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| | MED14 | Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1433 aa) |
| | GTF2F1 | Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (457 aa) |
| | PAX6 | Paired box 6. (439 aa) |
| | NR2F1 | Nuclear receptor subfamily 2 group F member 1. (406 aa) |
| | MED10 | Mediator of RNA polymerase II transcription subunit 10; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (94 aa) |
| | SMAD7 | Mothers against decapentaplegic homolog. (427 aa) |
| | RXRG | Retinoid X receptor gamma. (467 aa) |
| | EBF1 | EBF transcription factor 1. (591 aa) |
| | CHD8 | Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2586 aa) |
| | STAT3 | Signal transducer and activator of transcription. (771 aa) |
| | ARNT2 | Aryl hydrocarbon receptor nuclear translocator 2. (717 aa) |
| | NCOA2 | Nuclear receptor coactivator. (1464 aa) |
| | STAT5A | Signal transducer and activator of transcription. (794 aa) |
| | STAT5B | Signal transducer and activator of transcription. (783 aa) |
| | EPAS1 | Endothelial PAS domain protein 1. (865 aa) |
| | NFE2L3 | Nuclear factor, erythroid 2 like 3. (634 aa) |
| | KAT2A | Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (836 aa) |
| | HAVCR2 | Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. (469 aa) |
| | HDAC8 | Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (377 aa) |
| | RFX6 | DNA-binding protein RFX6; Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin. Not required for pancreatic PP (polypeptide- producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by [...] (928 aa) |
| | TBX22 | T-box transcription factor 22. (525 aa) |
| | CREB5 | Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa) |
| | NFIC | Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (506 aa) |
| | SIM2 | SIM bHLH transcription factor 2. (537 aa) |
| | ZSCAN10 | Zinc finger and SCAN domain containing 10. (775 aa) |
| | SATB2 | DNA-binding protein SATB. (757 aa) |
| | RUNX1 | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (426 aa) |
| | AGO2 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (858 aa) |
| | TEAD4 | TEA domain transcription factor 4. (477 aa) |
| | ZSCAN4 | Zinc finger and SCAN domain-containing protein 4; Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells (By similarity). (337 aa) |
| | NFE2L1 | Nuclear factor, erythroid 2 like 1. (796 aa) |
| | PPARG | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa) |
| | SUPT6H | Transcription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. (1726 aa) |
| | EPC2 | Enhancer of polycomb homolog. (807 aa) |
| | TFDP1 | Transcription factor. (407 aa) |
| | TBX21 | T-box transcription factor 21. (439 aa) |
| | PAX4 | Paired box 4. (346 aa) |
| | STAT6 | Signal transducer and activator of transcription. (844 aa) |
| | NR4A3 | Nuclear receptor subfamily 4 group A member 3. (560 aa) |
| | NR2C2 | Nuclear receptor subfamily 2 group C member 2. (596 aa) |
| | TBX19 | T-box transcription factor 19. (444 aa) |
| | ESR2 | Estrogen receptor 2. (552 aa) |
| | MED1 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa) |
| | HNF4A | Hepatocyte nuclear factor 4 alpha. (474 aa) |
| | NEUROD2 | Neurogenic differentiation factor. (312 aa) |
| | STAT2 | Signal transducer and activator of transcription. (859 aa) |
| | MED4 | Mediator of RNA polymerase II transcription subunit 4; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (270 aa) |
| | EGR2 | Early growth response 2. (471 aa) |
| | ARID5B | AT-rich interaction domain 5B. (1188 aa) |
| | BACH2 | BTB domain and CNC homolog 2; Belongs to the bZIP family. (841 aa) |
| | NR2F2 | Nuclear receptor subfamily 2 group F member 2. (385 aa) |
