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| | NEK7 | NIMA related kinase 7; Belongs to the protein kinase superfamily. (302 aa) |
| | CEBPG | CCAAT enhancer binding protein gamma. (147 aa) |
| | EXOSC6 | Uncharacterized protein. (91 aa) |
| | MORF4L2 | MRG domain-containing protein. (288 aa) |
| | MECP2 | Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (483 aa) |
| | DBF4B | DBF4-type domain-containing protein. (439 aa) |
| | GINS2 | GINS complex subunit 2. (185 aa) |
| | FGFR4 | Fibroblast growth factor receptor. (809 aa) |
| | SIRT1 | Sirtuin 1. (607 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1062 aa) |
| | E2F8 | E2F transcription factor 8. (863 aa) |
| | RAD50 | Zinc-hook domain-containing protein. (1312 aa) |
| | SLF2 | SMC5-SMC6 complex localization factor 2. (1160 aa) |
| | FGF2 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (96 aa) |
| | ACD | ACD shelterin complex subunit and telomerase recruitment factor. (482 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa) |
| | MRGBP | MRG domain binding protein. (155 aa) |
| | FAM168A | Family with sequence similarity 168 member A. (244 aa) |
| | GINS3 | GINS complex subunit 3. (216 aa) |
| | RPS3 | KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (248 aa) |
| | G1MF02_AILME | Uncharacterized protein. (75 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (264 aa) |
| | WRAP53 | WD repeat containing antisense to TP53. (537 aa) |
| | INO80 | INO80 complex ATPase subunit. (1561 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3058 aa) |
| | TNFSF13 | TNF superfamily member 13; Belongs to the tumor necrosis factor family. (251 aa) |
| | OTUD4 | OTU deubiquitinase 4. (1083 aa) |
| | HGF | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa) |
| | BRD8 | Bromo domain-containing protein. (951 aa) |
| | MAP3K4 | Mitogen-activated protein kinase kinase kinase 4. (1594 aa) |
| | EYA4 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (645 aa) |
| | NVL | Nuclear VCP like. (854 aa) |
| | UCHL5 | Ubiquitin carboxyl-terminal hydrolase. (329 aa) |
| | PRKCQ | Uncharacterized protein. (454 aa) |
| | FBXO4 | F-box protein 4. (387 aa) |
| | G1MBJ5_AILME | Non-specific serine/threonine protein kinase. (255 aa) |
| | ENDOG | Endonuclease G. (219 aa) |
| | TIGAR | TP53 induced glycolysis regulatory phosphatase. (269 aa) |
| | RAD51AP1 | RAD51 associated protein 1. (356 aa) |
| | CCT7 | T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. (555 aa) |
| | BAZ1A | Bromodomain adjacent to zinc finger domain 1A. (1536 aa) |
| | STOML2 | Stomatin like 2. (356 aa) |
| | TCP1 | T-complex 1. (557 aa) |
| | RFC2 | Replication factor C subunit 2. (353 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (483 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (1978 aa) |
| | SLX1 | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (269 aa) |
| | MAPK3 | Mitogen-activated protein kinase. (351 aa) |
| | CIZ1 | CDKN1A interacting zinc finger protein 1. (830 aa) |
| | HMCES | Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (354 aa) |
| | RUVBL1 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa) |
| | SSBP1 | Single stranded DNA binding protein 1. (148 aa) |
| | INO80E | INO80 complex subunit E. (248 aa) |
| | POT1 | Protection of telomeres 1. (635 aa) |
| | ZCWPW1 | Zinc finger CW-type and PWWP domain containing 1. (633 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (769 aa) |
| | EGF | Epidermal growth factor. (864 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (452 aa) |
| | BCL7A | BAF chromatin remodeling complex subunit BCL7A. (204 aa) |
| | CCT3 | T-complex protein 1 subunit gamma. (577 aa) |
| | RUVBL2 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (467 aa) |
| | PARP1 | Poly [ADP-ribose] polymerase. (981 aa) |
| | DTX3L | Deltex E3 ubiquitin ligase 3L. (733 aa) |
| | PARP9 | Poly(ADP-ribose) polymerase family member 9. (861 aa) |
| | PARM1 | Prostate androgen-regulated mucin-like protein 1. (301 aa) |
| | TNKS2 | Poly [ADP-ribose] polymerase. (1218 aa) |
| | EREG | Epiregulin. (148 aa) |
| | NSD2 | Nuclear receptor binding SET domain protein 2. (1370 aa) |
| | DMAP1 | DNA methyltransferase 1 associated protein 1. (468 aa) |
| | G1M5N4_AILME | Uncharacterized protein. (282 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (903 aa) |
