(41 nodes) Dendrite morphogenesis network (Ailuropoda melanoleuca)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EPHB1	EPH receptor B1. (945 aa)
	ABITRAM	Actin binding transcription modulator. (198 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (798 aa)
	MAP6	Microtubule associated protein 6. (782 aa)
	PTN	Pleiotrophin. (168 aa)
	ELAVL4	ELAV-like protein; Belongs to the RRM elav family. (385 aa)
	DLG4	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (761 aa)
	NFATC4	Nuclear factor of activated T cells 4. (954 aa)
	KLF7	Kruppel like factor 7. (302 aa)
	MAP2	Microtubule-associated protein. (1862 aa)
	EPHB2	EPH receptor B2. (968 aa)
	PREX2	Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2. (1605 aa)
	CDC42	Cell division cycle 42. (231 aa)
	DVL1	Dishevelled segment polarity protein 1. (700 aa)
	CDK5	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
	SHANK1	SH3 and multiple ankyrin repeat domains 1. (1687 aa)
	HDAC6	Histone deacetylase 6. (1174 aa)
	NKPD1	Uncharacterized protein. (266 aa)
	VLDLR	Very low density lipoprotein receptor. (873 aa)
	PAK3	P21 (RAC1) activated kinase 3. (580 aa)
	DCX	Doublecortin. (426 aa)
	DOCK10	Dedicator of cytokinesis 10; Belongs to the DOCK family. (2178 aa)
	EPHB3	EPH receptor B3. (999 aa)
	TMEM106B	Transmembrane protein 106B. (319 aa)
	LRP8	LDL receptor related protein 8. (964 aa)
	SLITRK5	SLIT and NTRK like family member 5. (860 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (521 aa)
	RBFOX2	RNA binding fox-1 homolog 2. (297 aa)
	G1LH72_AILME	Uncharacterized protein. (186 aa)
	DCLK1	Doublecortin like kinase 1. (740 aa)
	WASL	WASP like actin nucleation promoting factor. (499 aa)
	BTBD3	BTB domain containing 3. (544 aa)
	RERE	Arginine-glutamic acid dipeptide repeats. (1505 aa)
	ZNF365	Zinc finger protein 365. (407 aa)
	MEF2A	Myocyte enhancer factor 2A. (530 aa)
	SHANK3	SH3 and multiple ankyrin repeat domains 3. (1644 aa)
	MAPK8IP2	Mitogen-activated protein kinase 8 interacting protein 2. (773 aa)
	PHACTR1	Phosphatase and actin regulator. (492 aa)
	G1L7K3_AILME	Uncharacterized protein. (74 aa)
	ABI1	Abl interactor 1. (509 aa)
	PTEN	Phosphatase and tensin homolog. (403 aa)

Your Current Organism:

Ailuropoda melanoleuca

NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABI1	CDC42	ENSAMEP00000002027	ENSAMEP00000015397	Abl interactor 1.	Cell division cycle 42.	0.647
ABI1	G1LH72_AILME	ENSAMEP00000002027	ENSAMEP00000006266	Abl interactor 1.	Uncharacterized protein.	0.647
ABI1	PAK3	ENSAMEP00000002027	ENSAMEP00000012732	Abl interactor 1.	P21 (RAC1) activated kinase 3.	0.476
ABI1	SHANK1	ENSAMEP00000002027	ENSAMEP00000013610	Abl interactor 1.	SH3 and multiple ankyrin repeat domains 1.	0.481
ABI1	SHANK3	ENSAMEP00000002027	ENSAMEP00000003318	Abl interactor 1.	SH3 and multiple ankyrin repeat domains 3.	0.433
ABI1	WASL	ENSAMEP00000002027	ENSAMEP00000004800	Abl interactor 1.	WASP like actin nucleation promoting factor.	0.799
CDC42	ABI1	ENSAMEP00000015397	ENSAMEP00000002027	Cell division cycle 42.	Abl interactor 1.	0.647
CDC42	DOCK10	ENSAMEP00000015397	ENSAMEP00000012222	Cell division cycle 42.	Dedicator of cytokinesis 10; Belongs to the DOCK family.	0.837
CDC42	ITGB1	ENSAMEP00000015397	ENSAMEP00000018348	Cell division cycle 42.	Integrin beta; Belongs to the integrin beta chain family.	0.533
CDC42	PAK3	ENSAMEP00000015397	ENSAMEP00000012732	Cell division cycle 42.	P21 (RAC1) activated kinase 3.	0.909
CDC42	PREX2	ENSAMEP00000015397	ENSAMEP00000015604	Cell division cycle 42.	Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2.	0.618
CDC42	PTEN	ENSAMEP00000015397	ENSAMEP00000000745	Cell division cycle 42.	Phosphatase and tensin homolog.	0.438
CDC42	SHANK1	ENSAMEP00000015397	ENSAMEP00000013610	Cell division cycle 42.	SH3 and multiple ankyrin repeat domains 1.	0.416
CDC42	SHANK3	ENSAMEP00000015397	ENSAMEP00000003318	Cell division cycle 42.	SH3 and multiple ankyrin repeat domains 3.	0.441
CDC42	WASL	ENSAMEP00000015397	ENSAMEP00000004800	Cell division cycle 42.	WASP like actin nucleation promoting factor.	0.948
CDK5	DLG4	ENSAMEP00000014536	ENSAMEP00000017365	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily.	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	0.926
CDK5	MAP2	ENSAMEP00000014536	ENSAMEP00000015804	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily.	Microtubule-associated protein.	0.623
DCLK1	DCX	ENSAMEP00000004902	ENSAMEP00000012656	Doublecortin like kinase 1.	Doublecortin.	0.615
DCX	DCLK1	ENSAMEP00000012656	ENSAMEP00000004902	Doublecortin.	Doublecortin like kinase 1.	0.615
DCX	MAP2	ENSAMEP00000012656	ENSAMEP00000015804	Doublecortin.	Microtubule-associated protein.	0.619