(129 nodes) PDZ superfamily network (Ailuropoda melanoleuca)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PDZD4	PDZ domain containing 4. (758 aa)
	PDZD3	PDZ domain containing 3. (504 aa)
	NLRX1	NLR family member X1. (976 aa)
	GRIP1	Glutamate receptor interacting protein 1. (1127 aa)
	SDCBP2	Syndecan binding protein 2. (292 aa)
	SNX27	Sorting nexin 27. (461 aa)
	GORASP1	Golgi reassembly stacking protein 1. (445 aa)
	GRASP	General receptor for phosphoinositides 1 associated scaffold protein. (260 aa)
	MPDZ	Multiple PDZ domain crumbs cell polarity complex component. (2063 aa)
	DEPTOR	DEP domain containing MTOR interacting protein. (409 aa)
	RAPGEF2	Rap guanine nucleotide exchange factor 2. (1523 aa)
	INTU	Inturned planar cell polarity protein. (942 aa)
	SIPA1L2	Signal induced proliferation associated 1 like 2. (1719 aa)
	FRMPD3	FERM and PDZ domain containing 3. (1751 aa)
	MPP1	Membrane palmitoylated protein 1. (433 aa)
	G1L819_AILME	PDZ domain-containing protein. (107 aa)
	PARD3B	Uncharacterized protein. (639 aa)
	MAST4	Microtubule associated serine/threonine kinase family member 4. (2492 aa)
	PDLIM2	Uncharacterized protein. (356 aa)
	TJP1	Tight junction protein 1; Belongs to the MAGUK family. (1765 aa)
	USH1C	USH1 protein network component harmonin. (908 aa)
	MAGI3	Membrane associated guanylate kinase, WW and PDZ domain containing 3. (1479 aa)
	PTPN13	Protein tyrosine phosphatase non-receptor type 13. (2487 aa)
	DLG1	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (766 aa)
	PDZD9	PDZ domain containing 9. (264 aa)
	MYO18A	Myosin XVIIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2054 aa)
	SHROOM2	Shroom family member 2. (1409 aa)
	FRMPD1	FERM and PDZ domain containing 1. (1579 aa)
	PDLIM3	PDZ and LIM domain 3. (364 aa)
	G1LFE2_AILME	Uncharacterized protein. (328 aa)
	GOPC	PDZ domain-containing protein. (465 aa)
	G1LGE8_AILME	Uncharacterized protein. (1320 aa)
	GIPC3-2	Uncharacterized protein. (588 aa)
	TJP3	Tight junction protein 3; Belongs to the MAGUK family. (916 aa)
	APBA3	Amyloid beta precursor protein binding family A member 3. (578 aa)
	PDLIM5	PDZ and LIM domain 5. (514 aa)
	SIPA1L1	Signal induced proliferation associated 1 like 1. (1561 aa)
	PDZD2	PDZ domain containing 2. (2824 aa)
	IL16	Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. (1331 aa)
	MPP6	Membrane palmitoylated protein 6; Belongs to the MAGUK family. (541 aa)
	SDCBP	Syndecan binding protein. (298 aa)
	SCRIB	Scribble planar cell polarity protein. (1601 aa)
	RADIL	Rap associating with DIL domain. (1027 aa)
	ARHGAP21	Rho GTPase activating protein 21. (1957 aa)
	G1LJG7_AILME	PDZ domain-containing protein. (621 aa)
	CASK	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (926 aa)
	TJP2	Uncharacterized protein; Belongs to the MAGUK family. (1233 aa)
	APBA1	Amyloid beta precursor protein binding family A member 1. (838 aa)
	LIMK2	LIM domain kinase 2. (617 aa)
	GIPC2	GIPC PDZ domain containing family member 2. (316 aa)
	SHANK2	SH3 and multiple ankyrin repeat domains 2. (1822 aa)
	CNKSR3	Uncharacterized protein. (557 aa)
	G1LMC6_AILME	Uncharacterized protein. (743 aa)
	RIMS1	Regulating synaptic membrane exocytosis 1. (1621 aa)
	LNX1	Ligand of numb-protein X 1. (732 aa)
	ARHGEF12	Rho guanine nucleotide exchange factor 12. (1546 aa)
	MPP7	Membrane palmitoylated protein 7; Belongs to the MAGUK family. (576 aa)
	MPP5	Membrane palmitoylated protein 5. (675 aa)
	PANDA_020572	PDZ domain-containing protein. (52 aa)
	PTPN4	Protein tyrosine phosphatase non-receptor type 4. (926 aa)
