STRINGSTRING
CDKN1A CDKN1A IKBKG IKBKG MAPK13 MAPK13 MAPK14 MAPK14 MAPK9 MAPK9 ITPR3 ITPR3 BAK1 BAK1 AIME-152 AIME-152 LYN LYN CALM2-2 CALM2-2 LEF1 LEF1 TCF7L1 TCF7L1 GNG2 GNG2 MAP2K2 MAP2K2 AIME-1906 AIME-1906 MAPK12 MAPK12 MAPK11 MAPK11 LOC100477312 LOC100477312 PIK3R1 PIK3R1 GNG4 GNG4 PPP3CC PPP3CC HIF1A HIF1A MAP2K1 MAP2K1 MAPK10 MAPK10 IL6ST IL6ST RB1 RB1 GABARAPL1 GABARAPL1 STAT2 STAT2 CLEC2B CLEC2B RPS27A RPS27A PIK3CD PIK3CD RAF1 RAF1 CXCL8 CXCL8 GNGT2 GNGT2 TLR3 TLR3 PIK3CB PIK3CB RCAN1 RCAN1 IKBKB IKBKB ANGPT2 ANGPT2 CDK4 CDK4 GABARAPL2 GABARAPL2 GNG7 GNG7 CYCS CYCS CASP8 CASP8 STAT3 STAT3 GNG3 GNG3 BECN1 BECN1 CHUK CHUK ATG14 ATG14 GSK3B GSK3B FADD FADD GNB5 GNB5 C3 C3 MAP2K6 MAP2K6 GNG13 GNG13 PIK3C3 PIK3C3 KRAS KRAS AKT1 AKT1 NFATC3 NFATC3 CASP3 CASP3 ZFP36 ZFP36 GNG5 GNG5 GNG8 GNG8 PPP3CA PPP3CA MAPK1 MAPK1 NFKB1 NFKB1 AKT3 AKT3 MTOR MTOR PLCG1 PLCG1 E2F2 E2F2 JAK2 JAK2 IFNGR1 IFNGR1 NFATC1 NFATC1 HRAS HRAS IRF7 IRF7 PIK3CA PIK3CA PDGFB PDGFB CREBBP CREBBP GNB4 GNB4 PIK3R2 PIK3R2 UBA52 UBA52 CTNNB1 CTNNB1 TYK2 TYK2 ICAM1 ICAM1 ITPR2 ITPR2 CASP9 CASP9 GNG14 GNG14 SRC SRC AKT2 AKT2 MAP2K4 MAP2K4 TRAF2 TRAF2 NFATC2 NFATC2 PIK3CG PIK3CG HCK HCK CALML6 CALML6 GNB1 GNB1 PIK3R3 PIK3R3 PREX1 PREX1 IRF3 IRF3 EP300 EP300 GNB3 GNB3 PLCG2 PLCG2 CD86 CD86 CXCL2 CXCL2 TNFRSF1A TNFRSF1A BAX BAX MYC MYC GNB2 GNB2 IFNAR1 IFNAR1 IFNAR2 IFNAR2 CREB1 CREB1 JAK1 JAK1 MAPK3 MAPK3 PTGS2 PTGS2 NFKBIA NFKBIA NFATC4 NFATC4 ITPR1 ITPR1 IRF9 IRF9 GABARAP GABARAP TP53 TP53 PPP3CB PPP3CB MAPK8 MAPK8 NRAS NRAS TRADD TRADD RELA RELA SYK SYK BID BID FGF2 FGF2 MAPKAPK2 MAPKAPK2 EIF2AK2 EIF2AK2 CSF2 CSF2 GNG11 GNG11 GNGT1 GNGT1 CDK6 CDK6 E2F3 E2F3 G1MID4_AILME G1MID4_AILME G1MID6_AILME G1MID6_AILME ATG3 ATG3 TBK1 TBK1 TRAF3 TRAF3 FOS FOS BECN2 BECN2 UBB UBB CCR1 CCR1 CALML5 CALML5 G1MMC4_AILME G1MMC4_AILME CCR3 CCR3 LOC100484770 LOC100484770 CCR5 CCR5 GNG10 GNG10 CCR4 CCR4 IFNB1 IFNB1 LOC100477562 LOC100477562 LOC100477057 LOC100477057 CCR8 CCR8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDKN1ACyclin dependent kinase inhibitor 1A. (167 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (423 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK9Mitogen-activated protein kinase. (425 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2672 aa)
BAK1BCL2 antagonist/killer 1. (216 aa)
AIME-152Ig-like domain-containing protein; Belongs to the MHC class I family. (366 aa)
LYNTyrosine-protein kinase. (512 aa)
CALM2-2Calmodulin 2; Belongs to the calmodulin family. (148 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
TCF7L1Transcription factor 7 like 1. (578 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
AIME-1906Ig-like domain-containing protein; Belongs to the MHC class I family. (366 aa)
MAPK12Mitogen-activated protein kinase. (349 aa)
MAPK11Mitogen-activated protein kinase. (371 aa)
LOC100477312Uncharacterized protein. (193 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (733 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
PPP3CCSerine/threonine-protein phosphatase. (509 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (823 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
IL6STInterleukin 6 signal transducer. (918 aa)
RB1RB transcriptional corepressor 1. (906 aa)
GABARAPL1GABA type A receptor associated protein like 1. (122 aa)
STAT2Signal transducer and activator of transcription. (859 aa)
CLEC2BC-type lectin domain family 2 member B. (147 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1034 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (95 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (905 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1071 aa)
RCAN1Regulator of calcineurin 1. (247 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (755 aa)
ANGPT2Angiopoietin 2. (496 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
GABARAPL2GABA type A receptor associated protein like 2. (121 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
CYCSCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (486 aa)
STAT3Signal transducer and activator of transcription. (771 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
BECN1Beclin 1. (448 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (747 aa)
ATG14Autophagy related 14. (419 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (221 aa)
GNB5G protein subunit beta 5. (395 aa)
C3Complement C3. (1702 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
