STRINGSTRING
SETDB1 SETDB1 SIRT6 SIRT6 DNMT3A DNMT3A EZH2 EZH2 HP1BP3 HP1BP3 LOXL2 LOXL2 TNP1 TNP1 SETDB2 SETDB2 MBD3 MBD3 RB1 RB1 BAZ2A BAZ2A CENPV CENPV DOT1L DOT1L LMNB2 LMNB2 LOXL4 LOXL4 FAM172A FAM172A EZH1 EZH1 AXIN1 AXIN1 HDAC1 HDAC1 BEND3 BEND3 PPM1D PPM1D RIF1 RIF1 HAT1 HAT1 G1LQE5_AILME G1LQE5_AILME HMGB1 HMGB1 SMARCA5 SMARCA5 GALK1 GALK1 LOC100470602 LOC100470602 MTHFR MTHFR SMCHD1 SMCHD1 LMNB1 LMNB1 G1LWH9_AILME G1LWH9_AILME SETD7 SETD7 G1LYU2_AILME G1LYU2_AILME DNMT1 DNMT1 UBR2 UBR2 POLE3 POLE3 NRM NRM HDAC2 HDAC2 SNAI1 SNAI1 HELLS HELLS ZNFX1 ZNFX1 LMNA LMNA H3-3A H3-3A RRP8 RRP8 CTBP1 CTBP1 BAHD1 BAHD1 MBD2 MBD2 SPTY2D1 SPTY2D1 SIRT1 SIRT1 MECP2 MECP2 MBD3L1 MBD3L1 G1MM36_AILME G1MM36_AILME LOC100469071 LOC100469071
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SETDB1SET domain bifurcated histone lysine methyltransferase 1. (1298 aa)
SIRT6Sirtuin 6. (361 aa)
DNMT3ADNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (912 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (751 aa)
HP1BP3Heterochromatin protein 1 binding protein 3. (553 aa)
LOXL2Lysyl oxidase like 2. (772 aa)
TNP1Transition protein 1. (55 aa)
SETDB2SET domain bifurcated histone lysine methyltransferase 2. (996 aa)
MBD3Methyl-CpG binding domain protein 3. (259 aa)
RB1RB transcriptional corepressor 1. (906 aa)
BAZ2ABromodomain adjacent to zinc finger domain 2A. (1922 aa)
CENPVGFA domain-containing protein. (151 aa)
DOT1LHistone-lysine N-methyltransferase, H3 lysine-79 specific. (1665 aa)
LMNB2Lamin B2; Belongs to the intermediate filament family. (583 aa)
LOXL4Lysyl oxidase like 4. (896 aa)
FAM172AFamily with sequence similarity 172 member A. (416 aa)
EZH1Enhancer of zeste 1 polycomb repressive complex 2 subunit. (758 aa)
AXIN1Axin 1. (866 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (485 aa)
BEND3BEN domain containing 3. (828 aa)
PPM1DProtein phosphatase, Mg2+/Mn2+ dependent 1D. (641 aa)
RIF1Replication timing regulatory factor 1. (2450 aa)
HAT1Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. (419 aa)
G1LQE5_AILMEHMG box domain-containing protein. (196 aa)
HMGB1Uncharacterized protein. (215 aa)
SMARCA5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1052 aa)
GALK1Galactokinase 1. (391 aa)
LOC100470602Histone H3; Belongs to the histone H3 family. (136 aa)
MTHFRMethylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (695 aa)
SMCHD1Structural maintenance of chromosomes flexible hinge domain containing 1. (1988 aa)
LMNB1Lamin B1; Belongs to the intermediate filament family. (579 aa)
G1LWH9_AILMEPHD-type domain-containing protein. (387 aa)
SETD7Histone-lysine N-methyltransferase SETD7; Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes. (373 aa)
G1LYU2_AILMEUncharacterized protein. (199 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1614 aa)
UBR2E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1651 aa)
POLE3DNA polymerase epsilon 3, accessory subunit. (147 aa)
NRMNurim. (262 aa)
HDAC2Histone deacetylase 2. (578 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
HELLSHelicase, lymphoid specific. (838 aa)
ZNFX1Zinc finger NFX1-type containing 1. (1919 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (642 aa)
H3-3AHistone H3.3. (136 aa)
RRP8Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] (504 aa)
CTBP1C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (438 aa)
BAHD1Bromo adjacent homology domain containing 1. (774 aa)
MBD2Methyl-CpG binding domain protein 2. (287 aa)
SPTY2D1SPT2 chromatin protein domain containing 1. (704 aa)
SIRT1Sirtuin 1. (607 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (483 aa)
MBD3L1Methyl-CpG binding domain protein 3 like 1. (187 aa)
G1MM36_AILMEUncharacterized protein. (127 aa)
LOC100469071Uncharacterized protein. (356 aa)
Your Current Organism:
Ailuropoda melanoleuca
NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda
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