STRINGSTRING
CYP27B1 CYP27B1 SZT2 SZT2 INS-IGF2 INS-IGF2 NDUFA4 NDUFA4 EDN1 EDN1 SIRT3 SIRT3 TACO1 TACO1 RFK RFK PARK7 PARK7 LEP LEP NDUFA4L2 NDUFA4L2 SIRT4 SIRT4 PIK3CB PIK3CB NUS1 NUS1 NPR3 NPR3 NOD2 NOD2 FXN FXN G1LK46_AILME G1LK46_AILME G1LK54_AILME G1LK54_AILME COX17 COX17 PDPR PDPR CDH3 CDH3 FCER2 FCER2 IFNG IFNG ETFBKMT ETFBKMT TNF TNF GZMA GZMA CCS CCS POR POR ESR1 ESR1 FDX2 FDX2 S100A1 S100A1 CAV3 CAV3 PDP1 PDP1 EDN3 EDN3 APOE APOE VDR VDR PHB2 PHB2 GFI1 GFI1 NOSIP NOSIP GCH1 GCH1 ABL2 ABL2 G1M8A2_AILME G1M8A2_AILME SPHK2 SPHK2 GDNF GDNF G1MA08_AILME G1MA08_AILME SCARB1 SCARB1 FGF23 FGF23 DHFR DHFR LRRK2 LRRK2 PRKN PRKN PANDA_009467 PANDA_009467 G1MBM7_AILME G1MBM7_AILME RIPK3 RIPK3 ABL1 ABL1 HTR2B HTR2B MT3 MT3 CYP27C1 CYP27C1 ATP7A ATP7A SLC4A1 SLC4A1 DRD5 DRD5 PANDA_000229 PANDA_000229 ENSAMEP00000020580 ENSAMEP00000020580 PDP2 PDP2 PANDA_011596 PANDA_011596 ECSIT ECSIT PTK2B PTK2B EDN2 EDN2 ATP2B4 ATP2B4 CAV1 CAV1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (511 aa)
SZT2SZT2 subunit of KICSTOR complex. (3423 aa)
INS-IGF2INS-IGF2 readthrough; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (212 aa)
NDUFA4Uncharacterized protein. (82 aa)
EDN1Endothelin 1. (169 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (337 aa)
TACO1Translational activator of cytochrome c oxidase I. (298 aa)
RFKRiboflavin kinase. (155 aa)
PARK7Parkinsonism associated deglycase. (189 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
NDUFA4L2NDUFA4 mitochondrial complex associated like 2. (87 aa)
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (314 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1071 aa)
NUS1NUS1 dehydrodolichyl diphosphate synthase subunit. (265 aa)
NPR3Natriuretic peptide receptor 3. (351 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1015 aa)
FXNFrataxin. (211 aa)
G1LK46_AILMEAmine oxidase. (760 aa)
G1LK54_AILMEAmine oxidase. (729 aa)
COX17Cytochrome c oxidase copper chaperone COX17. (63 aa)
PDPRPyruvate dehydrogenase phosphatase regulatory subunit. (762 aa)
CDH3Cadherin 3; Cadherins are calcium-dependent cell adhesion proteins. (839 aa)
FCER2Fc fragment of IgE receptor II. (321 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
ETFBKMTElectron transfer flavoprotein subunit beta lysine methyltransferase. (266 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
GZMAGranzyme A; Belongs to the peptidase S1 family. (260 aa)
CCSCopper chaperone for superoxide dismutase. (274 aa)
PORNADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (684 aa)
ESR1Estrogen receptor 1. (449 aa)
FDX22Fe-2S ferredoxin-type domain-containing protein. (186 aa)
S100A1Protein S100; Belongs to the S-100 family. (103 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (154 aa)
PDP1Pyruvate dehyrogenase phosphatase catalytic subunit 1. (588 aa)
EDN3Endothelin 3. (198 aa)
APOEApolipoprotein E. (311 aa)
VDRVitamin D receptor. (445 aa)
PHB2Prohibitin. (299 aa)
GFI1Uncharacterized protein. (192 aa)
NOSIPNitric oxide synthase-interacting protein; Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity; Belongs to the NOSIP family. (314 aa)
GCH1GTP_cyclohydroI domain-containing protein. (158 aa)
ABL2Tyrosine-protein kinase. (1109 aa)
G1M8A2_AILMEzf-NOSIP domain-containing protein. (250 aa)
SPHK2Sphingosine kinase 2. (663 aa)
GDNFGlial cell derived neurotrophic factor. (224 aa)
G1MA08_AILMEGTP_cyclohydroI domain-containing protein. (100 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (509 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (245 aa)
DHFRDHFR domain-containing protein; Belongs to the dihydrofolate reductase family. (187 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
PRKNUbiquitin-like domain-containing protein. (287 aa)
PANDA_009467zf-RING_14 domain-containing protein. (74 aa)
G1MBM7_AILMERBR-type E3 ubiquitin transferase. (105 aa)
RIPK3Receptor interacting serine/threonine kinase 3; Belongs to the protein kinase superfamily. (480 aa)
ABL1Tyrosine-protein kinase. (1150 aa)
HTR2B5-hydroxytryptamine receptor 2B. (480 aa)
MT3Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (68 aa)
CYP27C1Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family. (476 aa)
ATP7AATPase copper transporting alpha. (1460 aa)
SLC4A1Anion exchange protein. (933 aa)
DRD5Dopamine receptor D5; Belongs to the G-protein coupled receptor 1 family. (441 aa)
PANDA_000229Uncharacterized protein. (82 aa)
ENSAMEP00000020580annotation not available (64 aa)
PDP2Pyruvate dehyrogenase phosphatase catalytic subunit 2. (531 aa)
PANDA_011596Uncharacterized protein. (65 aa)
ECSITECSIT signalling integrator. (437 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1011 aa)
EDN2Endothelin 2. (178 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1249 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
Your Current Organism:
Ailuropoda melanoleuca
NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda
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