| | EP400 | Uncharacterized protein. (1872 aa) |
| | PNKP | Polynucleotide kinase 3'-phosphatase. (521 aa) |
| | MAPKAPK5 | MAPK activated protein kinase 5. (473 aa) |
| | MFSD11 | Major facilitator superfamily domain containing 11. (454 aa) |
| | ARID2 | AT-rich interaction domain 2. (1836 aa) |
| | EYA2 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (440 aa) |
| | NRM | Nurim. (262 aa) |
| | ZNF112 | Uncharacterized protein. (905 aa) |
| | SPIRE1 | Spire type actin nucleation factor 1. (499 aa) |
| | PTPRC | Protein tyrosine phosphatase receptor type C. (1260 aa) |
| | WAS | WASP actin nucleation promoting factor. (469 aa) |
| | ERCC2 | ERCC excision repair 2, TFIIH core complex helicase subunit. (762 aa) |
| | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (298 aa) |
| | KAT7 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (611 aa) |
| | BRCC3 | BRCA1/BRCA2-containing complex subunit 3. (291 aa) |
| | CCT2 | Chaperonin containing TCP1 subunit 2. (534 aa) |
| | YEATS4 | YEATS domain containing 4. (227 aa) |
| | DHX36 | DEAH-box helicase 36. (1009 aa) |
| | TMEM161A | Transmembrane protein 161A. (481 aa) |
| | TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (355 aa) |
| | G1LYU2_AILME | Uncharacterized protein. (199 aa) |
| | PARN | Poly(A)-specific ribonuclease. (639 aa) |
| | EYA3 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (573 aa) |
| | G1LWH9_AILME | PHD-type domain-containing protein. (387 aa) |
| | PDGFB | Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (239 aa) |
| | USP7 | Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1112 aa) |
| | EYA1 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (425 aa) |
| | SLX4 | SLX4 structure-specific endonuclease subunit. (1574 aa) |
| | PPARGC1A | PPARG coactivator 1 alpha. (796 aa) |
| | BABAM1 | Uncharacterized protein. (364 aa) |
| | ERCC6 | ERCC excision repair 6, chromatin remodeling factor. (1481 aa) |
| | EPC1 | Enhancer of polycomb homolog. (842 aa) |
| | SHLD1 | Shieldin complex subunit 1. (206 aa) |
| | SMCHD1 | Structural maintenance of chromosomes flexible hinge domain containing 1. (1988 aa) |
| | SHLD2 | Shieldin complex subunit 2. (803 aa) |
| | MAD2L2 | Mitotic arrest deficient 2 like 2. (211 aa) |
| | BCAR3 | BCAR3 adaptor protein, NSP family member. (825 aa) |
| | SMARCA5 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1052 aa) |
| | G1LSP1_AILME | Uncharacterized protein. (271 aa) |
| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | PARP3 | Poly [ADP-ribose] polymerase. (531 aa) |
| | PML | Promyelocytic leukemia. (880 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | MAPK1 | Mitogen-activated protein kinase. (320 aa) |
| | HMGB1 | Uncharacterized protein. (215 aa) |
| | G1LQE5_AILME | HMG box domain-containing protein. (196 aa) |
| | MRNIP | MRN complex interacting protein. (337 aa) |
| | RGCC | Regulator of cell cycle. (134 aa) |
| | PRKD2 | Protein kinase D2. (878 aa) |
| | RIF1 | Replication timing regulatory factor 1. (2450 aa) |
| | GNL3 | G protein nucleolar 3. (550 aa) |
| | CCDC117 | Coiled-coil domain containing 117. (217 aa) |
| | MBTD1 | Mbt domain containing 1. (651 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1060 aa) |
| | KHDC3L | KH domain containing 3 like, subcortical maternal complex member. (225 aa) |
| | OOEP | Oocyte expressed protein. (149 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (712 aa) |
| | DERPC | DERPC proline and glycine rich nuclear protein. (529 aa) |
| | BCL7C | BAF chromatin remodeling complex subunit BCL7C. (214 aa) |
| | TRIM28 | Tripartite motif containing 28. (772 aa) |
| | CHTF18 | Chromosome transmission fidelity factor 18. (1114 aa) |
| | UIMC1 | Ubiquitin interaction motif containing 1. (674 aa) |
| | G1LL71_AILME | Ribosomal_S3_C domain-containing protein. (234 aa) |
| | E2F7 | E2F transcription factor 7. (909 aa) |
| | FUS | FUS RNA binding protein. (511 aa) |
| | WT1 | WT1 transcription factor. (403 aa) |
| | USP9X | Ubiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2555 aa) |
| | G1LJV2_AILME | Uncharacterized protein. (158 aa) |
| | FANCB | FA complementation group B. (867 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa) |
| | STPG4 | Sperm-tail PG-rich repeat containing 4. (173 aa) |
| | TNKS | Poly [ADP-ribose] polymerase. (1328 aa) |