| | PPARA | Peroxisome proliferator activated receptor alpha. (472 aa) |
| | MEF2A | Myocyte enhancer factor 2A. (530 aa) |
| | EBF3 | EBF transcription factor 3. (547 aa) |
| | SMAD3 | Mothers against decapentaplegic homolog. (425 aa) |
| | LOC100465141 | General transcription factor IIH subunit. (395 aa) |
| | HIF1A | Hypoxia inducible factor 1 subunit alpha. (823 aa) |
| | ARID3A | AT-rich interaction domain 3A. (449 aa) |
| | EGR3 | Early growth response 3. (382 aa) |
| | MED16 | Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (828 aa) |
| | SMAD4 | Mothers against decapentaplegic homolog. (552 aa) |
| | PAX9 | Paired box 9. (342 aa) |
| | NCOA1 | Nuclear receptor coactivator. (1505 aa) |
| | ARID4A | AT-rich interaction domain 4A. (1277 aa) |
| | ACTR8 | Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize (By similarity); Belongs to the actin family. ARP8 subfamily. (624 aa) |
| | E2F5 | E2F transcription factor 5. (372 aa) |
| | ARNTL | Aryl hydrocarbon receptor nuclear translocator like. (658 aa) |
| | MED9 | Mediator of RNA polymerase II transcription subunit 9; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (142 aa) |
| | TEAD1 | TEA domain transcription factor 1. (384 aa) |
| | NR2C1 | Nuclear receptor subfamily 2 group C member 1. (607 aa) |
| | NR3C2 | Nuclear receptor subfamily 3 group C member 2. (978 aa) |
| | ZNF445 | Zinc finger protein 445. (955 aa) |
| | NFIB | Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa) |
| | ZNF500 | Uncharacterized protein. (362 aa) |
| | NR4A1 | Nuclear receptor subfamily 4 group A member 1. (589 aa) |
| | RXRB | Retinoid X receptor beta. (536 aa) |
| | TBX20 | T-box transcription factor 20. (451 aa) |
| | MED8 | Mediator of RNA polymerase II transcription subunit 8; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (269 aa) |
| | ESRRG | Estrogen related receptor gamma. (463 aa) |
| | ARNT | Aryl hydrocarbon receptor nuclear translocator. (789 aa) |
| | G1L2T7_AILME | Uncharacterized protein. (408 aa) |
| | TBX5 | T-box transcription factor 5. (517 aa) |
| | TBX3 | T-box transcription factor 3. (717 aa) |
| | TBX10 | T-box transcription factor 10. (383 aa) |
| | LPXN | Leupaxin; Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN). (391 aa) |
| | TP63 | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa) |
| | NFE2 | Nuclear factor, erythroid 2. (373 aa) |
| | RARB | Retinoic acid receptor beta. (407 aa) |
| | PPARD | Peroxisome proliferator activated receptor delta. (441 aa) |
| | TEAD3 | Transcriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (513 aa) |
| | NR1D2 | Nuclear receptor subfamily 1 group D member 2. (571 aa) |
| | ZNF397 | Zinc finger protein 397. (534 aa) |
| | ZSCAN30 | Zinc finger and SCAN domain containing 30. (492 aa) |
| | ZNF24 | Zinc finger protein 24. (368 aa) |
| | RORC | RAR related orphan receptor C. (524 aa) |
| | JARID2 | Jumonji and AT-rich interaction domain containing 2. (1248 aa) |
| | EBF2 | EBF transcription factor 2. (575 aa) |
| | JUN | Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (301 aa) |
| | ELP3 | Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. (547 aa) |
| | ELOF1 | Transcription elongation factor 1 homolog; Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. Belongs to the ELOF1 family. (83 aa) |
| | HNF4G | Hepatocyte nuclear factor 4 gamma. (474 aa) |
| | MAFG | MAF bZIP transcription factor G. (160 aa) |
| | PGR | Progesterone receptor. (925 aa) |
| | HEY1 | Hes related family bHLH transcription factor with YRPW motif 1. (308 aa) |
| | PAX2 | Paired box 2. (506 aa) |
| | E2F3 | E2F transcription factor 3. (335 aa) |
