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HPN HPN CDKN1A CDKN1A YWHAZ YWHAZ IKBKG IKBKG KAT2B KAT2B GSN GSN CHEK1 CHEK1 TRAF1 TRAF1 TRAF5 TRAF5 BAK1 BAK1 GTF2E2 GTF2E2 CDC20 CDC20 AIME-152 AIME-152 LYN LYN PSMC1 PSMC1 DNAJA3 DNAJA3 GTF2A1 GTF2A1 VAC14 VAC14 AIME-1906 AIME-1906 ATF6B ATF6B HDAC10 HDAC10 ATP6V0D2 ATP6V0D2 UBR4 UBR4 EGR3 EGR3 PIK3R1 PIK3R1 CDK2 CDK2 LOC100465141 LOC100465141 CDK1 CDK1 DLG1 DLG1 IL6ST IL6ST RB1 RB1 EGR2 EGR2 HNRNPK HNRNPK YWHAB YWHAB PIK3CD PIK3CD SND1 SND1 GTF2E1 GTF2E1 VDAC3 VDAC3 POLB POLB PXN PXN PIK3CB PIK3CB CDK4 CDK4 CCNE2 CCNE2 G1LGB9_AILME G1LGB9_AILME GTF2A2 GTF2A2 CREB5 CREB5 HDAC8 HDAC8 KAT2A KAT2A CASP8 CASP8 CCNA2 CCNA2 STAT3 STAT3 SCRIB SCRIB CREB3L1 CREB3L1 DDX3X DDX3X YWHAH YWHAH UBE3A UBE3A H2BC18 H2BC18 C3 C3 CDKN2B CDKN2B KRAS KRAS HDAC1 HDAC1 YWHAE YWHAE CASP3 CASP3 HDAC9 HDAC9 MDM2 MDM2 YWHAQ YWHAQ MAPK1 MAPK1 NFKB1 NFKB1 GRB2 GRB2 HDAC11 HDAC11 CCNE1 CCNE1 CREB3 CREB3 SCIN SCIN G1LU99_AILME G1LU99_AILME ACTN4 ACTN4 CCNA1 CCNA1 HDAC3 HDAC3 HRAS HRAS TBPL2 TBPL2 IRF7 IRF7 CDKN1B CDKN1B USP7 USP7 PIK3CA PIK3CA YWHAG YWHAG CREBBP CREBBP JAK3 JAK3 ATF4 ATF4 PIK3R2 PIK3R2 HDAC4 HDAC4 RANBP1 RANBP1 CREB3L4 CREB3L4 SRC SRC SKP2 SKP2 ATF2 ATF2 RBL1 RBL1 SRF SRF HDAC6 HDAC6 RHOA RHOA CCND3 CCND3 GTF2H4 GTF2H4 PRKACA PRKACA HDAC2 HDAC2 MRPS18B MRPS18B TRAF2 TRAF2 PRKACB PRKACB PIK3R3 PIK3R3 IRF3 IRF3 EP300 EP300 CHD4 CHD4 LTBR LTBR BAX BAX CREB1 CREB1 JAK1 JAK1 MAD1L1 MAD1L1 MAPK3 MAPK3 GTF2H3 GTF2H3 NFKBIA NFKBIA CCND2 CCND2 G1MBX4_AILME G1MBX4_AILME G1MBX7_AILME G1MBX7_AILME TBPL1 TBPL1 GTF2B GTF2B RBL2 RBL2 IRF9 IRF9 RASA2 RASA2 DDB1 DDB1 TP53 TP53 TBP TBP NRAS NRAS TRADD TRADD RELA RELA ATP6V0D1 ATP6V0D1 SYK SYK MAPKAPK2 MAPKAPK2 EIF2AK2 EIF2AK2 NFKB2 NFKB2 CDK6 CDK6 GTF2H1 GTF2H1 BAD BAD CREB3L2 CREB3L2 RBPJ RBPJ TRAF3 TRAF3 REL REL HDAC5 HDAC5 CDKN2A CDKN2A G1MMC4_AILME G1MMC4_AILME CCR3 CCR3 G1MMD8_AILME G1MMD8_AILME CCR5 CCR5 LOC100464367 LOC100464367 CCR4 CCR4 CCR8 CCR8 LOC100468151 LOC100468151
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HPNHepsin; Belongs to the peptidase S1 family. (417 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (167 aa)
YWHAZTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (245 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (423 aa)
KAT2BLysine acetyltransferase 2B. (754 aa)
GSNGelsolin. (773 aa)
CHEK1Checkpoint kinase 1. (439 aa)
TRAF1TNF receptor associated factor 1. (414 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa)
BAK1BCL2 antagonist/killer 1. (216 aa)
GTF2E2General transcription factor IIE subunit 2. (290 aa)
CDC20Cell division cycle 20. (499 aa)
AIME-152Ig-like domain-containing protein; Belongs to the MHC class I family. (366 aa)
LYNTyrosine-protein kinase. (512 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa)
DNAJA3DnaJ heat shock protein family (Hsp40) member A3. (480 aa)
GTF2A1General transcription factor IIA subunit 1. (376 aa)
VAC14VAC14 component of PIKFYVE complex. (785 aa)
AIME-1906Ig-like domain-containing protein; Belongs to the MHC class I family. (366 aa)
ATF6BActivating transcription factor 6 beta. (699 aa)
HDAC10Histone deacetylase 10. (669 aa)
ATP6V0D2ATPase H+ transporting V0 subunit d2. (351 aa)
UBR4Ubiquitin protein ligase E3 component n-recognin 4. (5148 aa)
EGR3Early growth response 3. (382 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (733 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
LOC100465141General transcription factor IIH subunit. (395 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (265 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (766 aa)
IL6STInterleukin 6 signal transducer. (918 aa)
RB1RB transcriptional corepressor 1. (906 aa)
EGR2Early growth response 2. (471 aa)
HNRNPKHeterogeneous nuclear ribonucleoprotein K. (464 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1034 aa)
SND1Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. (966 aa)
GTF2E1General transcription factor IIE subunit 1. (438 aa)
VDAC3Voltage dependent anion channel 3. (294 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa)
PXNPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (590 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1071 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
G1LGB9_AILMEHistone domain-containing protein; Belongs to the histone H2B family. (141 aa)
GTF2A2General transcription factor IIA subunit 2. (102 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
HDAC8Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (377 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (836 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (486 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (431 aa)
STAT3Signal transducer and activator of transcription. (771 aa)
SCRIBScribble planar cell polarity protein. (1601 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (675 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (247 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (877 aa)