| | ING3 | Inhibitor of growth protein. (418 aa) |
| | IL2 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (155 aa) |
| | TOX | Thymocyte selection associated high mobility group box. (527 aa) |
| | ATAD5 | ATPase family AAA domain containing 5. (1851 aa) |
| | PRIM2 | Uncharacterized protein. (276 aa) |
| | ANKRD39 | Ankyrin repeat domain 39. (184 aa) |
| | FAM178B | Family with sequence similarity 178 member B. (648 aa) |
| | NOX4 | NADPH oxidase 4. (603 aa) |
| | GREM1 | Gremlin 1, DAN family BMP antagonist. (238 aa) |
| | SMOC2 | SPARC related modular calcium binding 2. (433 aa) |
| | EXOSC3 | Exosome component 3. (275 aa) |
| | HELQ | Helicase, POLQ like. (1004 aa) |
| | ABRAXAS1 | Abraxas 1, BRCA1 A complex subunit. (409 aa) |
| | GLI1 | GLI family zinc finger 1. (1105 aa) |
| | FOXM1 | Forkhead box M1. (767 aa) |
| | EPC2 | Enhancer of polycomb homolog. (807 aa) |
| | TBX21 | T-box transcription factor 21. (439 aa) |
| | STAT6 | Signal transducer and activator of transcription. (844 aa) |
| | TFPT | TCF3 fusion partner. (253 aa) |
| | PRKCG | Protein kinase C gamma; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (697 aa) |
| | XRCC1 | X-ray repair cross complementing 1. (643 aa) |
| | ERCC8 | ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (396 aa) |
| | TIMELESS | Timeless circadian regulator. (1207 aa) |
| | TFRC | Transferrin receptor. (770 aa) |
| | G1LAZ0_AILME | MRG domain-containing protein. (263 aa) |
| | RNF168 | Ring finger protein 168. (569 aa) |
| | KMT5C | Lysine methyltransferase 5C. (461 aa) |
| | NABP2 | Nucleic acid binding protein 2. (211 aa) |
| | CCT4 | T-complex protein 1 subunit delta. (539 aa) |
| | G1LA13_AILME | Nucleoplasmin domain-containing protein. (218 aa) |
| | XRCC5 | X-ray repair cross complementing 5. (734 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa) |
| | INO80D | INO80 complex subunit D. (1030 aa) |
| | DKC1 | Dyskerin pseudouridine synthase 1. (507 aa) |
| | POLG2 | DNA polymerase gamma 2, accessory subunit. (485 aa) |
| | GINS4 | GINS complex subunit 4. (223 aa) |
| | CTC1 | CST telomere replication complex component 1. (1214 aa) |
| | NFRKB | Nuclear factor related to kappaB binding protein. (1298 aa) |
| | ACTR8 | Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize (By similarity); Belongs to the actin family. ARP8 subfamily. (624 aa) |
| | HDAC10 | Histone deacetylase 10. (669 aa) |
| | PIAS4 | Protein inhibitor of activated STAT 4. (518 aa) |
| | DHX9 | DExH-box helicase 9. (1276 aa) |
| | SIRT6 | Sirtuin 6. (361 aa) |
| | DSCC1 | DNA replication and sister chromatid cohesion 1. (393 aa) |
| | HDGFL2 | HDGF like 2. (643 aa) |
| | UBE2V2 | Ubiquitin conjugating enzyme E2 V2. (147 aa) |
| | G1L496_AILME | Uncharacterized protein. (1131 aa) |
| | UCN | Urocortin. (123 aa) |
| | PRDM7 | PR/SET domain 7. (475 aa) |
| | SPIRE2 | Spire type actin nucleation factor 2. (637 aa) |
| | KMT5B | Lysine methyltransferase 5B. (880 aa) |
| | PAXIP1 | PAX interacting protein 1. (1249 aa) |
| | G1L332_AILME | Nucleoplasmin domain-containing protein. (172 aa) |
| | DBF4 | DBF4-type domain-containing protein. (681 aa) |
| | NEK2 | NIMA related kinase 2. (443 aa) |
| | WDR48 | WD repeat domain 48. (677 aa) |
| | MYCN | MYCN proto-oncogene, bHLH transcription factor. (464 aa) |
| | MEAF6 | MYST/Esa1 associated factor 6. (172 aa) |
| | RFC4 | Replication factor C subunit 4. (365 aa) |
| | MCRS1 | Microspherule protein 1. (475 aa) |
| | VPS72 | YL1_C domain-containing protein. (364 aa) |
| | CLCF1 | Cardiotrophin like cytokine factor 1. (225 aa) |
| | POGZ | Pogo transposable element derived with ZNF domain. (1374 aa) |
| | FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa) |
| | CDC7 | Cell division cycle 7. (578 aa) |
| | APLF | Aprataxin and PNKP like factor. (480 aa) |
| | CDT1 | Chromatin licensing and DNA replication factor 1. (526 aa) |
| | BRPF3 | Bromodomain and PHD finger containing 3. (1207 aa) |
| | PRKDC | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2279 aa) |
| | SPIDR | DUF4503 domain-containing protein. (356 aa) |
| | PANDA_016575 | DUF4502 domain-containing protein. (186 aa) |
| | G1L053_AILME | DUF4502 domain-containing protein. (170 aa) |
| | MMS19 | MMS19 homolog, cytosolic iron-sulfur assembly component. (1046 aa) |
