(121 nodes) Signaling by NTRKs network (Ailuropoda melanoleuca)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RIT1	Ras like without CAAX 1. (234 aa)
	TRIB1	Tribbles pseudokinase 1. (297 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)
	FNDC3B	Fibronectin type III domain containing 3B. (1207 aa)
	SHC4	SHC adaptor protein 4. (630 aa)
	PTK6	Tyrosine-protein kinase. (442 aa)
	SRMS	Tyrosine-protein kinase. (494 aa)
	PPP2CB	Serine/threonine-protein phosphatase. (308 aa)
	RPS6KA5	Ribosomal protein S6 kinase. (811 aa)
	DUSP6	Dual specificity phosphatase 6. (381 aa)
	ASCL2	Achaete-scute family bHLH transcription factor 2. (219 aa)
	MAP2K2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
	ATF1	Activating transcription factor 1. (283 aa)
	MAPK11	Mitogen-activated protein kinase. (371 aa)
	SHC2	Uncharacterized protein. (486 aa)
	EGR3	Early growth response 3. (382 aa)
	PCSK6	Proprotein convertase subtilisin/kexin type 6; Belongs to the peptidase S8 family. (874 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (733 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	SHC3	SHC adaptor protein 3. (492 aa)
	PCSK4	Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family. (687 aa)
	PCSK5	Proprotein convertase subtilisin/kexin type 5. (1682 aa)
	FNDC3A	Fibronectin type III domain containing 3A. (1198 aa)
	EGR2	Early growth response 2. (471 aa)
	PTPRO	Protein tyrosine phosphatase receptor type O. (1206 aa)
	NTRK2	Tyrosine-protein kinase receptor. (838 aa)
	YWHAB	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
	IRS1	Insulin receptor substrate 1. (1107 aa)
	PPP2R1B	Protein phosphatase 2 scaffold subunit Abeta. (696 aa)
	RALGDS	Uncharacterized protein. (801 aa)
	NAB2	NGFI-A binding protein 2. (525 aa)
	MAPK7	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (807 aa)
	G1LDL4_AILME	Ras-GEF domain-containing protein. (587 aa)
	MAP2K5	Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
	G1LEP6_AILME	Ras-GEF domain-containing protein. (326 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1071 aa)
	RAP1A	RAP1A, member of RAS oncogene family. (184 aa)
	G1LHI2_AILME	BHLH domain-containing protein. (72 aa)
	DUSP4	Dual specificity phosphatase 4. (391 aa)
	AP2A2	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (937 aa)
	RELCH	RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1214 aa)
	PPP4R4	Protein phosphatase 4 regulatory subunit 4. (871 aa)
	ASCL1	Achaete-scute family bHLH transcription factor 1. (202 aa)
	MAPK15	Mitogen-activated protein kinase. (552 aa)
	RIT2	Ras like without CAAX 2. (217 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	PPP4R1	Protein phosphatase 4 regulatory subunit 1. (937 aa)
	G1LM52_AILME	Ras-GEF domain-containing protein. (336 aa)
	G1LM57_AILME	P/Homo B domain-containing protein. (742 aa)
	FNBP4	Formin binding protein 4. (1014 aa)
	CRK	CRK proto-oncogene, adaptor protein. (303 aa)
	ID2	Inhibitor of DNA binding 2. (134 aa)
	RALA	RAS like proto-oncogene A. (206 aa)
	KIDINS220	Kinase D interacting substrate 220. (1772 aa)
	AP2S1	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (146 aa)
	RALB	RAS like proto-oncogene B. (212 aa)
	CRKL	CRK like proto-oncogene, adaptor protein. (303 aa)
	MAPK1	Mitogen-activated protein kinase. (320 aa)
	DUSP7	Dual specificity phosphatase 7. (365 aa)
	GRB2	Growth factor receptor bound protein 2. (192 aa)
	RPS6KA2	Ribosomal protein S6 kinase. (741 aa)
	G1LS07_AILME	DHR-2 domain-containing protein; Belongs to the DOCK family. (716 aa)
	PLCG1	Phosphoinositide phospholipase C. (1294 aa)
	ID3	Inhibitor of DNA binding 3, HLH protein. (125 aa)
	CLTA	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (247 aa)
	DOCK3	Uncharacterized protein; Belongs to the DOCK family. (1205 aa)
	PPP2R1A	Protein phosphatase 2 scaffold subunit Aalpha. (589 aa)
	HRAS	HRas proto-oncogene, GTPase. (253 aa)
	RPS6KA1	Ribosomal protein S6 kinase. (767 aa)
	DNAL4	Dynein light chain. (105 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
	SH3GL2	SH3 domain containing GRB2 like 2, endophilin A1. (337 aa)
	IRS2	Insulin receptor substrate 2. (1005 aa)
	PIK3R2	Uncharacterized protein. (716 aa)
	JUND	JunD proto-oncogene, AP-1 transcription factor subunit. (298 aa)
	MAPKAPK3	MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (384 aa)
	SHC1	SHC adaptor protein 1. (587 aa)
	CLTC	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1675 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (507 aa)
	SRC	Tyrosine-protein kinase. (542 aa)
	FOSB	FosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
	NKPD1	Uncharacterized protein. (266 aa)
	ERAS	ES cell expressed Ras. (233 aa)
	SRF	Serum response factor. (444 aa)
	LYL1	LYL1 basic helix-loop-helix family member. (259 aa)
	G1M1Y8_AILME	WRNPLPNID domain-containing protein. (928 aa)
	PPP2R5D	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (619 aa)
	TRIB2	Tribbles pseudokinase 2. (343 aa)
	NTRK3	Ig-like domain-containing protein. (382 aa)
	ELK1	ETS transcription factor ELK1. (427 aa)
	VRK3	VRK serine/threonine kinase 3. (469 aa)
	AP2A1	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (976 aa)
	FURIN	P/Homo B domain-containing protein; Belongs to the peptidase S8 family. (793 aa)
	NAB1	NGFI-A binding protein 1. (490 aa)
	CHD4	Uncharacterized protein. (1929 aa)
	BDNF	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (323 aa)
	NTRK1	Tyrosine-protein kinase receptor. (725 aa)
	AP2B1	AP complex subunit beta. (951 aa)
	G1M8X5_AILME	PH domain-containing protein. (507 aa)
	CREB1	cAMP responsive element binding protein 1. (341 aa)
	MAPK3	Mitogen-activated protein kinase. (351 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (787 aa)
	EGR4	Early growth response 4. (483 aa)
	SGK1	Serum/glucocorticoid regulated kinase 1. (526 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
	RAPGEF1	Rap guanine nucleotide exchange factor 1. (1187 aa)
	EGR1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (541 aa)
	RPS6KA3	Ribosomal protein S6 kinase. (719 aa)
	FYN	Tyrosine-protein kinase. (537 aa)
	CSDE1	Cold shock domain containing E1. (813 aa)
	NRAS	NRAS proto-oncogene, GTPase. (193 aa)
	RRAD	GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (278 aa)
	AP2M1	MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family. (436 aa)
	MAPKAPK2	MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (408 aa)
	G1MGW8_AILME	Uncharacterized protein. (908 aa)
	PPP2CA	Serine/threonine-protein phosphatase. (309 aa)
	RPS6KA4	Non-specific serine/threonine protein kinase. (715 aa)
	DUSP3	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (153 aa)
	NGF	Nerve growth factor; Belongs to the NGF-beta family. (240 aa)
	NTF3	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (270 aa)
	G1MMB6_AILME	Uncharacterized protein. (57 aa)