GNG13G protein subunit gamma 13. (67 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (889 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
NFATC3Nuclear factor of activated T cells 3. (1075 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
ZFP36ZFP36 ring finger protein. (325 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
MAPK1Mitogen-activated protein kinase. (320 aa)
NFKB1Uncharacterized protein. (781 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2544 aa)
PLCG1Phosphoinositide phospholipase C. (1294 aa)
E2F2E2F transcription factor 2. (440 aa)
JAK2Tyrosine-protein kinase. (1057 aa)
IFNGR1Interferon gamma receptor 1. (472 aa)
NFATC1Nuclear factor of activated T cells 1. (928 aa)
HRASHRas proto-oncogene, GTPase. (253 aa)
IRF7Interferon regulatory factor 7. (487 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (239 aa)
CREBBPCREB binding protein. (2370 aa)
GNB4G protein subunit beta 4. (340 aa)
PIK3R2Uncharacterized protein. (716 aa)
UBA52Ribosomal protein L40. (128 aa)
CTNNB1Catenin beta 1. (781 aa)
TYK2Tyrosine-protein kinase. (1186 aa)
ICAM1Uncharacterized protein. (332 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (451 aa)
GNG14Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
SRCTyrosine-protein kinase. (542 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (324 aa)
TRAF2TNF receptor associated factor 2. (523 aa)
NFATC2Nuclear factor of activated T cells 2. (908 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
HCKTyrosine-protein kinase. (526 aa)
CALML6Calmodulin like 6. (165 aa)
GNB1G protein subunit beta 1. (340 aa)
PIK3R3Uncharacterized protein. (507 aa)
PREX1Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1618 aa)
IRF3Interferon regulatory factor 3. (421 aa)
EP300E1A binding protein p300. (2421 aa)
GNB3G protein subunit beta 3. (340 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
CD86CD86 molecule. (329 aa)
CXCL2C-X-C motif chemokine. (107 aa)
TNFRSF1ATNF receptor superfamily member 1A. (454 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (452 aa)
GNB2G protein subunit beta 2. (340 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (563 aa)
IFNAR2Uncharacterized protein. (520 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
MAPK3Mitogen-activated protein kinase. (351 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
NFKBIANFKB inhibitor alpha. (315 aa)
NFATC4Nuclear factor of activated T cells 4. (954 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2695 aa)
IRF9Interferon regulatory factor 9. (443 aa)
GABARAPGABA type A receptor-associated protein. (117 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
PPP3CBSerine/threonine-protein phosphatase. (522 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
NRASNRAS proto-oncogene, GTPase. (193 aa)
TRADDTNFRSF1A associated via death domain. (311 aa)
RELARELA proto-oncogene, NF-kB subunit. (528 aa)
SYKTyrosine-protein kinase. (630 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (195 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (96 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (408 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (555 aa)
CSF2Colony stimulating factor 2. (151 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
E2F3E2F transcription factor 3. (335 aa)
G1MID4_AILMEIg-like domain-containing protein. (186 aa)
G1MID6_AILMEIg-like domain-containing protein. (291 aa)
ATG3Autophagy-related protein 3. (314 aa)
TBK1TANK binding kinase 1. (729 aa)
TRAF3TNF receptor associated factor 3. (568 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
BECN2Beclin 2. (443 aa)
UBBUbiquitin B. (229 aa)
CCR1C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
CALML5Calmodulin like 5. (149 aa)
G1MMC4_AILMEIg-like domain-containing protein. (91 aa)
CCR3C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (359 aa)
LOC100484770Uncharacterized protein; Belongs to the calmodulin family. (149 aa)
CCR5C-C motif chemokine receptor 5 (gene/pseudogene); Belongs to the G-protein coupled receptor 1 family. (352 aa)
GNG10G protein gamma domain-containing protein. (41 aa)
CCR4C-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (360 aa)
IFNB1Interferon beta 1. (186 aa)
LOC100477562Uncharacterized protein. (188 aa)
LOC100477057Uncharacterized protein. (187 aa)
CCR8C-C motif chemokine receptor 8; Belongs to the G-protein coupled receptor 1 family. (354 aa)
Your Current Organism:
Ailuropoda melanoleuca
NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda
Server load: low (16%) [HD]