| | SMAD5 | Mothers against decapentaplegic homolog. (465 aa) |
| | E2F8 | E2F transcription factor 8. (863 aa) |
| | ESRRA | Estrogen related receptor alpha. (424 aa) |
| | THRB | Thyroid hormone receptor beta. (476 aa) |
| | RIOX1 | Bifunctional lysine-specific demethylase and histidyl-hydroxylase; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. (621 aa) |
| | HDAC5 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1111 aa) |
| | ATXN7L3 | Ataxin-7-like protein 3; Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and EN [...] (354 aa) |
| | ESRRB | Estrogen related receptor beta. (501 aa) |
| | CLOCK | Clock circadian regulator. (848 aa) |
| | MECP2 | Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (483 aa) |
| | PANDA_019072 | Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (144 aa) |
| | E2F4 | E2F transcription factor 4. (430 aa) |
| | G1MFF5_AILME | Uncharacterized protein. (509 aa) |
| | PAX7 | Paired box 7. (510 aa) |
| | NPAS4 | Neuronal PAS domain protein 4. (800 aa) |
| | ELP1 | Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. Belongs to the ELP1/IKA1 family. (1346 aa) |
| | ZNF496 | Zinc finger protein 496. (567 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa) |
| | ETS2 | Protein C-ets-2; Transcription factor; Belongs to the ETS family. (469 aa) |
| | SMAD1 | Mothers against decapentaplegic homolog. (465 aa) |
| | MGA | MAX dimerization protein MGA. (3114 aa) |
| | HES4 | Hes family bHLH transcription factor 4. (219 aa) |
| | EGR1 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (541 aa) |
| | NRL | Neural retina leucine zipper. (242 aa) |
| | PRDM12 | PR domain zinc finger protein 12; Involved in the positive regulation of histone H3-K9 dimethylation; Belongs to the class V-like SAM-binding methyltransferase superfamily. (330 aa) |
| | PRDM4 | PR domain zinc finger protein 4; May function as a transcription factor involved in cell differentiation. (802 aa) |
| | TAF1 | Transcription initiation factor TFIID subunit. (1905 aa) |
| | MED11 | Mediator of RNA polymerase II transcription subunit 11; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (130 aa) |
| | BHLHE40 | Basic helix-loop-helix family member e40. (416 aa) |
| | EYA4 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (645 aa) |
| | TBX18 | T-box transcription factor 18. (612 aa) |
| | HES1 | Hes family bHLH transcription factor 1. (216 aa) |
| | RORB | RAR related orphan receptor B. (471 aa) |
| | CUX1 | Homeobox protein cut-like. (1302 aa) |
| | NR1I3 | Nuclear receptor subfamily 1 group I member 3. (419 aa) |
| | MAFK | MAF bZIP transcription factor K. (110 aa) |
| | TBX6 | T-box transcription factor 6. (431 aa) |
| | NR1H4 | Nuclear receptor subfamily 1 group H member 4. (486 aa) |
| | RUVBL1 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa) |
| | KDM1A | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (818 aa) |
| | SIM1 | SIM bHLH transcription factor 1. (766 aa) |
| | MEF2D | Myocyte enhancer factor 2D. (516 aa) |
| | MED19 | Mediator of RNA polymerase II transcription subunit 19; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (245 aa) |
| | ARID3C | AT-rich interaction domain 3C. (411 aa) |
| | RUVBL2 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (467 aa) |
| | SMAD9 | Mothers against decapentaplegic homolog. (478 aa) |
| | SSRP1 | FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (709 aa) |
| | TEAD2 | TEA domain transcription factor 2. (445 aa) |
| | STAT1 | Signal transducer and activator of transcription. (1169 aa) |
| | ZSCAN2 | Zinc finger and SCAN domain containing 2. (613 aa) |
| | CUX2 | Homeobox protein cut-like. (1474 aa) |
