STRINGSTRING
THBS3 THBS3 PTEN PTEN PPP1CA PPP1CA PIP5K1A PIP5K1A MAPK9 MAPK9 ITGA5 ITGA5 FLT4 FLT4 VAV3 VAV3 MET MET CAV1 CAV1 CAV2 CAV2 SHC4 SHC4 COL6A2 COL6A2 LAMC1 LAMC1 FLT1 FLT1 LAMC2 LAMC2 PAK5 PAK5 SHC2 SHC2 ITGA8 ITGA8 PIK3R1 PIK3R1 SPP1 SPP1 IBSP IBSP MAP2K1 MAP2K1 ITGA4 ITGA4 SHC3 SHC3 MAPK10 MAPK10 FN1 FN1 PAK2 PAK2 COL4A3 COL4A3 PIK3CD PIK3CD PRKCG PRKCG ITGB5 ITGB5 COL9A2 COL9A2 MYLK MYLK RAF1 RAF1 COL6A5 COL6A5 PANDA_017606 PANDA_017606 PDGFRB PDGFRB VTN VTN THBS2 THBS2 FLNC FLNC PPP1CB PPP1CB PXN PXN PIK3CB PIK3CB RAP1A RAP1A BCAR1 BCAR1 PAK1 PAK1 IGF1R IGF1R PARVA PARVA IGF1 IGF1 ROCK1 ROCK1 GSK3B GSK3B DOCK1 DOCK1 FLNA FLNA VAV1 VAV1 LAMA1 LAMA1 ITGA1 ITGA1 ITGA2 ITGA2 AKT1 AKT1 MYLPF MYLPF PIP5K1B PIP5K1B CRK CRK ITGAV ITGAV ARHGAP35 ARHGAP35 COL6A3 COL6A3 ITGB8 ITGB8 RAP1B RAP1B CRKL CRKL MAPK1 MAPK1 PARVB PARVB LAMA2 LAMA2 AKT3 AKT3 GRB2 GRB2 TLN1 TLN1 SOS2 SOS2 RAC2 RAC2 ERBB2 ERBB2 BIRC3 BIRC3 BIRC2 BIRC2 MYL9 MYL9 ACTN4 ACTN4 HRAS HRAS DIAPH1 DIAPH1 PIK3CA PIK3CA PDGFB PDGFB MYLK4 MYLK4 PIK3R2 PIK3R2 VAV2 VAV2 COMP COMP SHC1 SHC1 CTNNB1 CTNNB1 PRKCA PRKCA CHAD CHAD ITGA7 ITGA7 FLNB FLNB COL1A1 COL1A1 PAK3 PAK3 COL4A5 COL4A5 TLN2 TLN2 ITGA3 ITGA3 COL9A1 COL9A1 RASGRF1 RASGRF1 SRC SRC CAV3 CAV3 TNC TNC RHOA RHOA AKT2 AKT2 ITGB6 ITGB6 MYL12B MYL12B LAMB2 LAMB2 ITGA6 ITGA6 CCND3 CCND3 PPP1R12A PPP1R12A COL2A1 COL2A1 PDGFD PDGFD MYLK2 MYLK2 PIK3R3 PIK3R3 PPP1CC PPP1CC LAMA3 LAMA3 LAMB1 LAMB1 ITGA11 ITGA11 PRKCB PRKCB PDGFC PDGFC ITGB3 ITGB3 EGF EGF RELN RELN MAPK3 MAPK3 MYL10 MYL10 ARHGAP5 ARHGAP5 THBS4 THBS4 CCND2 CCND2 XIAP XIAP CAPN2 CAPN2 ACTG1 ACTG1 SOS1 SOS1 LAMC3 LAMC3 ILK ILK HGF HGF VCL VCL FYN FYN MYL5 MYL5 COL4A1 COL4A1 COL4A2 COL4A2 MAPK8 MAPK8 VEGFC VEGFC PAK6 PAK6 THBS1 THBS1 COL9A3 COL9A3 RAC3 RAC3 ITGB1 ITGB1 LAMA5 LAMA5 ITGA10 ITGA10 COL1A2 COL1A2 ITGA9 ITGA9 BAD BAD PDPK1 PDPK1 LAMB3 LAMB3 PGF PGF PDGFRA PDGFRA ITGA2B ITGA2B KDR KDR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
THBS3Thrombospondin 3. (957 aa)
PTENPhosphatase and tensin homolog. (403 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (562 aa)
MAPK9Mitogen-activated protein kinase. (425 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1052 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1361 aa)
VAV3Vav guanine nucleotide exchange factor 3. (847 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1400 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
SHC4SHC adaptor protein 4. (630 aa)
COL6A2Collagen type VI alpha 2 chain. (1014 aa)
LAMC1Laminin subunit gamma 1. (1593 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1339 aa)
LAMC2Laminin subunit gamma 2. (1192 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
SHC2Uncharacterized protein. (486 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1062 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (733 aa)
SPP1Secreted phosphoprotein 1. (298 aa)
IBSPIntegrin binding sialoprotein. (321 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1036 aa)
SHC3SHC adaptor protein 3. (492 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
FN1Fibronectin 1. (2476 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
COL4A3Collagen type IV alpha 3 chain. (1672 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1034 aa)
PRKCGProtein kinase C gamma; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (697 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (800 aa)
COL9A2Collagen type IX alpha 2 chain. (689 aa)
MYLKMyosin light chain kinase. (1914 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
COL6A5Collagen type VI alpha 5 chain. (2642 aa)
PANDA_017606Uncharacterized protein. (233 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1102 aa)
VTNSMB domain-containing protein. (470 aa)
THBS2Thrombospondin 2. (1179 aa)
FLNCFilamin C. (2722 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
PXNPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (590 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1071 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (894 aa)
PAK1Non-specific serine/threonine protein kinase. (551 aa)
IGF1RTyrosine-protein kinase receptor. (1369 aa)
PARVAParvin alpha. (351 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (106 aa)
ROCK1Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1353 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
DOCK1Uncharacterized protein; Belongs to the DOCK family. (913 aa)
FLNAFilamin A. (2523 aa)
VAV1Uncharacterized protein. (671 aa)
LAMA1Laminin subunit alpha 1. (3057 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1179 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1182 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
