Your Input: | |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1867 aa) |
| | CDKN1A | Cyclin dependent kinase inhibitor 1A. (167 aa) |
| | PTEN | Phosphatase and tensin homolog. (403 aa) |
| | TP63 | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa) |
| | ITGA5 | Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1052 aa) |
| | ABCB1 | ATP binding cassette subfamily B member 1. (1280 aa) |
| | MDM4 | Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (492 aa) |
| | EFNA5 | Ephrin A5; Belongs to the ephrin family. (193 aa) |
| | MET | MET proto-oncogene, receptor tyrosine kinase. (1400 aa) |
| | BAK1 | BCL2 antagonist/killer 1. (216 aa) |
| | CDC25A | Cell division cycle 25A. (527 aa) |
| | HMOX1 | Heme oxygenase 1. (288 aa) |
| | SHC4 | SHC adaptor protein 4. (630 aa) |
| | SLC45A3 | Solute carrier family 45 member 3. (552 aa) |
| | HOXD10 | Homeobox D10. (340 aa) |
| | MAP2K2 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa) |
| | ST14 | Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Belongs to the peptidase S1 family. (830 aa) |
| | NOTCH3 | Notch receptor 3. (2204 aa) |
| | TRIM71 | Tripartite motif containing 71. (603 aa) |
| | DNMT3A | DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (912 aa) |
| | SPRY2 | Sprouty RTK signaling antagonist 2. (343 aa) |
| | NOTCH4 | Notch receptor 4. (1998 aa) |
| | EZH2 | Enhancer of zeste 2 polycomb repressive complex 2 subunit. (751 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (733 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | ERBB3 | Erb-b2 receptor tyrosine kinase 3. (1339 aa) |
| | HNRNPK | Heterogeneous nuclear ribonucleoprotein K. (464 aa) |
| | GLS2 | Glutaminase 2. (602 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1034 aa) |
| | WNT3 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa) |
| | PRKCG | Protein kinase C gamma; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (697 aa) |
| | MAPK7 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (807 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (668 aa) |
| | BCL2L11 | Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (196 aa) |
| | PDGFRB | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1102 aa) |
| | IGF2BP1 | Insulin like growth factor 2 mRNA binding protein 1. (597 aa) |
| | CCNG1 | Cyclin G1; Belongs to the cyclin family. (295 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1071 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (755 aa) |
| | CCNE2 | Cyclin E2; Belongs to the cyclin family. (404 aa) |
| | ZFPM2 | Zinc finger protein, FOG family member 2. (1137 aa) |
| | PRKCE | Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa) |
| | BMI1 | RING-type domain-containing protein. (326 aa) |
| | STAT3 | Signal transducer and activator of transcription. (771 aa) |
| | SERPINB5 | Serpin family B member 5; Belongs to the serpin family. (375 aa) |
| | DICER1 | Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1922 aa) |
| | FSCN1 | Fascin. (485 aa) |
| | ROCK1 | Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1353 aa) |
| | TPM1 | Uncharacterized protein; Belongs to the tropomyosin family. (326 aa) |
| | KRAS | KRAS proto-oncogene, GTPase. (189 aa) |
| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (485 aa) |
| | UBE2I | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (158 aa) |
| | CRK | CRK proto-oncogene, adaptor protein. (303 aa) |
| | CASP3 | Caspase 3; Belongs to the peptidase C14A family. (277 aa) |
| | MDM2 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (493 aa) |
| | CRKL | CRK like proto-oncogene, adaptor protein. (303 aa) |
| | MAPK1 | Mitogen-activated protein kinase. (320 aa) |
| | SLC7A1 | Solute carrier family 7 member 1. (629 aa) |
| | NFKB1 | Uncharacterized protein. (781 aa) |
| | RDX | Radixin. (583 aa) |
| | ABCC1 | ATP binding cassette subfamily C member 1. (1527 aa) |
| | GRB2 | Growth factor receptor bound protein 2. (192 aa) |
| | ZEB2 | Zinc finger E-box binding homeobox 2. (1214 aa) |
| | EZR | Ezrin. (579 aa) |
| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2544 aa) |
| | PLCG1 | Phosphoinositide phospholipase C. (1294 aa) |
