STRINGSTRING
JARID2 JARID2 MAPK13 MAPK13 ESX1 ESX1 MAPK14 MAPK14 SETDB1 SETDB1 WNT2 WNT2 ACVR1B ACVR1B ZFHX3 ZFHX3 MAP2K2 MAP2K2 MAPK12 MAPK12 MAPK11 MAPK11 ZIC3 ZIC3 SMAD4 SMAD4 PIK3R1 PIK3R1 MAP2K1 MAP2K1 SMAD3 SMAD3 WNT7B WNT7B WNT2B WNT2B IL6ST IL6ST PIK3CD PIK3CD WNT3 WNT3 WNT5B WNT5B WNT9B WNT9B PCGF2 PCGF2 SKIL SKIL RAF1 RAF1 INHBC INHBC INHBE INHBE HOXB1 HOXB1 PIK3CB PIK3CB OTX1 OTX1 KAT6A KAT6A DLX5 DLX5 IGF1R IGF1R SMARCAD1 SMARCAD1 HOXA1 HOXA1 ISL1 ISL1 BMPR1B BMPR1B WNT16 WNT16 BMI1 BMI1 FZD4 FZD4 STAT3 STAT3 IGF1 IGF1 LIFR LIFR FZD10 FZD10 WNT8B WNT8B PAX6 PAX6 GSK3B GSK3B WNT1 WNT1 AXIN1 AXIN1 WNT10B WNT10B KRAS KRAS AKT1 AKT1 LIF LIF ID2 ID2 INHBA INHBA RIF1 RIF1 INHBB INHBB MAPK1 MAPK1 AKT3 AKT3 GRB2 GRB2 WNT7A WNT7A ID3 ID3 JAK2 JAK2 BMPR1A BMPR1A HRAS HRAS PIK3CA PIK3CA JAK3 JAK3 SOX2 SOX2 PIK3R2 PIK3R2 FZD9 FZD9 WNT5A WNT5A CTNNB1 CTNNB1 HESX1 HESX1 AXIN2 AXIN2 AKT2 AKT2 APC APC SMAD2 SMAD2 BMPR2 BMPR2 MYF5 MYF5 ACVR2A ACVR2A ID1 ID1 PIK3R3 PIK3R3 DVL1 DVL1 ACVR1 ACVR1 ACVR1C ACVR1C G1M7T3_AILME G1M7T3_AILME WNT4 WNT4 MYC MYC JAK1 JAK1 MAPK3 MAPK3 BMP4 BMP4 FGFR1 FGFR1 MEIS1 MEIS1 FZD3 FZD3 WNT3A WNT3A WNT9A WNT9A FZD6 FZD6 WNT8A WNT8A DVL2 DVL2 SMAD1 SMAD1 HAND1 HAND1 PCGF3 PCGF3 PCGF5 PCGF5 WNT11 WNT11 KLF4 KLF4 NANOG NANOG NRAS NRAS PCGF1 PCGF1 DVL3 DVL3 FGF2 FGF2 ACVR2B ACVR2B NODAL NODAL PCGF6 PCGF6 SMAD5 SMAD5 FGFR4 FGFR4 ESRRB ESRRB FZD7 FZD7 FZD1 FZD1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
JARID2Jumonji and AT-rich interaction domain containing 2. (1248 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
ESX1Homeobox domain-containing protein. (269 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
SETDB1SET domain bifurcated histone lysine methyltransferase 1. (1298 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
ZFHX3Zinc finger homeobox 3. (3697 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
MAPK12Mitogen-activated protein kinase. (349 aa)
MAPK11Mitogen-activated protein kinase. (371 aa)
ZIC3Zic family member 3. (465 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (733 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
IL6STInterleukin 6 signal transducer. (918 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1034 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
PCGF2Polycomb group ring finger 2. (344 aa)
SKILSKI like proto-oncogene. (684 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
INHBCInhibin subunit beta C. (352 aa)
INHBEInhibin subunit beta E. (351 aa)
HOXB1Homeobox B1. (304 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1071 aa)
OTX1Orthodenticle homeobox 1. (350 aa)
KAT6AHistone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (1965 aa)
DLX5Distal-less homeobox 5. (289 aa)
IGF1RTyrosine-protein kinase receptor. (1369 aa)
SMARCAD1Uncharacterized protein. (1028 aa)
HOXA1Homeobox A1. (332 aa)
ISL1ISL LIM homeobox 1. (360 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (534 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
BMI1RING-type domain-containing protein. (326 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
STAT3Signal transducer and activator of transcription. (771 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (106 aa)
LIFRLIF receptor subunit alpha. (1100 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (580 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
PAX6Paired box 6. (439 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (368 aa)
AXIN1Axin 1. (866 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (404 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
INHBAInhibin subunit beta A. (424 aa)
RIF1Replication timing regulatory factor 1. (2450 aa)
INHBBInhibin subunit beta B. (340 aa)
MAPK1Mitogen-activated protein kinase. (320 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
GRB2Growth factor receptor bound protein 2. (192 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
ID3Inhibitor of DNA binding 3, HLH protein. (125 aa)
JAK2Tyrosine-protein kinase. (1057 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
HRASHRas proto-oncogene, GTPase. (253 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
JAK3Tyrosine-protein kinase. (1104 aa)
SOX2SRY-box transcription factor 2. (325 aa)
PIK3R2Uncharacterized protein. (716 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (462 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (378 aa)
CTNNB1Catenin beta 1. (781 aa)
HESX1HESX homeobox 1. (185 aa)
AXIN2Axin 2. (841 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
APCAPC regulator of WNT signaling pathway. (2848 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1040 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (153 aa)
PIK3R3Uncharacterized protein. (507 aa)
DVL1Dishevelled segment polarity protein 1. (700 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (495 aa)
G1M7T3_AILMELeft-right determination factor. (366 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (452 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
MAPK3Mitogen-activated protein kinase. (351 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
FGFR1Fibroblast growth factor receptor. (822 aa)
MEIS1Meis homeobox 1. (465 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
DVL2Dishevelled segment polarity protein 2. (731 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
HAND1Heart and neural crest derivatives expressed 1. (216 aa)
PCGF3Polycomb group ring finger 3. (246 aa)
PCGF5Polycomb group ring finger 5. (259 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
KLF4Kruppel like factor 4. (484 aa)
NANOGHomeobox domain-containing protein. (306 aa)
NRASNRAS proto-oncogene, GTPase. (193 aa)
PCGF1Polycomb group ring finger 1. (259 aa)
DVL3Uncharacterized protein. (710 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (96 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (508 aa)
NODALNodal growth differentiation factor. (343 aa)
PCGF6Polycomb group ring finger 6. (324 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
FGFR4Fibroblast growth factor receptor. (809 aa)
ESRRBEstrogen related receptor beta. (501 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (525 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (572 aa)
Your Current Organism:
Ailuropoda melanoleuca
NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.