(49 nodes) Low-density lipoprotein receptor domain class A network (Ailuropoda melanoleuca)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	G1L0X8_AILME	Uncharacterized protein. (669 aa)
	LRP5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1586 aa)
	LRP6	LDL receptor related protein 6. (1463 aa)
	TMPRSS3	Transmembrane serine protease 3; Belongs to the peptidase S1 family. (540 aa)
	ST14	Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Belongs to the peptidase S1 family. (830 aa)
	RXFP1	Relaxin family peptide receptor 1. (769 aa)
	SSPO	SCO-spondin. (5137 aa)
	CORIN	Corin, serine peptidase. (1021 aa)
	TMPRSS13	Transmembrane serine protease 13; Belongs to the peptidase S1 family. (534 aa)
	C8A	Complement C8 alpha chain. (589 aa)
	G1LD59_AILME	Uncharacterized protein; Belongs to the peptidase S1 family. (586 aa)
	LRP1	LDL receptor related protein 1. (4543 aa)
	NETO2	Neuropilin and tolloid like 2. (525 aa)
	CD320	CD320 molecule. (268 aa)
	ALK	ALK receptor tyrosine kinase. (1269 aa)
	TMPRSS9	Transmembrane serine protease 9; Belongs to the peptidase S1 family. (1043 aa)
	LRP12	LDL receptor related protein 12. (859 aa)
	G1LHI3_AILME	MAM domain-containing protein. (240 aa)
	C8B	Complement C8 beta chain. (491 aa)
	LRP4	LDL receptor related protein 4. (1888 aa)
	LRP10	LDL receptor related protein 10. (714 aa)
	MFRP	Uncharacterized protein. (585 aa)
	LRP3	LDL receptor related protein 3. (755 aa)
	SORL1	Sortilin related receptor 1. (2178 aa)
	RXFP2	Relaxin family peptide receptor 2. (754 aa)
	LRP8	LDL receptor related protein 8. (964 aa)
	LDLRAD1	Low density lipoprotein receptor class A domain containing 1. (188 aa)
	PRKCSH	Protein kinase C substrate 80K-H. (534 aa)
	TMPRSS2	Transmembrane serine protease 2; Belongs to the peptidase S1 family. (514 aa)
	LRP2	LDL receptor related protein 2. (4621 aa)
	LDLR	Low density lipoprotein receptor. (870 aa)
	DGCR2	DiGeorge syndrome critical region gene 2. (549 aa)
	TMPRSS15	Transmembrane serine protease 15; Belongs to the peptidase S1 family. (634 aa)
	VLDLR	Very low density lipoprotein receptor. (873 aa)
	LRP1B	LDL receptor related protein 1B. (4451 aa)
	G1M2W0_AILME	Uncharacterized protein. (351 aa)
	MAMDC4	MAM domain containing 4. (1221 aa)
	TMPRSS4	Transmembrane serine protease 4; Belongs to the peptidase S1 family. (445 aa)
	NETO1	Neuropilin and tolloid like 1. (533 aa)
	LDLRAD3	Low density lipoprotein receptor class A domain containing 3. (325 aa)
	LDLRAD2	Low density lipoprotein receptor class A domain containing 2. (266 aa)
	HSPG2	Heparan sulfate proteoglycan 2. (4396 aa)
	C6	Complement C6. (938 aa)
	C7	Complement C7. (843 aa)
	SPINT1	Serine peptidase inhibitor, Kunitz type 1. (533 aa)
	C9	Complement C9. (551 aa)
	LDLRAD4	Low density lipoprotein receptor class A domain containing 4. (306 aa)
	TMPRSS7	Transmembrane serine protease 7. (829 aa)
	PANDA_004055	Uncharacterized protein. (39 aa)

Your Current Organism:

Ailuropoda melanoleuca

NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C6	C7	ENSAMEP00000016133	ENSAMEP00000016257	Complement C6.	Complement C7.	0.997
C6	C8A	ENSAMEP00000016133	ENSAMEP00000004307	Complement C6.	Complement C8 alpha chain.	0.954
C6	C8B	ENSAMEP00000016133	ENSAMEP00000007401	Complement C6.	Complement C8 beta chain.	0.944
C6	C9	ENSAMEP00000016133	ENSAMEP00000018064	Complement C6.	Complement C9.	0.998
C7	C6	ENSAMEP00000016257	ENSAMEP00000016133	Complement C7.	Complement C6.	0.997
C7	C8A	ENSAMEP00000016257	ENSAMEP00000004307	Complement C7.	Complement C8 alpha chain.	0.955
C7	C8B	ENSAMEP00000016257	ENSAMEP00000007401	Complement C7.	Complement C8 beta chain.	0.944
C7	C9	ENSAMEP00000016257	ENSAMEP00000018064	Complement C7.	Complement C9.	0.996
C7	G1LD59_AILME	ENSAMEP00000016257	ENSAMEP00000004840	Complement C7.	Uncharacterized protein; Belongs to the peptidase S1 family.	0.520
C8A	C6	ENSAMEP00000004307	ENSAMEP00000016133	Complement C8 alpha chain.	Complement C6.	0.954
C8A	C7	ENSAMEP00000004307	ENSAMEP00000016257	Complement C8 alpha chain.	Complement C7.	0.955
C8A	C8B	ENSAMEP00000004307	ENSAMEP00000007401	Complement C8 alpha chain.	Complement C8 beta chain.	0.972
C8A	C9	ENSAMEP00000004307	ENSAMEP00000018064	Complement C8 alpha chain.	Complement C9.	0.961
C8B	C6	ENSAMEP00000007401	ENSAMEP00000016133	Complement C8 beta chain.	Complement C6.	0.944
C8B	C7	ENSAMEP00000007401	ENSAMEP00000016257	Complement C8 beta chain.	Complement C7.	0.944
C8B	C8A	ENSAMEP00000007401	ENSAMEP00000004307	Complement C8 beta chain.	Complement C8 alpha chain.	0.972
C8B	C9	ENSAMEP00000007401	ENSAMEP00000018064	Complement C8 beta chain.	Complement C9.	0.938
C9	C6	ENSAMEP00000018064	ENSAMEP00000016133	Complement C9.	Complement C6.	0.998
C9	C7	ENSAMEP00000018064	ENSAMEP00000016257	Complement C9.	Complement C7.	0.996
C9	C8A	ENSAMEP00000018064	ENSAMEP00000004307	Complement C9.	Complement C8 alpha chain.	0.961