	DLG2	Uncharacterized protein. (452 aa)
	GORASP2	Golgi reassembly stacking protein 2. (432 aa)
	PDZD11	PDZ domain-containing protein. (140 aa)
	TAX1BP3	Tax1-binding protein 3; May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. (124 aa)
	GRIP2	Glutamate receptor interacting protein 2. (1047 aa)
	DLG3	Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family. (939 aa)
	AFDN	Afadin, adherens junction formation factor. (1801 aa)
	SNTG2	Syntrophin gamma 2. (483 aa)
	SNTG1	Syntrophin gamma 1. (430 aa)
	CARD11	Caspase recruitment domain family member 11. (1150 aa)
	LDB3	LIM domain binding 3. (723 aa)
	FRMPD4	FERM and PDZ domain containing 4. (1753 aa)
	PDZRN4	PDZ domain containing ring finger 4. (757 aa)
	PICK1	Protein interacting with PRKCA 1. (417 aa)
	PARD6G	Par-6 family cell polarity regulator gamma. (271 aa)
	RHPN1	Rhophilin Rho GTPase binding protein 1. (658 aa)
	SIPA1L3	Signal induced proliferation associated 1 like 3. (1713 aa)
	MAST3	Microtubule associated serine/threonine kinase 3. (1302 aa)
	ERBIN	Erbb2 interacting protein. (1460 aa)
	LRRC7	Leucine rich repeat containing 7. (1537 aa)
	LMO7	LIM domain 7. (1549 aa)
	PATJ	PATJ crumbs cell polarity complex component. (1841 aa)
	PANDA_014189	Uncharacterized protein. (71 aa)
	PPP1R9B	Protein phosphatase 1 regulatory subunit 9B. (683 aa)
	MAGIX	MAGI family member, X-linked. (266 aa)
	MAST1	Microtubule associated serine/threonine kinase 1. (1563 aa)
	WHRN	Whirlin. (887 aa)
	NOS1	Nitric oxide synthase 1. (1463 aa)
	TIAM2	T cell lymphoma invasion and metastasis 2. (1562 aa)
	MAGI2	Membrane associated guanylate kinase, WW and PDZ domain containing 2. (1193 aa)
	RGS3	Regulator of G protein signaling 3. (1118 aa)
	SNTA1	Syntrophin alpha 1. (437 aa)
	LIN7A	Lin-7 homolog A, crumbs cell polarity complex component. (233 aa)
	MPP4	Membrane palmitoylated protein 4; Belongs to the MAGUK family. (636 aa)
	GIPC1	GIPC PDZ domain containing family member 1. (332 aa)
	MAST2	Microtubule associated serine/threonine kinase 2. (1779 aa)
	DVL1	Dishevelled segment polarity protein 1. (700 aa)
	PDZD8	PDZ domain containing 8. (1090 aa)
	CYTIP	Cytohesin 1 interacting protein. (353 aa)
	LIN7B	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (195 aa)
	LIN7C	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (197 aa)
	PSMD9	PDZ domain-containing protein. (223 aa)
	MAGI1	Membrane associated guanylate kinase, WW and PDZ domain containing 1. (1366 aa)
	STXBP4	Syntaxin binding protein 4. (557 aa)
	RGS12	Regulator of G protein signaling 12. (1296 aa)
	PREX2	Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2. (1605 aa)
	HTRA3	HtrA serine peptidase 3. (458 aa)
	TIAM1	Uncharacterized protein. (829 aa)
	APBA2	Uncharacterized protein. (394 aa)
	LIMK1	LIM domain kinase 1. (632 aa)
	HTRA4	HtrA serine peptidase 4. (377 aa)
	RHPN2	Rhophilin Rho GTPase binding protein 2. (686 aa)
	PARD3	Uncharacterized protein. (843 aa)
	PDLIM1	PDZ and LIM domain 1. (329 aa)
	DLG4	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (761 aa)
	MBTPS2	Membrane bound transcription factor peptidase, site 2. (528 aa)
	CNKSR2	Connector enhancer of kinase suppressor of Ras 2. (1033 aa)
	DVL2	Dishevelled segment polarity protein 2. (731 aa)
	HTRA2	HtrA serine peptidase 2. (458 aa)
	PARD6A	Par-6 family cell polarity regulator alpha. (346 aa)
	PDZK1	PDZ domain containing 1. (528 aa)
	PDZD7	Uncharacterized protein. (520 aa)
	PDLIM4	PDZ and LIM domain 4. (366 aa)
	SLC9A3R2	SLC9A3 regulator 2. (266 aa)
	RAPGEF6	Uncharacterized protein. (1615 aa)