| | E2F2 | E2F transcription factor 2. (440 aa) |
| | CCNE1 | Cyclin E1; Belongs to the cyclin family. (410 aa) |
| | SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1314 aa) |
| | RECK | Reversion inducing cysteine rich protein with kazal motifs. (971 aa) |
| | ERBB2 | Receptor protein-tyrosine kinase. (1263 aa) |
| | ZEB1 | Zinc finger E-box binding homeobox 1. (1105 aa) |
| | STMN1 | Stathmin; Belongs to the stathmin family. (148 aa) |
| | HRAS | HRas proto-oncogene, GTPase. (253 aa) |
| | VIM | Vimentin; Belongs to the intermediate filament family. (486 aa) |
| | CDKN1B | Cyclin dependent kinase inhibitor 1B. (200 aa) |
| | CDC25B | Cell division cycle 25B. (601 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa) |
| | PDGFB | Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (239 aa) |
| | CREBBP | CREB binding protein. (2370 aa) |
| | PIK3R2 | Uncharacterized protein. (716 aa) |
| | EFNA1 | Ephrin A1; Belongs to the ephrin family. (205 aa) |
| | EFNA3 | Ephrin RBD domain-containing protein; Belongs to the ephrin family. (238 aa) |
| | EFNA4 | Ephrin A4; Belongs to the ephrin family. (204 aa) |
| | HDAC4 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1087 aa) |
| | SHC1 | SHC adaptor protein 1. (587 aa) |
| | RASSF1 | Ras association domain family member 1. (302 aa) |
| | PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (666 aa) |
| | DNMT1 | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1614 aa) |
| | TNC | Tenascin C. (2201 aa) |
| | RHOA | Ras homolog family member A. (193 aa) |
| | APC | APC regulator of WNT signaling pathway. (2848 aa) |
| | MMP9 | Matrix metallopeptidase 9. (705 aa) |
| | BMPR2 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1040 aa) |
| | CYP24A1 | Cytochrome P450 family 24 subfamily A member 1; Belongs to the cytochrome P450 family. (514 aa) |
| | HDAC2 | Histone deacetylase 2. (578 aa) |
| | DNMT3B | DNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (859 aa) |
| | PIK3R3 | Uncharacterized protein. (507 aa) |
| | EP300 | E1A binding protein p300. (2421 aa) |
| | GLS | Glutaminase. (673 aa) |
| | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa) |
| | PRKCB | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (661 aa) |
| | KIF23 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (955 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (452 aa) |
| | ITGB3 | Integrin beta; Belongs to the integrin beta chain family. (790 aa) |
| | FOXP1 | Fork-head domain-containing protein. (679 aa) |
| | MAPK3 | Mitogen-activated protein kinase. (351 aa) |
| | RPTOR | Regulatory associated protein of MTOR complex 1. (1335 aa) |
| | PIM1 | Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (392 aa) |
| | PTGS2 | Prostaglandin-endoperoxide synthase 2. (604 aa) |
| | PDCD4 | Programmed cell death 4. (470 aa) |
| | CCND2 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (291 aa) |
| | FZD3 | Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa) |
| | TIMP3 | TIMP metallopeptidase inhibitor 3. (211 aa) |
| | ABL1 | Tyrosine-protein kinase. (1150 aa) |
| | WNT3A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa) |
| | CDC25C | Cell division cycle 25C. (497 aa) |
| | PLAU | Plasminogen activator, urokinase; Belongs to the peptidase S1 family. (432 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3058 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa) |
| | NRAS | NRAS proto-oncogene, GTPase. (193 aa) |
| | BMF | Bcl2 modifying factor. (184 aa) |
| | THBS1 | Thrombospondin 1. (1182 aa) |
| | DDIT4 | DNA damage inducible transcript 4. (231 aa) |
| | CYP1B1 | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (539 aa) |
| | NOTCH2 | Notch receptor 2. (2447 aa) |
| | G1MH73_AILME | Uncharacterized protein. (408 aa) |
| | CDK6 | Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa) |
| | E2F3 | E2F transcription factor 3. (335 aa) |
| | SIRT1 | Sirtuin 1. (607 aa) |
| | HDAC5 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1111 aa) |
| | PDGFRA | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa) |
| | CDKN2A | Cyclin dependent kinase inhibitor 2A. (103 aa) |