| | VDR | Vitamin D receptor. (445 aa) |
| | RIOX2 | Bifunctional lysine-specific demethylase and histidyl-hydroxylase; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. (464 aa) |
| | SMARCB1 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (385 aa) |
| | EYA2 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (440 aa) |
| | SOX11 | Transcription factor SOX. (380 aa) |
| | MEF2C | Myocyte enhancer factor 2C. (473 aa) |
| | NCOA3 | Nuclear receptor coactivator. (1414 aa) |
| | TADA2A | Transcriptional adapter. (443 aa) |
| | NR1H2 | Nuclear receptor subfamily 1 group H member 2. (496 aa) |
| | GTF2H4 | General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (463 aa) |
| | KMT2A | Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (3888 aa) |
| | MED20 | Mediator of RNA polymerase II transcription subunit 20; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (212 aa) |
| | GTF2F2 | General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (249 aa) |
| | MED17 | Mediator of RNA polymerase II transcription subunit 17; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (653 aa) |
| | G1M2K3_AILME | E2F_TDP domain-containing protein. (120 aa) |
| | SMAD2 | Mothers against decapentaplegic homolog. (467 aa) |
| | EOMES | Eomesodermin. (498 aa) |
| | NR5A2 | Nuclear receptor subfamily 5 group A member 2. (541 aa) |
| | G1M1W0_AILME | Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. (494 aa) |
| | PAX1 | Paired box 1. (451 aa) |
| | NFIX | Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (528 aa) |
| | TFDP2 | Transcription factor. (446 aa) |
| | MED13L | Mediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (2194 aa) |
| | SRF | Serum response factor. (444 aa) |
| | TBR1 | T-box brain transcription factor 1. (627 aa) |
| | ATF2 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa) |
| | RARG | Retinoic acid receptor gamma. (464 aa) |
| | NFE2L2 | Nuclear factor, erythroid 2 like 2. (610 aa) |
| | G1LZL0_AILME | Uncharacterized protein. (322 aa) |
| | NFIA | Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (527 aa) |
| | MEF2B | Myocyte enhancer factor 2B. (358 aa) |
| | MED21 | Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (173 aa) |
| | ARNTL2 | Aryl hydrocarbon receptor nuclear translocator like 2. (625 aa) |
| | HEYL | Hes related family bHLH transcription factor with YRPW motif like. (328 aa) |
| | TBX1 | Uncharacterized protein. (205 aa) |
| | HIRA | Protein HIRA; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. (1019 aa) |
| | HDAC4 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1087 aa) |
| | MED18 | Mediator of RNA polymerase II transcription subunit 18; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (215 aa) |
| | ZSCAN21 | Zinc finger and SCAN domain containing 21. (464 aa) |
| | EBF4 | IPT/TIG domain-containing protein. (385 aa) |
| | NR6A1 | Nuclear receptor subfamily 6 group A member 1. (447 aa) |
| | EYA3 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (573 aa) |
| | G1LXK0_AILME | Uncharacterized protein. (88 aa) |
| | NR5A1 | Nuclear receptor subfamily 5 group A member 1. (465 aa) |
| | RXRA | Retinoid X receptor alpha. (469 aa) |
| | MED15 | Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (857 aa) |
| | JUND | JunD proto-oncogene, AP-1 transcription factor subunit. (298 aa) |
| | ESR1 | Estrogen receptor 1. (449 aa) |
| | SETD7 | Histone-lysine N-methyltransferase SETD7; Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes. (373 aa) |
| | NR0B2 | Nuclear receptor subfamily 0 group B member 2. (267 aa) |
| | EYA1 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (425 aa) |