Your Current Organism:

Ailuropoda melanoleuca

NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AP2A1	AP2A2	ENSAMEP00000014539	ENSAMEP00000006476	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.950
AP2A1	AP2B1	ENSAMEP00000014539	ENSAMEP00000015598	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	AP complex subunit beta.	0.990
AP2A1	AP2M1	ENSAMEP00000014539	ENSAMEP00000018237	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family.	0.999
AP2A1	AP2S1	ENSAMEP00000014539	ENSAMEP00000008837	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.996
AP2A1	CLTA	ENSAMEP00000014539	ENSAMEP00000010510	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.975
AP2A1	CLTC	ENSAMEP00000014539	ENSAMEP00000012157	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.979
AP2A1	DNAL4	ENSAMEP00000014539	ENSAMEP00000011334	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Dynein light chain.	0.427
AP2A1	GRB2	ENSAMEP00000014539	ENSAMEP00000009814	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Growth factor receptor bound protein 2.	0.576
AP2A1	MAPK7	ENSAMEP00000014539	ENSAMEP00000004739	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.423
AP2A1	NGF	ENSAMEP00000014539	ENSAMEP00000019842	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Nerve growth factor; Belongs to the NGF-beta family.	0.491
AP2A1	NTRK1	ENSAMEP00000014539	ENSAMEP00000015519	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Tyrosine-protein kinase receptor.	0.485
AP2A1	SH3GL2	ENSAMEP00000014539	ENSAMEP00000011396	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	SH3 domain containing GRB2 like 2, endophilin A1.	0.571
AP2A2	AP2A1	ENSAMEP00000006476	ENSAMEP00000014539	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.950
AP2A2	AP2B1	ENSAMEP00000006476	ENSAMEP00000015598	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	AP complex subunit beta.	0.998
AP2A2	AP2M1	ENSAMEP00000006476	ENSAMEP00000018237	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family.	0.999
AP2A2	AP2S1	ENSAMEP00000006476	ENSAMEP00000008837	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.993
AP2A2	CLTA	ENSAMEP00000006476	ENSAMEP00000010510	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.960
AP2A2	CLTC	ENSAMEP00000006476	ENSAMEP00000012157	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.967
AP2A2	GRB2	ENSAMEP00000006476	ENSAMEP00000009814	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Growth factor receptor bound protein 2.	0.525
AP2A2	MAPK1	ENSAMEP00000006476	ENSAMEP00000009359	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Mitogen-activated protein kinase.	0.492