(23 nodes) Negative regulation of stem cell differentiation network (Ailuropoda melanoleuca)

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Your Input:
	NELFB	Negative elongation factor complex member B. (580 aa)
	CDK13	Cyclin dependent kinase 13. (1257 aa)
	TBX3	T-box transcription factor 3. (717 aa)
	EZH2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (751 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	NOTCH1	Notch receptor 1. (2435 aa)
	CDK12	Cyclin-dependent kinase 12; Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading [...] (1491 aa)
	STAT3	Signal transducer and activator of transcription. (771 aa)
	G1LIM1_AILME	Homeobox domain-containing protein. (261 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
	G1LP14_AILME	Uncharacterized protein. (65 aa)
	PRICKLE1	Prickle planar cell polarity protein 1. (832 aa)
	G1M3G2_AILME	Orange domain-containing protein. (117 aa)
	NFE2L2	Nuclear factor, erythroid 2 like 2. (610 aa)
	YTHDF2	YTH N6-methyladenosine RNA binding protein 2. (581 aa)
	YAP1	Yes associated protein 1. (438 aa)
	HNRNPU	Heterogeneous nuclear ribonucleoprotein U. (821 aa)
	REST	RE1 silencing transcription factor. (1038 aa)
	ZFP36	ZFP36 ring finger protein. (325 aa)
	HES1	Hes family bHLH transcription factor 1. (216 aa)
	HSPA9	Heat shock protein family A (Hsp70) member 9; Belongs to the heat shock protein 70 family. (683 aa)
	NANOG	Homeobox domain-containing protein. (306 aa)
	BBS12	Bardet-Biedl syndrome 12. (713 aa)

Your Current Organism:

Ailuropoda melanoleuca

NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDK12	CDK13	ENSAMEP00000004181	ENSAMEP00000008807	Cyclin-dependent kinase 12; Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading [...]	Cyclin dependent kinase 13.	0.402
CDK12	NELFB	ENSAMEP00000004181	ENSAMEP00000017285	Cyclin-dependent kinase 12; Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading [...]	Negative elongation factor complex member B.	0.508
CDK13	CDK12	ENSAMEP00000008807	ENSAMEP00000004181	Cyclin dependent kinase 13.	Cyclin-dependent kinase 12; Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading [...]	0.402
CDK13	NELFB	ENSAMEP00000008807	ENSAMEP00000017285	Cyclin dependent kinase 13.	Negative elongation factor complex member B.	0.474
EZH2	G1LIM1_AILME	ENSAMEP00000003001	ENSAMEP00000006774	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	Homeobox domain-containing protein.	0.411
EZH2	NANOG	ENSAMEP00000003001	ENSAMEP00000018023	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	Homeobox domain-containing protein.	0.411
EZH2	NOTCH1	ENSAMEP00000003001	ENSAMEP00000004158	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	Notch receptor 1.	0.478
EZH2	STAT3	ENSAMEP00000003001	ENSAMEP00000006689	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	Signal transducer and activator of transcription.	0.717
G1LIM1_AILME	EZH2	ENSAMEP00000006774	ENSAMEP00000003001	Homeobox domain-containing protein.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.411
G1LIM1_AILME	GSK3B	ENSAMEP00000006774	ENSAMEP00000007366	Homeobox domain-containing protein.	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	0.438
G1LIM1_AILME	NOTCH1	ENSAMEP00000006774	ENSAMEP00000004158	Homeobox domain-containing protein.	Notch receptor 1.	0.452
G1LIM1_AILME	STAT3	ENSAMEP00000006774	ENSAMEP00000006689	Homeobox domain-containing protein.	Signal transducer and activator of transcription.	0.570
G1LIM1_AILME	TBX3	ENSAMEP00000006774	ENSAMEP00000001157	Homeobox domain-containing protein.	T-box transcription factor 3.	0.666
G1LP14_AILME	NELFB	ENSAMEP00000008794	ENSAMEP00000017285	Uncharacterized protein.	Negative elongation factor complex member B.	0.474
G1M3G2_AILME	JAG1	ENSAMEP00000013874	ENSAMEP00000003990	Orange domain-containing protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.644
G1M3G2_AILME	NOTCH1	ENSAMEP00000013874	ENSAMEP00000004158	Orange domain-containing protein.	Notch receptor 1.	0.650
GSK3B	G1LIM1_AILME	ENSAMEP00000007366	ENSAMEP00000006774	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	Homeobox domain-containing protein.	0.438
GSK3B	NANOG	ENSAMEP00000007366	ENSAMEP00000018023	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	Homeobox domain-containing protein.	0.438
GSK3B	NFE2L2	ENSAMEP00000007366	ENSAMEP00000012560	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	Nuclear factor, erythroid 2 like 2.	0.930
GSK3B	NOTCH1	ENSAMEP00000007366	ENSAMEP00000004158	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	Notch receptor 1.	0.464