(75 nodes) Positive regulation of canonical Wnt signaling pathway network (Ailuropoda melanoleuca)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	TRPM4	Transient receptor potential cation channel subfamily M member 4. (1115 aa)
	LGR4	Leucine rich repeat containing G protein-coupled receptor 4. (906 aa)
	NLE1	Notchless homolog 1. (486 aa)
	PLEKHA4	Pleckstrin homology domain containing A4. (791 aa)
	UBR5	Ubiquitin protein ligase E3 component n-recognin 5. (2795 aa)
	RUVBL1	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
	TBL1X	Uncharacterized protein. (526 aa)
	TTC21B	Tetratricopeptide repeat domain 21B. (1322 aa)
	XIAP	X-linked inhibitor of apoptosis. (497 aa)
	LRRK2	Leucine rich repeat kinase 2. (2527 aa)
	ILK	Integrin linked kinase. (452 aa)
	NRARP	NOTCH regulated ankyrin repeat protein. (114 aa)
	CTDNEP1	CTD nuclear envelope phosphatase 1. (246 aa)
	TMEM198	Transmembrane protein 198. (360 aa)
	GPC5	Glypican 5; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (411 aa)
	CSNK1D	Casein kinase 1 delta. (390 aa)
	GID8	GID complex subunit 8 homolog. (229 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (96 aa)
	USP34	Ubiquitin specific peptidase 34; Belongs to the peptidase C19 family. (3528 aa)
	SFRP2	Secreted frizzled related protein 2. (301 aa)
	AMER1	APC membrane recruitment protein 1. (1134 aa)
	RNF146	E3 ubiquitin-protein ligase RNF146; E3 ubiquitin-protein ligase that specifically binds poly-ADP- ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CA [...] (360 aa)
	CSNK1G1	Casein kinase 1 gamma 1; Belongs to the protein kinase superfamily. (459 aa)
	LGR5	Leucine rich repeat containing G protein-coupled receptor 5. (912 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa)
	RSPO1	R-spondin 1. (262 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	GPC3	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (580 aa)
	DKK2	Dickkopf WNT signaling pathway inhibitor 2. (259 aa)
	PRDM15	PR/SET domain 15. (1191 aa)
	PPM1M	Protein phosphatase, Mg2+/Mn2+ dependent 1M. (386 aa)
	CAPRIN2	Caprin family member 2. (1124 aa)
	RSPO3	R-spondin 3. (295 aa)
	RECK	Reversion inducing cysteine rich protein with kazal motifs. (971 aa)
	YAP1	Yes associated protein 1. (438 aa)
	LOC100473087	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (416 aa)
	TBL1XR1	Transducin beta like 1 X-linked receptor 1. (514 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	ADGRA2	Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1199 aa)
	SOX4	SRY-box transcription factor 4. (264 aa)
	DACT1	Dishevelled binding antagonist of beta catenin 1. (694 aa)
	FZD9	Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (462 aa)
	TMEM9	Transmembrane protein 9. (208 aa)
	SRC	Tyrosine-protein kinase. (542 aa)
	PIN1	Peptidyl-prolyl cis-trans isomerase. (164 aa)
	PPM1N	Protein phosphatase, Mg2+/Mn2+ dependent 1N (putative). (400 aa)
	PTK7	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1072 aa)
	SULF2	Sulfatase 2. (813 aa)
	RNF220	Ring finger protein 220. (567 aa)
	HHEX	Hematopoietically expressed homeobox. (262 aa)
	SFRP4	Secreted frizzled related protein 4. (348 aa)
	SFRP1	Secreted frizzled related protein 1. (314 aa)
	PPM1A	Protein phosphatase, Mg2+/Mn2+ dependent 1A. (455 aa)
	LOC100483491	DUF4203 domain-containing protein. (350 aa)
	CCAR2	Cell cycle and apoptosis regulator 2. (918 aa)
	LYPD6	LY6/PLAUR domain containing 6. (171 aa)
	GSKIP	GSK3B interacting protein. (144 aa)
	FAM53B	Family with sequence similarity 53 member B. (426 aa)
	WLS	Wnt ligand secretion mediator. (419 aa)
	ANKRD39	Ankyrin repeat domain 39. (184 aa)
	DLX5	Distal-less homeobox 5. (289 aa)
	PPM1B	PPM-type phosphatase domain-containing protein. (479 aa)
	USP47	Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1379 aa)
	TNKS	Poly [ADP-ribose] polymerase. (1328 aa)
	G1LJC6_AILME	Uncharacterized protein. (226 aa)
	KANK1	KN motif and ankyrin repeat domains 1. (1352 aa)
	DDX3X	DEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (675 aa)
	WNT10B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (404 aa)
	CDH3	Cadherin 3; Cadherins are calcium-dependent cell adhesion proteins. (839 aa)
	BAMBI	BMP and activin membrane bound inhibitor. (238 aa)
	LOC105234723	Uncharacterized protein. (97 aa)
	USP8	Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1119 aa)
	EDA	Ectodysplasin A; Belongs to the tumor necrosis factor family. (259 aa)
	LRRK1	Leucine rich repeat kinase 1. (1982 aa)
	TNKS2	Poly [ADP-ribose] polymerase. (1218 aa)

