STRINGSTRING
HPSE2 HPSE2 CDKN1A CDKN1A MAPK13 MAPK13 MAPK14 MAPK14 PPP1CA PPP1CA RPS6KB2 RPS6KB2 ITGA5 ITGA5 VAV3 VAV3 SHH SHH WNT2 WNT2 MET MET CAV1 CAV1 CAV2 CAV2 ITPR3 ITPR3 GPC3 GPC3 MSN MSN NUDT16L1 NUDT16L1 HOXD10 HOXD10 TFAP4 TFAP4 IGF2 IGF2 MAP2K2 MAP2K2 RRAS2 RRAS2 MAPK12 MAPK12 MAPK11 MAPK11 IHH IHH DDX5 DDX5 SDC1 SDC1 RPS6 RPS6 PIK3R1 PIK3R1 HIF1A HIF1A MAP2K1 MAP2K1 ERBB3 ERBB3 WNT7B WNT7B ANK3 ANK3 WNT2B WNT2B FN1 FN1 PIK3CD PIK3CD C11orf1 C11orf1 SDC4 SDC4 PLAUR PLAUR WNT3 WNT3 WNT5B WNT5B WNT9B WNT9B DCN DCN PRKCG PRKCG ITGB5 ITGB5 RAF1 RAF1 HPSE HPSE VTN VTN FLNC FLNC PPP1CB PPP1CB PXN PXN SMO SMO PIK3CB PIK3CB PAK1 PAK1 IGF1R IGF1R TLR4 TLR4 WNT16 WNT16 DROSHA DROSHA FZD4 FZD4 STAT3 STAT3 IGF1 IGF1 IL12B IL12B CTSV CTSV FZD10 FZD10 WNT8B WNT8B ROCK1 ROCK1 WNT1 WNT1 WNT10B WNT10B FLNA FLNA SDC2 SDC2 ERBB4 ERBB4 CTTN CTTN VAV1 VAV1 KRAS KRAS ITGA2 ITGA2 AKT1 AKT1 CBL CBL ARHGEF12 ARHGEF12 ITGAV ITGAV CASP3 CASP3 TWIST1 TWIST1 MDM2 MDM2 PTPN11 PTPN11 MAPK1 MAPK1 RDX RDX CAMK2D CAMK2D ANK2 ANK2 AKT3 AKT3 GRB2 GRB2 EZR EZR TNF TNF WNT7A WNT7A MTOR MTOR PLCG1 PLCG1 GAB1 GAB1 SOS2 SOS2 ERBB2 ERBB2 HRAS HRAS PIK3CA PIK3CA SLC9A1 SLC9A1 PIK3R2 PIK3R2 ESR1 ESR1 FZD9 FZD9 HBEGF HBEGF VAV2 VAV2 RPS6KB1 RPS6KB1 LOC100476216 LOC100476216 LOC100476469 LOC100476469 WNT5A WNT5A CTNNB1 CTNNB1 PTCH1 PTCH1 CD63 CD63 PRKCA PRKCA FRS2 FRS2 ITPR2 ITPR2 FLNB FLNB COL1A1 COL1A1 EIF4B EIF4B SRC SRC CAV3 CAV3 RHOA RHOA AKT2 AKT2 MMP9 MMP9 SMAD2 SMAD2 ARAF ARAF PRKACA PRKACA PPP1R12A PPP1R12A PRKACB PRKACB PLCE1 PLCE1 PIK3R3 PIK3R3 PTPN6 PTPN6 PPP1CC PPP1CC RRAS RRAS ZNF774 ZNF774 PLCG2 PLCG2 PRKCB PRKCB HSPG2 HSPG2 WNT4 WNT4 LUM LUM MYC MYC ITGB3 ITGB3 HCLS1 HCLS1 TIAM1 TIAM1 MAPK3 MAPK3 FASLG FASLG FGFR1 FGFR1 PDCD4 PDCD4 FZD3 FZD3 ACTG1 ACTG1 ITPR1 ITPR1 SOS1 SOS1 TIMP3 TIMP3 WNT3A WNT3A WNT9A WNT9A FZD6 FZD6 WNT8A WNT8A MMP2 MMP2 HGF HGF LOC100471152 LOC100471152 PLAU PLAU TP53 TP53 WNT11 WNT11 NANOG NANOG NRAS NRAS THBS1 THBS1 ITGB1 ITGB1 FGF2 FGF2 COL1A2 COL1A2 PDPK1 PDPK1 KDR KDR TLR2 TLR2 FZD7 FZD7 FZD1 FZD1 TWIST2 TWIST2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HPSE2Uncharacterized protein. (260 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (167 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1052 aa)
VAV3Vav guanine nucleotide exchange factor 3. (847 aa)
SHHSonic hedgehog signaling molecule. (267 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1400 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2672 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (580 aa)
MSNMoesin. (573 aa)
NUDT16L1Nudix hydrolase 16 like 1. (210 aa)
HOXD10Homeobox D10. (340 aa)
TFAP4Transcription factor AP-4. (337 aa)
IGF2Insulin like growth factor 2. (238 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
RRAS2RAS related 2. (175 aa)
MAPK12Mitogen-activated protein kinase. (349 aa)
MAPK11Mitogen-activated protein kinase. (371 aa)
IHHIndian hedgehog signaling molecule. (360 aa)
DDX5DEAD-box helicase 5; Belongs to the DEAD box helicase family. (671 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (302 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (733 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (823 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1339 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
ANK3Ankyrin 3. (4367 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
FN1Fibronectin 1. (2476 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1034 aa)
C11orf1Chromosome 11 open reading frame 1. (136 aa)
SDC4Syndecan 4. (206 aa)
PLAURPlasminogen activator, urokinase receptor. (337 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
DCNDecorin; May affect the rate of fibrils formation. (310 aa)
PRKCGProtein kinase C gamma; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (697 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (800 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
HPSEHeparanase. (543 aa)
VTNSMB domain-containing protein. (470 aa)
FLNCFilamin C. (2722 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
PXNPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (590 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (767 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1071 aa)
PAK1Non-specific serine/threonine protein kinase. (551 aa)
IGF1RTyrosine-protein kinase receptor. (1369 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
DROSHADrosha ribonuclease III. (1368 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
STAT3Signal transducer and activator of transcription. (771 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (106 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (331 aa)
CTSVCathepsin V; Belongs to the peptidase C1 family. (334 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (580 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
ROCK1Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1353 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (368 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (404 aa)
