(22 nodes) Chromo/chromo shadow domain network (Ailuropoda melanoleuca)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SUV39H2	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (409 aa)
	CDYL	Chromodomain Y like. (543 aa)
	SMARCC1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1. (1041 aa)
	CHD4	Uncharacterized protein. (1929 aa)
	CHD1	Chromodomain helicase DNA binding protein 1. (1780 aa)
	CHD3-2	Uncharacterized protein. (561 aa)
	KAT5	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa)
	MPHOSPH8	M-phase phosphoprotein 8. (802 aa)
	LOC100465822	Uncharacterized protein. (183 aa)
	CBX5	Chromobox 5. (190 aa)
	ARID4A	AT-rich interaction domain 4A. (1277 aa)
	CHD3	Chromodomain helicase DNA binding protein 3. (1364 aa)
	SMARCC2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2. (1213 aa)
	CBX1	Chromobox 1. (189 aa)
	CHD7	Chromodomain helicase DNA binding protein 7. (2995 aa)
	CBX3	Chromobox 3. (188 aa)
	CHD8	Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2586 aa)
	KAT8	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (433 aa)
	CHD6	Chromodomain helicase DNA binding protein 6. (2717 aa)
	CHD5	Chromodomain helicase DNA binding protein 5. (1922 aa)
	CHD2	Uncharacterized protein. (1152 aa)
	SUV39H1	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (420 aa)

Your Current Organism:

Ailuropoda melanoleuca

NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARID4A	CHD1	ENSAMEP00000002682	ENSAMEP00000015504	AT-rich interaction domain 4A.	Chromodomain helicase DNA binding protein 1.	0.550
ARID4A	CHD2	ENSAMEP00000002682	ENSAMEP00000011362	AT-rich interaction domain 4A.	Uncharacterized protein.	0.558
ARID4A	CHD3	ENSAMEP00000002682	ENSAMEP00000003191	AT-rich interaction domain 4A.	Chromodomain helicase DNA binding protein 3.	0.658
ARID4A	CHD3-2	ENSAMEP00000002682	ENSAMEP00000017970	AT-rich interaction domain 4A.	Uncharacterized protein.	0.658
ARID4A	CHD4	ENSAMEP00000002682	ENSAMEP00000015028	AT-rich interaction domain 4A.	Uncharacterized protein.	0.658
ARID4A	CHD5	ENSAMEP00000002682	ENSAMEP00000010459	AT-rich interaction domain 4A.	Chromodomain helicase DNA binding protein 5.	0.658
ARID4A	CHD6	ENSAMEP00000002682	ENSAMEP00000009988	AT-rich interaction domain 4A.	Chromodomain helicase DNA binding protein 6.	0.546
ARID4A	CHD7	ENSAMEP00000002682	ENSAMEP00000006116	AT-rich interaction domain 4A.	Chromodomain helicase DNA binding protein 7.	0.546
ARID4A	CHD8	ENSAMEP00000002682	ENSAMEP00000006721	AT-rich interaction domain 4A.	Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...]	0.546
ARID4A	KAT5	ENSAMEP00000002682	ENSAMEP00000018343	AT-rich interaction domain 4A.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.495
ARID4A	KAT8	ENSAMEP00000002682	ENSAMEP00000007621	AT-rich interaction domain 4A.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.495
ARID4A	SMARCC1	ENSAMEP00000002682	ENSAMEP00000013802	AT-rich interaction domain 4A.	SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1.	0.704
ARID4A	SMARCC2	ENSAMEP00000002682	ENSAMEP00000003794	AT-rich interaction domain 4A.	SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2.	0.704
CBX1	CBX5	ENSAMEP00000005159	ENSAMEP00000000740	Chromobox 1.	Chromobox 5.	0.514
CBX1	CHD4	ENSAMEP00000005159	ENSAMEP00000015028	Chromobox 1.	Uncharacterized protein.	0.519
CBX1	LOC100465822	ENSAMEP00000005159	ENSAMEP00000020568	Chromobox 1.	Uncharacterized protein.	0.588
CBX1	SUV39H1	ENSAMEP00000005159	ENSAMEP00000013260	Chromobox 1.	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.	0.612
CBX1	SUV39H2	ENSAMEP00000005159	ENSAMEP00000012132	Chromobox 1.	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.	0.612
CBX3	SUV39H1	ENSAMEP00000006299	ENSAMEP00000013260	Chromobox 3.	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.	0.612
CBX3	SUV39H2	ENSAMEP00000006299	ENSAMEP00000012132	Chromobox 3.	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.	0.612