(48 nodes) Antigen processing and presentation network (Ailuropoda melanoleuca)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RFX5	Regulatory factor X5. (619 aa)
	CTSS	Cathepsin S; Belongs to the peptidase C1 family. (337 aa)
	TAPBP	TAP binding protein. (462 aa)
	AIME-152	Ig-like domain-containing protein; Belongs to the MHC class I family. (366 aa)
	HLA-DOA	Major histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (252 aa)
	HLA-DMA	Major histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (261 aa)
	G1L599_AILME	Ig-like domain-containing protein. (268 aa)
	TAP1	Transporter 1, ATP binding cassette subfamily B member. (811 aa)
	TAP2	Uncharacterized protein. (768 aa)
	G1L5S3_AILME	Ig-like domain-containing protein. (276 aa)
	AIME-1906	Ig-like domain-containing protein; Belongs to the MHC class I family. (366 aa)
	HLA-DQB2	Major histocompatibility complex, class II, DQ beta 2. (256 aa)
	HLA-DRA	Major histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
	NFYA	Nuclear transcription factor Y subunit alpha. (348 aa)
	KLRD1	Killer cell lectin like receptor D1. (181 aa)
	CD74	CD74 molecule. (295 aa)
	HSP90AA1	Heat shock protein 90 alpha family class A member 1. (735 aa)
	CTSB	Cathepsin B; Belongs to the peptidase C1 family. (339 aa)
	CTSV	Cathepsin V; Belongs to the peptidase C1 family. (334 aa)
	NFYB	Nuclear transcription factor Y subunit beta. (205 aa)
	PSME3	Proteasome activator subunit 3. (266 aa)
	G1LKQ4_AILME	DUF1968 domain-containing protein. (125 aa)
	HSPA8	Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (646 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
	CANX	Calnexin. (594 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	CD8A	CD8a molecule. (268 aa)
	CD8B	Ig-like domain-containing protein. (205 aa)
	IFI30	IFI30 lysosomal thiol reductase. (249 aa)
	LOC100476216	Uncharacterized protein; Belongs to the peptidase C1 family. (341 aa)
	LOC100476469	Uncharacterized protein; Belongs to the peptidase C1 family. (333 aa)
	RFXANK	Regulatory factor X associated ankyrin containing protein. (260 aa)
	HSP90AB1	Heat shock protein 90 alpha family class B member 1. (741 aa)
	NFYC	Nuclear transcription factor Y subunit gamma. (458 aa)
	CALR	Calreticulin. (417 aa)
	LGMN	Legumain. (433 aa)
	CD4	Ig-like domain-containing protein. (412 aa)
	RFXAP	Regulatory factor X associated protein. (282 aa)
	CREB1	cAMP responsive element binding protein 1. (341 aa)
	PDIA3	Protein disulfide-isomerase. (505 aa)
	PSME1	Uncharacterized protein. (249 aa)
	HSPA5	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. (655 aa)
	HSPA4	Heat shock protein family A (Hsp70) member 4. (839 aa)
	HSPA1L	Heat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (641 aa)
	G1MKK0_AILME	Uncharacterized protein; Belongs to the heat shock protein 70 family. (643 aa)
	B2M	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (92 aa)
	G1MMC4_AILME	Ig-like domain-containing protein. (91 aa)
	HSPA2	Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (636 aa)

Your Current Organism:

Ailuropoda melanoleuca

NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIME-152	AIME-1906	ENSAMEP00000001813	ENSAMEP00000002421	Ig-like domain-containing protein; Belongs to the MHC class I family.	Ig-like domain-containing protein; Belongs to the MHC class I family.	0.901
AIME-152	B2M	ENSAMEP00000001813	ENSAMEP00000020170	Ig-like domain-containing protein; Belongs to the MHC class I family.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	0.997
AIME-152	CALR	ENSAMEP00000001813	ENSAMEP00000013174	Ig-like domain-containing protein; Belongs to the MHC class I family.	Calreticulin.	0.944
AIME-152	CD4	ENSAMEP00000001813	ENSAMEP00000014814	Ig-like domain-containing protein; Belongs to the MHC class I family.	Ig-like domain-containing protein.	0.444
AIME-152	CD8A	ENSAMEP00000001813	ENSAMEP00000010525	Ig-like domain-containing protein; Belongs to the MHC class I family.	CD8a molecule.	0.965
AIME-152	CD8B	ENSAMEP00000001813	ENSAMEP00000010534	Ig-like domain-containing protein; Belongs to the MHC class I family.	Ig-like domain-containing protein.	0.942
AIME-152	G1LKQ4_AILME	ENSAMEP00000001813	ENSAMEP00000007520	Ig-like domain-containing protein; Belongs to the MHC class I family.	DUF1968 domain-containing protein.	0.953
AIME-152	G1MMC4_AILME	ENSAMEP00000001813	ENSAMEP00000020515	Ig-like domain-containing protein; Belongs to the MHC class I family.	Ig-like domain-containing protein.	0.900
AIME-152	KLRD1	ENSAMEP00000001813	ENSAMEP00000004875	Ig-like domain-containing protein; Belongs to the MHC class I family.	Killer cell lectin like receptor D1.	0.942
AIME-152	PDIA3	ENSAMEP00000001813	ENSAMEP00000016090	Ig-like domain-containing protein; Belongs to the MHC class I family.	Protein disulfide-isomerase.	0.943
AIME-152	TAP1	ENSAMEP00000001813	ENSAMEP00000002122	Ig-like domain-containing protein; Belongs to the MHC class I family.	Transporter 1, ATP binding cassette subfamily B member.	0.421
AIME-152	TAPBP	ENSAMEP00000001813	ENSAMEP00000001603	Ig-like domain-containing protein; Belongs to the MHC class I family.	TAP binding protein.	0.958
AIME-1906	AIME-152	ENSAMEP00000002421	ENSAMEP00000001813	Ig-like domain-containing protein; Belongs to the MHC class I family.	Ig-like domain-containing protein; Belongs to the MHC class I family.	0.901
AIME-1906	B2M	ENSAMEP00000002421	ENSAMEP00000020170	Ig-like domain-containing protein; Belongs to the MHC class I family.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	0.959
AIME-1906	CALR	ENSAMEP00000002421	ENSAMEP00000013174	Ig-like domain-containing protein; Belongs to the MHC class I family.	Calreticulin.	0.944
AIME-1906	CD4	ENSAMEP00000002421	ENSAMEP00000014814	Ig-like domain-containing protein; Belongs to the MHC class I family.	Ig-like domain-containing protein.	0.510
AIME-1906	CD8A	ENSAMEP00000002421	ENSAMEP00000010525	Ig-like domain-containing protein; Belongs to the MHC class I family.	CD8a molecule.	0.965
AIME-1906	CD8B	ENSAMEP00000002421	ENSAMEP00000010534	Ig-like domain-containing protein; Belongs to the MHC class I family.	Ig-like domain-containing protein.	0.942
AIME-1906	G1LKQ4_AILME	ENSAMEP00000002421	ENSAMEP00000007520	Ig-like domain-containing protein; Belongs to the MHC class I family.	DUF1968 domain-containing protein.	0.953
AIME-1906	G1MMC4_AILME	ENSAMEP00000002421	ENSAMEP00000020515	Ig-like domain-containing protein; Belongs to the MHC class I family.	Ig-like domain-containing protein.	0.900