FLNAFilamin A. (2523 aa)
SDC2Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (201 aa)
ERBB4Receptor protein-tyrosine kinase. (1282 aa)
CTTNCortactin. (544 aa)
VAV1Uncharacterized protein. (671 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1182 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CBLCbl proto-oncogene. (847 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1546 aa)
ITGAVIntegrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (576 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
TWIST1Twist family bHLH transcription factor 1. (133 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (493 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
MAPK1Mitogen-activated protein kinase. (320 aa)
RDXRadixin. (583 aa)
CAMK2DProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (499 aa)
ANK2Ankyrin 2. (3427 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
GRB2Growth factor receptor bound protein 2. (192 aa)
EZREzrin. (579 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2544 aa)
PLCG1Phosphoinositide phospholipase C. (1294 aa)
GAB1GRB2 associated binding protein 1. (724 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1314 aa)
ERBB2Receptor protein-tyrosine kinase. (1263 aa)
HRASHRas proto-oncogene, GTPase. (253 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (816 aa)
PIK3R2Uncharacterized protein. (716 aa)
ESR1Estrogen receptor 1. (449 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (462 aa)
HBEGFHeparin binding EGF like growth factor. (201 aa)
VAV2Vav guanine nucleotide exchange factor 2. (834 aa)
RPS6KB1Ribosomal protein S6 kinase B1. (525 aa)
LOC100476216Uncharacterized protein; Belongs to the peptidase C1 family. (341 aa)
LOC100476469Uncharacterized protein; Belongs to the peptidase C1 family. (333 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (378 aa)
CTNNB1Catenin beta 1. (781 aa)
PTCH1Patched 1. (1438 aa)
CD63Tetraspanin. (216 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (666 aa)
FRS2Fibroblast growth factor receptor substrate 2. (507 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
FLNBFilamin B. (2604 aa)
COL1A1Collagen type I alpha 1 chain. (1464 aa)
EIF4BEukaryotic translation initiation factor 4B. (611 aa)
SRCTyrosine-protein kinase. (542 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (154 aa)
RHOARas homolog family member A. (193 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MMP9Matrix metallopeptidase 9. (705 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (611 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (343 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1029 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
PLCE1Phosphoinositide phospholipase C. (2303 aa)
PIK3R3Uncharacterized protein. (507 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (613 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (322 aa)
RRASRAS related. (180 aa)
ZNF774Zinc finger protein 774. (483 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (661 aa)
HSPG2Heparan sulfate proteoglycan 2. (4396 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
LUMLumican. (338 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (452 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (790 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (482 aa)
TIAM1Uncharacterized protein. (829 aa)
MAPK3Mitogen-activated protein kinase. (351 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (277 aa)
FGFR1Fibroblast growth factor receptor. (822 aa)
PDCD4Programmed cell death 4. (470 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
ACTG1Actin gamma 1; Belongs to the actin family. (375 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2695 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
TIMP3TIMP metallopeptidase inhibitor 3. (211 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
MMP2Matrix metallopeptidase 2. (651 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
LOC100471152Uncharacterized protein. (481 aa)
PLAUPlasminogen activator, urokinase; Belongs to the peptidase S1 family. (432 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
NANOGHomeobox domain-containing protein. (306 aa)
NRASNRAS proto-oncogene, GTPase. (193 aa)
THBS1Thrombospondin 1. (1182 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (96 aa)
COL1A2Collagen type I alpha 2 chain. (1437 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (558 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1420 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (781 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (525 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (572 aa)
TWIST2Twist family bHLH transcription factor 2. (160 aa)
Your Current Organism:
Ailuropoda melanoleuca
NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda
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