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MAPK13 MAPK13 MAPK14 MAPK14 SST SST MAPK9 MAPK9 GHSR GHSR ITPR3 ITPR3 SHC4 SHC4 MAP2K2 MAP2K2 LOC100467700 LOC100467700 ATF6B ATF6B PLCB1 PLCB1 MAPK12 MAPK12 MAPK11 MAPK11 PLCB4 PLCB4 ADCY3 ADCY3 SHC2 SHC2 ADCY2 ADCY2 GH1 GH1 PIK3R1 PIK3R1 MAP2K1 MAP2K1 SHC3 SHC3 MAPK10 MAPK10 MAP3K1 MAP3K1 GHR GHR PIK3CD PIK3CD CACNA1C CACNA1C G1LCN2_AILME G1LCN2_AILME PRKCG PRKCG RAF1 RAF1 ADCY5 ADCY5 GNAI3 GNAI3 GNAQ GNAQ PIK3CB PIK3CB GNA11 GNA11 BCAR1 BCAR1 CREB5 CREB5 STAT3 STAT3 IGF1 IGF1 CREB3L1 CREB3L1 ADCY7 ADCY7 GSK3B GSK3B ADCY6 ADCY6 MAP2K6 MAP2K6 KRAS KRAS AKT1 AKT1 CRK CRK CRKL CRKL MAPK1 MAPK1 AKT3 AKT3 GRB2 GRB2 MTOR MTOR PLCG1 PLCG1 CREB3 CREB3 JAK2 JAK2 SOS2 SOS2 SOCS2 SOCS2 HRAS HRAS PIK3CA PIK3CA CREBBP CREBBP ADCY9 ADCY9 ATF4 ATF4 PIK3R2 PIK3R2 SHC1 SHC1 PRKCA PRKCA GNAI2 GNAI2 ITPR2 ITPR2 CREB3L4 CREB3L4 CACNA1F CACNA1F MAP2K3 MAP2K3 GHRH GHRH ATF2 ATF2 CACNA1S CACNA1S AKT2 AKT2 ADCY8 ADCY8 MAP2K4 MAP2K4 PRKACA PRKACA PRKACB PRKACB PIK3R3 PIK3R3 EP300 EP300 PLCG2 PLCG2 PRKCB PRKCB IGFBP3 IGFBP3 ADCY1 ADCY1 G1M8X5_AILME G1M8X5_AILME CREB1 CREB1 MAPK3 MAPK3 GHRL GHRL ITPR1 ITPR1 ADCY4 ADCY4 SOS1 SOS1 GNAI1 GNAI1 MAPK8 MAPK8 NRAS NRAS PLCB3 PLCB3 CREB3L2 CREB3L2 FOS FOS SSTR1 SSTR1 SOCS3 SOCS3 SSTR2 SSTR2 LOC100469231 LOC100469231 SSTR3 SSTR3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK13Mitogen-activated protein kinase. (366 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
SSTSomatostatin. (117 aa)
MAPK9Mitogen-activated protein kinase. (425 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2672 aa)
SHC4SHC adaptor protein 4. (630 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
LOC100467700Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2020 aa)
ATF6BActivating transcription factor 6 beta. (699 aa)
PLCB1Phosphoinositide phospholipase C. (1135 aa)
MAPK12Mitogen-activated protein kinase. (349 aa)
MAPK11Mitogen-activated protein kinase. (371 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1151 aa)
SHC2Uncharacterized protein. (486 aa)
ADCY2Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (289 aa)
GH1Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues (By similarity); Belongs to the somatotropin/prolactin family. (216 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (733 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
SHC3SHC adaptor protein 3. (492 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1348 aa)
GHRGrowth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity). (637 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1034 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1978 aa)
G1LCN2_AILMEGuanylate cyclase domain-containing protein. (1466 aa)
PRKCGProtein kinase C gamma; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (697 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
ADCY5Adenylate cyclase 5. (1083 aa)
GNAI3G protein subunit alpha i3. (326 aa)
GNAQUncharacterized protein. (253 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1071 aa)
GNA11G protein subunit alpha 11. (356 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (894 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
STAT3Signal transducer and activator of transcription. (771 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (106 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1110 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1157 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CRKCRK proto-oncogene, adaptor protein. (303 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
MAPK1Mitogen-activated protein kinase. (320 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
GRB2Growth factor receptor bound protein 2. (192 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2544 aa)
PLCG1Phosphoinositide phospholipase C. (1294 aa)
CREB3cAMP responsive element binding protein 3. (352 aa)
JAK2Tyrosine-protein kinase. (1057 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1314 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
HRASHRas proto-oncogene, GTPase. (253 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
CREBBPCREB binding protein. (2370 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
ATF4Activating transcription factor 4. (382 aa)
PIK3R2Uncharacterized protein. (716 aa)
SHC1SHC adaptor protein 1. (587 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (666 aa)
GNAI2G protein subunit alpha i2. (355 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (393 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1985 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
GHRHGrowth hormone releasing hormone. (107 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1874 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ADCY8Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1249 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (324 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (343 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
PIK3R3Uncharacterized protein. (507 aa)
EP300E1A binding protein p300. (2421 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (661 aa)
IGFBP3Thyroglobulin type-1 domain-containing protein. (193 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1049 aa)
G1M8X5_AILMEPH domain-containing protein. (507 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
MAPK3Mitogen-activated protein kinase. (351 aa)
GHRLUncharacterized protein. (110 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2695 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1109 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
GNAI1G protein subunit alpha i1. (354 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
NRASNRAS proto-oncogene, GTPase. (193 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1203 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
SSTR1Somatostatin receptor 1; Belongs to the G-protein coupled receptor 1 family. (391 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
SSTR2Somatostatin receptor 2; Belongs to the G-protein coupled receptor 1 family. (369 aa)
LOC100469231Uncharacterized protein. (245 aa)
SSTR3Somatostatin receptor 3; Belongs to the G-protein coupled receptor 1 family. (422 aa)
Your Current Organism:
Ailuropoda melanoleuca
NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda
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