STRINGSTRING
SNAI2 SNAI2 SFRP5 SFRP5 STK3 STK3 PTPRU PTPRU ANKRD6 ANKRD6 DAB2IP DAB2IP SOX13 SOX13 FRZB FRZB CAV1 CAV1 GPC3 GPC3 G1L3P7_AILME G1L3P7_AILME CTHRC1 CTHRC1 CCDC88C CCDC88C G1L4E7_AILME G1L4E7_AILME DKK2 DKK2 TLE7 TLE7 DACT1 DACT1 TMEM170B TMEM170B SFRP1 SFRP1 NOG NOG STK11 STK11 DKK1 DKK1 G1L9K7_AILME G1L9K7_AILME PTPRO PTPRO NOTCH1 NOTCH1 CTNNBIP1 CTNNBIP1 STK4 STK4 UBAC2 UBAC2 GLI1 GLI1 DDIT3 DDIT3 DKK4 DKK4 GREM1 GREM1 CSNK1A1 CSNK1A1 TLE6 TLE6 TLE2 TLE2 DKK3 DKK3 RBMS3 RBMS3 FZD4 FZD4 CHD8 CHD8 NKD1 NKD1 CYLD CYLD LMBR1L LMBR1L GSK3B GSK3B AXIN1 AXIN1 LRP4 LRP4 EMD EMD G3BP1 G3BP1 FOXO3 FOXO3 NKD2 NKD2 KREMEN1 KREMEN1 GLI3 GLI3 DACT3 DACT3 TLE4 TLE4 SIAH2 SIAH2 G1LT03_AILME G1LT03_AILME MAD2L2 MAD2L2 DRAXIN DRAXIN SOX10 SOX10 WWTR1 WWTR1 SOSTDC1 SOSTDC1 BMP2 BMP2 JADE1 JADE1 FERMT1 FERMT1 CBY1 CBY1 ACAD11 ACAD11 SOX17 SOX17 AXIN2 AXIN2 PFDN5 PFDN5 OTUD5 OTUD5 MCC MCC APC APC APOE APOE SHISA3 SHISA3 G1M304_AILME G1M304_AILME MESP1 MESP1 BICC1 BICC1 PRICKLE1 PRICKLE1 DKKL1 DKKL1 AMER2 AMER2 SFRP4 SFRP4 RUVBL2 RUVBL2 TLE1 TLE1 CTNND1 CTNND1 LATS2 LATS2 TMEM64 TMEM64 INVS INVS SCYL2 SCYL2 TCF7L2 TCF7L2 NPHP4 NPHP4 PRKN PRKN PANDA_009467 PANDA_009467 G1MBM7_AILME G1MBM7_AILME TLE3 TLE3 RAPGEF1 RAPGEF1 EGR1 EGR1 SDHAF2 SDHAF2 AMFR AMFR G1MER5_AILME G1MER5_AILME WNT11 WNT11 SOX9 SOX9 DAB2 DAB2 NOTUM NOTUM FRMD8 FRMD8 LZTS2 LZTS2 LATS1 LATS1 SOST SOST TMEM131L TMEM131L SFRP2 SFRP2 AMER1 AMER1 G1MN16_AILME G1MN16_AILME TPBGL TPBGL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SNAI2Snail family transcriptional repressor 2. (268 aa)
SFRP5Secreted frizzled related protein 5. (296 aa)
STK3Serine/threonine kinase 3. (483 aa)
PTPRUProtein tyrosine phosphatase receptor type U. (1447 aa)
ANKRD6Ankyrin repeat domain 6. (727 aa)
DAB2IPDAB2 interacting protein. (990 aa)
SOX13SRY-box transcription factor 13. (633 aa)
FRZBFZ domain-containing protein. (168 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (580 aa)
G1L3P7_AILMENTF2 domain-containing protein. (428 aa)
CTHRC1Collagen triple helix repeat containing 1. (221 aa)
CCDC88CCalponin-homology (CH) domain-containing protein. (1559 aa)
G1L4E7_AILMEUncharacterized protein. (460 aa)
DKK2Dickkopf WNT signaling pathway inhibitor 2. (259 aa)
TLE7TLE family member 7. (309 aa)
DACT1Dishevelled binding antagonist of beta catenin 1. (694 aa)
TMEM170BTransmembrane protein 170B. (132 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
NOGNoggin. (206 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (443 aa)
DKK1Dickkopf-like protein 1. (268 aa)
G1L9K7_AILMEUncharacterized protein. (659 aa)
PTPROProtein tyrosine phosphatase receptor type O. (1206 aa)
NOTCH1Notch receptor 1. (2435 aa)
CTNNBIP1Catenin beta interacting protein 1. (82 aa)
STK4Serine/threonine kinase 4. (487 aa)
UBAC2UBA domain containing 2. (347 aa)
GLI1GLI family zinc finger 1. (1105 aa)
DDIT3DNA damage inducible transcript 3. (168 aa)
DKK4Dickkopf WNT signaling pathway inhibitor 4. (221 aa)
GREM1Gremlin 1, DAN family BMP antagonist. (238 aa)
CSNK1A1Casein kinase 1 alpha 1; Belongs to the protein kinase superfamily. (364 aa)
TLE6TLE family member 6, subcortical maternal complex member. (453 aa)
TLE2TLE family member 2, transcriptional corepressor. (759 aa)
DKK3Dickkopf WNT signaling pathway inhibitor 3. (291 aa)
RBMS3RNA binding motif single stranded interacting protein 3. (303 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
CHD8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2586 aa)
NKD1NKD inhibitor of WNT signaling pathway 1. (462 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