	PTPN3	Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (914 aa)
	PDLIM7	PDZ and LIM domain 7. (718 aa)
	MPP3	Membrane palmitoylated protein 3; Belongs to the MAGUK family. (602 aa)
	MPP2	Membrane palmitoylated protein 2; Belongs to the MAGUK family. (538 aa)

Your Current Organism:

Ailuropoda melanoleuca

NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFDN	ERBIN	ENSAMEP00000009962	ENSAMEP00000011904	Afadin, adherens junction formation factor.	Erbb2 interacting protein.	0.467
AFDN	G1L819_AILME	ENSAMEP00000009962	ENSAMEP00000003035	Afadin, adherens junction formation factor.	PDZ domain-containing protein.	0.436
AFDN	LMO7	ENSAMEP00000009962	ENSAMEP00000012072	Afadin, adherens junction formation factor.	LIM domain 7.	0.949
AFDN	PDZD11	ENSAMEP00000009962	ENSAMEP00000009668	Afadin, adherens junction formation factor.	PDZ domain-containing protein.	0.436
AFDN	RAPGEF2	ENSAMEP00000009962	ENSAMEP00000002639	Afadin, adherens junction formation factor.	Rap guanine nucleotide exchange factor 2.	0.527
AFDN	TJP1	ENSAMEP00000009962	ENSAMEP00000003346	Afadin, adherens junction formation factor.	Tight junction protein 1; Belongs to the MAGUK family.	0.960
AFDN	TJP2	ENSAMEP00000009962	ENSAMEP00000007343	Afadin, adherens junction formation factor.	Uncharacterized protein; Belongs to the MAGUK family.	0.961
AFDN	TJP3	ENSAMEP00000009962	ENSAMEP00000006189	Afadin, adherens junction formation factor.	Tight junction protein 3; Belongs to the MAGUK family.	0.561
APBA1	CASK	ENSAMEP00000007373	ENSAMEP00000007132	Amyloid beta precursor protein binding family A member 1.	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family.	0.989
APBA1	G1LGE8_AILME	ENSAMEP00000007373	ENSAMEP00000005987	Amyloid beta precursor protein binding family A member 1.	Uncharacterized protein.	0.604
APBA1	LIN7A	ENSAMEP00000007373	ENSAMEP00000013887	Amyloid beta precursor protein binding family A member 1.	Lin-7 homolog A, crumbs cell polarity complex component.	0.757
APBA1	LIN7B	ENSAMEP00000007373	ENSAMEP00000015241	Amyloid beta precursor protein binding family A member 1.	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family.	0.676
APBA1	LIN7C	ENSAMEP00000007373	ENSAMEP00000015317	Amyloid beta precursor protein binding family A member 1.	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family.	0.676
APBA1	MAGI3	ENSAMEP00000007373	ENSAMEP00000003578	Amyloid beta precursor protein binding family A member 1.	Membrane associated guanylate kinase, WW and PDZ domain containing 3.	0.434
APBA1	MPP1	ENSAMEP00000007373	ENSAMEP00000002977	Amyloid beta precursor protein binding family A member 1.	Membrane palmitoylated protein 1.	0.708
APBA1	MPP2	ENSAMEP00000007373	ENSAMEP00000019354	Amyloid beta precursor protein binding family A member 1.	Membrane palmitoylated protein 2; Belongs to the MAGUK family.	0.610
APBA1	MPP3	ENSAMEP00000007373	ENSAMEP00000019350	Amyloid beta precursor protein binding family A member 1.	Membrane palmitoylated protein 3; Belongs to the MAGUK family.	0.444
APBA1	MPP4	ENSAMEP00000007373	ENSAMEP00000014133	Amyloid beta precursor protein binding family A member 1.	Membrane palmitoylated protein 4; Belongs to the MAGUK family.	0.444
APBA1	MPP5	ENSAMEP00000007373	ENSAMEP00000008724	Amyloid beta precursor protein binding family A member 1.	Membrane palmitoylated protein 5.	0.452
APBA1	MPP6	ENSAMEP00000007373	ENSAMEP00000006500	Amyloid beta precursor protein binding family A member 1.	Membrane palmitoylated protein 6; Belongs to the MAGUK family.	0.610