(21 nodes) Regulation of cardiac muscle cell contraction network (Ailuropoda melanoleuca)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	G1LA03_AILME	Uncharacterized protein. (99 aa)
	RYR2	Ryanodine receptor 2. (4911 aa)
	RANGRF	RAN guanine nucleotide release factor. (193 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	SRI	Sorcin. (194 aa)
	GJA5	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
	PLN	Phospholamban. (52 aa)
	CTNNA3	Uncharacterized protein. (193 aa)
	PDE4B	Phosphodiesterase. (735 aa)
	SCN5A	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2010 aa)
	LOC105234678	Uncharacterized protein. (181 aa)
	ATP2A1	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1046 aa)
	TRPM4	Transient receptor potential cation channel subfamily M member 4. (1115 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (154 aa)
	G1LS85_AILME	MAGUK_N_PEST domain-containing protein. (118 aa)
	PKP2	Plakophilin 2. (882 aa)
	DLG2	Uncharacterized protein. (452 aa)
	JUP	Junction plakoglobin. (779 aa)
	G1LFE2_AILME	Uncharacterized protein. (328 aa)
	DLG1	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (766 aa)
	PDE4D	Phosphodiesterase. (665 aa)

Your Current Organism:

Ailuropoda melanoleuca

NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATP2A1	PLN	ENSAMEP00000016501	ENSAMEP00000019897	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Phospholamban.	0.984
ATP2A1	RYR2	ENSAMEP00000016501	ENSAMEP00000003073	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Ryanodine receptor 2.	0.514
CAV1	CAV3	ENSAMEP00000001406	ENSAMEP00000013002	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.954
CAV1	JUP	ENSAMEP00000001406	ENSAMEP00000006002	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Junction plakoglobin.	0.458
CAV1	SRI	ENSAMEP00000001406	ENSAMEP00000001344	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Sorcin.	0.515
CAV3	CAV1	ENSAMEP00000013002	ENSAMEP00000001406	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.954
CAV3	JUP	ENSAMEP00000013002	ENSAMEP00000006002	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Junction plakoglobin.	0.407
CAV3	RYR2	ENSAMEP00000013002	ENSAMEP00000003073	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Ryanodine receptor 2.	0.578
CAV3	SCN5A	ENSAMEP00000013002	ENSAMEP00000018684	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.401
CTNNA3	JUP	ENSAMEP00000019157	ENSAMEP00000006002	Uncharacterized protein.	Junction plakoglobin.	0.790
CTNNA3	LOC105234678	ENSAMEP00000019157	ENSAMEP00000018117	Uncharacterized protein.	Uncharacterized protein.	0.878
CTNNA3	PKP2	ENSAMEP00000019157	ENSAMEP00000009364	Uncharacterized protein.	Plakophilin 2.	0.547
DLG1	DLG2	ENSAMEP00000003790	ENSAMEP00000009143	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family.	Uncharacterized protein.	0.900
DLG2	DLG1	ENSAMEP00000009143	ENSAMEP00000003790	Uncharacterized protein.	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family.	0.900
DLG2	G1LFE2_AILME	ENSAMEP00000009143	ENSAMEP00000005630	Uncharacterized protein.	Uncharacterized protein.	0.876
G1LA03_AILME	RYR2	ENSAMEP00000003726	ENSAMEP00000003073	Uncharacterized protein.	Ryanodine receptor 2.	0.470
G1LFE2_AILME	DLG2	ENSAMEP00000005630	ENSAMEP00000009143	Uncharacterized protein.	Uncharacterized protein.	0.876
GJA5	RYR2	ENSAMEP00000021349	ENSAMEP00000003073	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Ryanodine receptor 2.	0.436
GJA5	SCN5A	ENSAMEP00000021349	ENSAMEP00000018684	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.609
JUP	CAV1	ENSAMEP00000006002	ENSAMEP00000001406	Junction plakoglobin.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.458