(14 nodes) Dendritic spine morphogenesis network (Ailuropoda melanoleuca)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EPHB2	EPH receptor B2. (968 aa)
	DLG4	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (761 aa)
	EPHB1	EPH receptor B1. (945 aa)
	PTEN	Phosphatase and tensin homolog. (403 aa)
	PAK3	P21 (RAC1) activated kinase 3. (580 aa)
	DOCK10	Dedicator of cytokinesis 10; Belongs to the DOCK family. (2178 aa)
	G1LH72_AILME	Uncharacterized protein. (186 aa)
	SHANK1	SH3 and multiple ankyrin repeat domains 1. (1687 aa)
	SHANK3	SH3 and multiple ankyrin repeat domains 3. (1644 aa)
	WASL	WASP like actin nucleation promoting factor. (499 aa)
	HDAC6	Histone deacetylase 6. (1174 aa)
	ZNF365	Zinc finger protein 365. (407 aa)
	EPHB3	EPH receptor B3. (999 aa)
	CDC42	Cell division cycle 42. (231 aa)

Your Current Organism:

Ailuropoda melanoleuca

NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC42	DOCK10	ENSAMEP00000015397	ENSAMEP00000012222	Cell division cycle 42.	Dedicator of cytokinesis 10; Belongs to the DOCK family.	0.837
CDC42	PAK3	ENSAMEP00000015397	ENSAMEP00000012732	Cell division cycle 42.	P21 (RAC1) activated kinase 3.	0.909
CDC42	PTEN	ENSAMEP00000015397	ENSAMEP00000000745	Cell division cycle 42.	Phosphatase and tensin homolog.	0.438
CDC42	SHANK1	ENSAMEP00000015397	ENSAMEP00000013610	Cell division cycle 42.	SH3 and multiple ankyrin repeat domains 1.	0.416
CDC42	SHANK3	ENSAMEP00000015397	ENSAMEP00000003318	Cell division cycle 42.	SH3 and multiple ankyrin repeat domains 3.	0.441
CDC42	WASL	ENSAMEP00000015397	ENSAMEP00000004800	Cell division cycle 42.	WASP like actin nucleation promoting factor.	0.948
DLG4	SHANK1	ENSAMEP00000017365	ENSAMEP00000013610	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	SH3 and multiple ankyrin repeat domains 1.	0.744
DLG4	SHANK3	ENSAMEP00000017365	ENSAMEP00000003318	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	SH3 and multiple ankyrin repeat domains 3.	0.717
DOCK10	CDC42	ENSAMEP00000012222	ENSAMEP00000015397	Dedicator of cytokinesis 10; Belongs to the DOCK family.	Cell division cycle 42.	0.837
DOCK10	G1LH72_AILME	ENSAMEP00000012222	ENSAMEP00000006266	Dedicator of cytokinesis 10; Belongs to the DOCK family.	Uncharacterized protein.	0.837
EPHB3	PAK3	ENSAMEP00000017884	ENSAMEP00000012732	EPH receptor B3.	P21 (RAC1) activated kinase 3.	0.406
EPHB3	WASL	ENSAMEP00000017884	ENSAMEP00000004800	EPH receptor B3.	WASP like actin nucleation promoting factor.	0.447
G1LH72_AILME	DOCK10	ENSAMEP00000006266	ENSAMEP00000012222	Uncharacterized protein.	Dedicator of cytokinesis 10; Belongs to the DOCK family.	0.837
G1LH72_AILME	PAK3	ENSAMEP00000006266	ENSAMEP00000012732	Uncharacterized protein.	P21 (RAC1) activated kinase 3.	0.909
G1LH72_AILME	PTEN	ENSAMEP00000006266	ENSAMEP00000000745	Uncharacterized protein.	Phosphatase and tensin homolog.	0.438
G1LH72_AILME	SHANK1	ENSAMEP00000006266	ENSAMEP00000013610	Uncharacterized protein.	SH3 and multiple ankyrin repeat domains 1.	0.416
G1LH72_AILME	SHANK3	ENSAMEP00000006266	ENSAMEP00000003318	Uncharacterized protein.	SH3 and multiple ankyrin repeat domains 3.	0.441
G1LH72_AILME	WASL	ENSAMEP00000006266	ENSAMEP00000004800	Uncharacterized protein.	WASP like actin nucleation promoting factor.	0.948
PAK3	CDC42	ENSAMEP00000012732	ENSAMEP00000015397	P21 (RAC1) activated kinase 3.	Cell division cycle 42.	0.909
PAK3	EPHB3	ENSAMEP00000012732	ENSAMEP00000017884	P21 (RAC1) activated kinase 3.	EPH receptor B3.	0.406