H2BC18Histone H2B; Belongs to the histone H2B family. (134 aa)
C3Complement C3. (1702 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (131 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (485 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1068 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (493 aa)
YWHAQTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta; Belongs to the 14-3-3 family. (245 aa)
MAPK1Mitogen-activated protein kinase. (320 aa)
NFKB1Uncharacterized protein. (781 aa)
GRB2Growth factor receptor bound protein 2. (192 aa)
HDAC11Histone deacetylase 11. (347 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (410 aa)
CREB3cAMP responsive element binding protein 3. (352 aa)
SCINScinderin. (717 aa)
G1LU99_AILMEHistone H2B; Belongs to the histone H2B family. (172 aa)
ACTN4Actinin alpha 4. (911 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (426 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
HRASHRas proto-oncogene, GTPase. (253 aa)
TBPL2Uncharacterized protein. (263 aa)
IRF7Interferon regulatory factor 7. (487 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (200 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1112 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
YWHAGTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (247 aa)
CREBBPCREB binding protein. (2370 aa)
JAK3Tyrosine-protein kinase. (1104 aa)
ATF4Activating transcription factor 4. (382 aa)
PIK3R2Uncharacterized protein. (716 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1087 aa)
RANBP1RAN binding protein 1. (209 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (393 aa)
SRCTyrosine-protein kinase. (542 aa)
SKP2S-phase kinase associated protein 2. (424 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
RBL1RB transcriptional corepressor like 1. (1067 aa)
SRFSerum response factor. (444 aa)
HDAC6Histone deacetylase 6. (1174 aa)
RHOARas homolog family member A. (193 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (294 aa)
GTF2H4General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (463 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (343 aa)
HDAC2Histone deacetylase 2. (578 aa)
MRPS18BMitochondrial ribosomal protein S18B. (258 aa)
TRAF2TNF receptor associated factor 2. (523 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
PIK3R3Uncharacterized protein. (507 aa)
IRF3Interferon regulatory factor 3. (421 aa)
EP300E1A binding protein p300. (2421 aa)
CHD4Uncharacterized protein. (1929 aa)
LTBRLymphotoxin beta receptor. (421 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
MAD1L1Uncharacterized protein. (267 aa)
MAPK3Mitogen-activated protein kinase. (351 aa)
GTF2H3General transcription factor IIH subunit 3. (309 aa)
NFKBIANFKB inhibitor alpha. (315 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (291 aa)
G1MBX4_AILMEHistone H2B; Belongs to the histone H2B family. (136 aa)
G1MBX7_AILMEHistone H2B; Belongs to the histone H2B family. (135 aa)
TBPL1TATA-box binding protein like 1. (186 aa)
GTF2BGeneral transcription factor IIB. (316 aa)
RBL2RB transcriptional corepressor like 2. (1137 aa)
IRF9Interferon regulatory factor 9. (443 aa)
RASA2Uncharacterized protein. (511 aa)
DDB1Damage specific DNA binding protein 1. (1140 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
TBPTATA-box binding protein. (324 aa)
NRASNRAS proto-oncogene, GTPase. (193 aa)
TRADDTNFRSF1A associated via death domain. (311 aa)
RELARELA proto-oncogene, NF-kB subunit. (528 aa)
ATP6V0D1ATPase H+ transporting V0 subunit d1. (351 aa)
SYKTyrosine-protein kinase. (630 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (408 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (555 aa)
NFKB2Nuclear factor kappa B subunit 2. (901 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
GTF2H1General transcription factor IIH subunit 1. (547 aa)
BADBCL2 associated agonist of cell death. (210 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (480 aa)
TRAF3TNF receptor associated factor 3. (568 aa)
RELREL proto-oncogene, NF-kB subunit. (592 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1111 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (103 aa)
G1MMC4_AILMEIg-like domain-containing protein. (91 aa)
CCR3C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (359 aa)
G1MMD8_AILMEHistone domain-containing protein; Belongs to the histone H2B family. (126 aa)
CCR5C-C motif chemokine receptor 5 (gene/pseudogene); Belongs to the G-protein coupled receptor 1 family. (352 aa)
LOC100464367Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
CCR4C-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (360 aa)
CCR8C-C motif chemokine receptor 8; Belongs to the G-protein coupled receptor 1 family. (354 aa)
LOC100468151Histone H2B; Belongs to the histone H2B family. (127 aa)
Your Current Organism:
Ailuropoda melanoleuca
NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda
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