Your Current Organism:

Ailuropoda melanoleuca

NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADGRA2	LRRK2	ENSAMEP00000011558	ENSAMEP00000016680	Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family.	Leucine rich repeat kinase 2.	0.440
ADGRA2	RECK	ENSAMEP00000011558	ENSAMEP00000010483	Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family.	Reversion inducing cysteine rich protein with kazal motifs.	0.654
BAMBI	FZD9	ENSAMEP00000008506	ENSAMEP00000011748	BMP and activin membrane bound inhibitor.	Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family.	0.911
BAMBI	SFRP2	ENSAMEP00000008506	ENSAMEP00000019507	BMP and activin membrane bound inhibitor.	Secreted frizzled related protein 2.	0.464
CAV1	SRC	ENSAMEP00000001406	ENSAMEP00000012975	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Tyrosine-protein kinase.	0.985
CSNK1D	LOC100473087	ENSAMEP00000018198	ENSAMEP00000011102	Casein kinase 1 delta.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.967
CSNK1D	YAP1	ENSAMEP00000018198	ENSAMEP00000010528	Casein kinase 1 delta.	Yes associated protein 1.	0.906
CSNK1G1	RUVBL1	ENSAMEP00000002701	ENSAMEP00000015972	Casein kinase 1 gamma 1; Belongs to the protein kinase superfamily.	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.	0.436
DACT1	SFRP1	ENSAMEP00000002794	ENSAMEP00000002892	Dishevelled binding antagonist of beta catenin 1.	Secreted frizzled related protein 1.	0.435
DKK2	LGR5	ENSAMEP00000002049	ENSAMEP00000000553	Dickkopf WNT signaling pathway inhibitor 2.	Leucine rich repeat containing G protein-coupled receptor 5.	0.502
DKK2	SFRP1	ENSAMEP00000002049	ENSAMEP00000002892	Dickkopf WNT signaling pathway inhibitor 2.	Secreted frizzled related protein 1.	0.543
DKK2	SFRP2	ENSAMEP00000002049	ENSAMEP00000019507	Dickkopf WNT signaling pathway inhibitor 2.	Secreted frizzled related protein 2.	0.543
DKK2	SFRP4	ENSAMEP00000002049	ENSAMEP00000015031	Dickkopf WNT signaling pathway inhibitor 2.	Secreted frizzled related protein 4.	0.481
DKK2	WNT10B	ENSAMEP00000002049	ENSAMEP00000007404	Dickkopf WNT signaling pathway inhibitor 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.773
FGF10	FGF2	ENSAMEP00000000618	ENSAMEP00000018489	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.478
FGF10	RSPO1	ENSAMEP00000000618	ENSAMEP00000001117	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	R-spondin 1.	0.614
FGF10	SRC	ENSAMEP00000000618	ENSAMEP00000012975	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Tyrosine-protein kinase.	0.469
FGF2	FGF10	ENSAMEP00000018489	ENSAMEP00000000618	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.478
FGF2	LGR5	ENSAMEP00000018489	ENSAMEP00000000553	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Leucine rich repeat containing G protein-coupled receptor 5.	0.425
FGF2	SRC	ENSAMEP00000018489	ENSAMEP00000012975	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Tyrosine-protein kinase.	0.503