptor 1.	0.503
CDK6	FBRS	ENSAMEP00000018812	ENSAMEP00000008209	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.403
CDK6	JUN	ENSAMEP00000018812	ENSAMEP00000000287	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	0.414
CDK6	MYC	ENSAMEP00000018812	ENSAMEP00000015501	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.423
CDK6	TP53	ENSAMEP00000018812	ENSAMEP00000017825	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.766
CDKN1A	ABL1	ENSAMEP00000000279	ENSAMEP00000017165	Cyclin dependent kinase inhibitor 1A.	Tyrosine-protein kinase.	0.519
CDKN1A	CDK6	ENSAMEP00000000279	ENSAMEP00000018812	Cyclin dependent kinase inhibitor 1A.	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	0.997
CDKN1A	E2F1	ENSAMEP00000000279	ENSAMEP00000009461	Cyclin dependent kinase inhibitor 1A.	E2F transcription factor 1.	0.631
CDKN1A	ESR1	ENSAMEP00000000279	ENSAMEP00000011636	Cyclin dependent kinase inhibitor 1A.	Estrogen receptor 1.	0.540