| | ARID1A | AT-rich interaction domain 1A. (1905 aa) |
| | PAX8 | Paired box 8. (461 aa) |
| | ZNF174 | Zinc finger protein 174. (410 aa) |
| | AHR | Uncharacterized protein. (836 aa) |
| | MAFF | MAF bZIP transcription factor F. (170 aa) |
| | HDAC3 | Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa) |
| | G1LV86_AILME | Uncharacterized protein. (318 aa) |
| | NR2F6 | Nuclear receptor subfamily 2 group F member 6. (409 aa) |
| | EPC1 | Enhancer of polycomb homolog. (842 aa) |
| | MAF | BZIP domain-containing protein; Belongs to the bZIP family. (175 aa) |
| | NR3C1 | Nuclear receptor subfamily 3 group C member 1. (784 aa) |
| | PAX5 | Paired box 5. (391 aa) |
| | RUNX3 | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (381 aa) |
| | NR4A2 | Nuclear receptor subfamily 4 group A member 2. (598 aa) |
| | HES2 | Hes family bHLH transcription factor 2. (162 aa) |
| | ARID1B | AT-rich interaction domain 1B. (1777 aa) |
| | E2F2 | E2F transcription factor 2. (440 aa) |
| | HEY2 | Hes related family bHLH transcription factor with YRPW motif 2. (335 aa) |
| | ZSCAN5B | Uncharacterized protein. (360 aa) |
| | ZNF444 | Zinc finger protein 444. (300 aa) |
| | TBXT | T-box transcription factor T. (436 aa) |
| | TP73 | Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (639 aa) |
| | RUNX2 | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (477 aa) |
| | NR0B1 | Nuclear receptor subfamily 0 group B member 1. (474 aa) |
| | E2F1 | E2F transcription factor 1. (355 aa) |
| | ARID5A | AT-rich interaction domain 5A. (597 aa) |
| | NR2E3 | Nuclear receptor subfamily 2 group E member 3. (412 aa) |
| | TBX2 | T-box transcription factor 2. (621 aa) |
| | ARID4B | AT-rich interaction domain 4B. (1311 aa) |
| | TBX4 | T-box transcription factor 4. (548 aa) |
| | MED13 | Mediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (2172 aa) |
| | HELT | Helt bHLH transcription factor. (319 aa) |
| | HIF3A | Hypoxia inducible factor 3 subunit alpha. (671 aa) |
| | AR | Androgen receptor. (885 aa) |
| | HDAC9 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1068 aa) |
| | AHRR | Uncharacterized protein. (718 aa) |
| | BACH1 | BTB domain and CNC homolog 1. (715 aa) |
| | IRF2 | Interferon regulatory factor. (349 aa) |
| | USP16 | Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. (824 aa) |
| | TBX15 | T-box transcription factor 15. (602 aa) |
| | NR2E1 | Nuclear receptor subfamily 2 group E member 1. (405 aa) |
| | RORA | RAR related orphan receptor A. (468 aa) |
| | MED6 | Mediator of RNA polymerase II transcription subunit 6; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (253 aa) |
| | RARA | Retinoic acid receptor alpha. (461 aa) |
| | PRMT7 | Protein arginine N-methyltransferase; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being r [...] (696 aa) |
| | NR1D1 | Nuclear receptor subfamily 1 group D member 1. (613 aa) |
| | THRA | Thyroid hormone receptor alpha. (478 aa) |
| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (485 aa) |
| | PAX3 | Paired box 3. (505 aa) |
| | ZNF446 | Zinc finger protein 446. (520 aa) |
| | ONECUT1 | One cut domain family member. (460 aa) |
| | ZSCAN22 | Zinc finger and SCAN domain containing 22. (490 aa) |
| | ZSCAN1 | Zinc finger and SCAN domain containing 1. (413 aa) |
| | NR1H3 | Nuclear receptor subfamily 1 group H member 3. (447 aa) |
| | E2F7 | E2F transcription factor 7. (909 aa) |
| | ZSCAN20 | Zinc finger and SCAN domain containing 20. (876 aa) |
| | NR1I2 | Nuclear receptor subfamily 1 group I member 2. (442 aa) |
| | MED31 | Mediator of RNA polymerase II transcription subunit 31; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (131 aa) |