LMBR1LLimb development membrane protein 1 like; Belongs to the LIMR family. (488 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
AXIN1Axin 1. (866 aa)
LRP4LDL receptor related protein 4. (1888 aa)
EMDEmerin. (260 aa)
G3BP1Uncharacterized protein. (477 aa)
FOXO3Forkhead box O3. (534 aa)
NKD2NKD inhibitor of WNT signaling pathway 2. (398 aa)
KREMEN1Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (440 aa)
GLI3GLI family zinc finger 3. (1586 aa)
DACT3Uncharacterized protein. (127 aa)
TLE4TLE family member 4, transcriptional corepressor. (700 aa)
SIAH2E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (331 aa)
G1LT03_AILMENTR domain-containing protein. (151 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (211 aa)
DRAXINDorsal inhibitory axon guidance protein. (348 aa)
SOX10SRY-box transcription factor 10. (442 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
SOSTDC1Sclerostin domain containing 1. (206 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
JADE1Jade family PHD finger 1. (843 aa)
FERMT1Fermitin family member 1. (677 aa)
CBY1Chibby family member 1, beta catenin antagonist. (131 aa)
ACAD11TPR_REGION domain-containing protein. (1356 aa)
SOX17SRY-box transcription factor 17. (399 aa)
AXIN2Axin 2. (841 aa)
PFDN5Uncharacterized protein. (160 aa)
OTUD5OTU deubiquitinase 5. (511 aa)
MCCMCC regulator of WNT signaling pathway. (826 aa)
APCAPC regulator of WNT signaling pathway. (2848 aa)
APOEApolipoprotein E. (311 aa)
SHISA3Shisa family member 3. (236 aa)
G1M304_AILMEUncharacterized protein. (281 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (185 aa)
BICC1BicC family RNA binding protein 1. (914 aa)
PRICKLE1Prickle planar cell polarity protein 1. (832 aa)
DKKL1Dickkopf like acrosomal protein 1. (241 aa)
AMER2APC membrane recruitment protein 2. (604 aa)
SFRP4Secreted frizzled related protein 4. (348 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (467 aa)
TLE1TLE family member 1, transcriptional corepressor. (778 aa)
CTNND1Catenin delta 1. (971 aa)
LATS2Large tumor suppressor kinase 2. (1084 aa)
TMEM64Transmembrane protein 64. (268 aa)
INVSInversin. (933 aa)
SCYL2SCY1 like pseudokinase 2. (929 aa)
TCF7L2Transcription factor 7 like 2. (485 aa)
NPHP4Nephrocystin 4. (1435 aa)
PRKNUbiquitin-like domain-containing protein. (287 aa)
PANDA_009467zf-RING_14 domain-containing protein. (74 aa)
G1MBM7_AILMERBR-type E3 ubiquitin transferase. (105 aa)
TLE3TLE family member 3, transcriptional corepressor. (839 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1187 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (541 aa)
SDHAF2Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. (159 aa)
AMFRAutocrine motility factor receptor. (560 aa)
G1MER5_AILMEUncharacterized protein. (112 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
SOX9SRY-box transcription factor 9. (521 aa)
DAB2DAB adaptor protein 2. (712 aa)
NOTUMNotum, palmitoleoyl-protein carboxylesterase. (465 aa)
FRMD8FERM domain containing 8. (465 aa)
LZTS2Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (649 aa)
LATS1Large tumor suppressor kinase 1. (1128 aa)
SOSTSclerostin. (183 aa)
TMEM131LTransmembrane 131 like. (1581 aa)
SFRP2Secreted frizzled related protein 2. (301 aa)
AMER1APC membrane recruitment protein 1. (1134 aa)
G1MN16_AILMEUncharacterized protein. (152 aa)
TPBGLUncharacterized protein. (78 aa)
Your Current Organism:
Ailuropoda melanoleuca
NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda
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