MYLPFMyosin light chain, phosphorylatable, fast skeletal muscle. (170 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (372 aa)
CRKCRK proto-oncogene, adaptor protein. (303 aa)
ITGAVIntegrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (576 aa)
ARHGAP35Rho GTPase activating protein 35. (1493 aa)
COL6A3Collagen type VI alpha 3 chain. (3178 aa)
ITGB8Integrin beta. (767 aa)
RAP1BUncharacterized protein. (184 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
MAPK1Mitogen-activated protein kinase. (320 aa)
PARVBParvin beta. (328 aa)
LAMA2Uncharacterized protein. (2526 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
GRB2Growth factor receptor bound protein 2. (192 aa)
TLN1Talin 1. (2553 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1314 aa)
RAC2Rac family small GTPase 2. (192 aa)
ERBB2Receptor protein-tyrosine kinase. (1263 aa)
BIRC3Baculoviral IAP repeat containing 3. (603 aa)
BIRC2Baculoviral IAP repeat containing 2. (621 aa)
MYL9Myosin light chain 9. (178 aa)
ACTN4Actinin alpha 4. (911 aa)
HRASHRas proto-oncogene, GTPase. (253 aa)
DIAPH1Diaphanous related formin 1. (1233 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (239 aa)
MYLK4Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. (323 aa)
PIK3R2Uncharacterized protein. (716 aa)
VAV2Vav guanine nucleotide exchange factor 2. (834 aa)
COMPCartilage oligomeric matrix protein. (759 aa)
SHC1SHC adaptor protein 1. (587 aa)
CTNNB1Catenin beta 1. (781 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (666 aa)
CHADChondroadherin. (359 aa)
ITGA7Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1181 aa)
FLNBFilamin B. (2604 aa)
COL1A1Collagen type I alpha 1 chain. (1464 aa)
PAK3P21 (RAC1) activated kinase 3. (580 aa)
COL4A5Collagen type IV alpha 5 chain. (1693 aa)
TLN2Talin 2. (2542 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1064 aa)
COL9A1Collagen type IX alpha 1 chain. (921 aa)
RASGRF1Ras protein specific guanine nucleotide releasing factor 1. (1275 aa)
SRCTyrosine-protein kinase. (542 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (154 aa)
TNCTenascin C. (2201 aa)
RHOARas homolog family member A. (193 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (788 aa)
MYL12BMyosin light chain 12B. (172 aa)
LAMB2Laminin subunit beta 2. (1797 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1109 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (294 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1029 aa)
COL2A1Collagen type II alpha 1 chain. (1488 aa)
PDGFDPlatelet derived growth factor D. (329 aa)
MYLK2Myosin light chain kinase 2. (624 aa)
PIK3R3Uncharacterized protein. (507 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (322 aa)
LAMA3Laminin subunit alpha 3. (3273 aa)
LAMB1Laminin subunit beta 1. (1831 aa)
ITGA11Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1173 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (661 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (790 aa)
EGFEpidermal growth factor. (864 aa)
RELNReelin. (3030 aa)
MAPK3Mitogen-activated protein kinase. (351 aa)
MYL10Myosin light chain 10. (176 aa)
ARHGAP5Rho GTPase activating protein 5. (1503 aa)
THBS4Thrombospondin 4. (984 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (291 aa)
XIAPX-linked inhibitor of apoptosis. (497 aa)
CAPN2Calpain 2; Belongs to the peptidase C2 family. (711 aa)
ACTG1Actin gamma 1; Belongs to the actin family. (375 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
LAMC3Laminin subunit gamma 3. (1529 aa)
ILKIntegrin linked kinase. (452 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
VCLVinculin. (1137 aa)
FYNTyrosine-protein kinase. (537 aa)
MYL5Myosin light chain 5. (172 aa)
COL4A1Collagen type IV alpha 1 chain. (1622 aa)
COL4A2Collagen type IV alpha 2 chain. (1643 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (416 aa)
PAK6Non-specific serine/threonine protein kinase. (680 aa)
THBS1Thrombospondin 1. (1182 aa)
COL9A3Collagen type IX alpha 3 chain. (685 aa)
RAC3Rac family small GTPase 3. (189 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
LAMA5Uncharacterized protein. (1635 aa)
ITGA10Integrin subunit alpha 10; Belongs to the integrin alpha chain family. (1167 aa)
COL1A2Collagen type I alpha 2 chain. (1437 aa)
ITGA9Integrin subunit alpha 9; Belongs to the integrin alpha chain family. (973 aa)
BADBCL2 associated agonist of cell death. (210 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (558 aa)
LAMB3Laminin subunit beta 3. (1172 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (228 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1040 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1420 aa)
Your Current Organism:
Ailuropoda melanoleuca
NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda
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