(51 nodes) Endometrial cancer network (Ailuropoda melanoleuca)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CDKN1A	Cyclin dependent kinase inhibitor 1A. (167 aa)
	PTEN	Phosphatase and tensin homolog. (403 aa)
	POLK	DNA polymerase kappa. (871 aa)
	BAK1	BCL2 antagonist/killer 1. (216 aa)
	G1L3R6_AILME	Uncharacterized protein. (478 aa)
	LEF1	Lymphoid enhancer binding factor 1. (399 aa)
	TCF7L1	Transcription factor 7 like 1. (578 aa)
	MAP2K2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (733 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1034 aa)
	GADD45A	Growth arrest and DNA damage inducible alpha. (165 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1071 aa)
	GADD45B	Growth arrest and DNA damage inducible beta. (155 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
	AXIN1	Axin 1. (866 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	CDH1	Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (883 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	FOXO3	Forkhead box O3. (534 aa)
	MAPK1	Mitogen-activated protein kinase. (320 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	GRB2	Growth factor receptor bound protein 2. (192 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1314 aa)
	ERBB2	Receptor protein-tyrosine kinase. (1263 aa)
	HRAS	HRas proto-oncogene, GTPase. (253 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
	PANDA_007547	Uncharacterized protein. (78 aa)
	PIK3R2	Uncharacterized protein. (716 aa)
	PANDA_019313	Uncharacterized protein. (188 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	AXIN2	Axin 2. (841 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (451 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
	APC	APC regulator of WNT signaling pathway. (2848 aa)
	ARAF	A-Raf proto-oncogene, serine/threonine kinase. (611 aa)
	PIK3R3	Uncharacterized protein. (507 aa)
	BAX	BCL2 associated X, apoptosis regulator. (192 aa)
	MYC	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (452 aa)
	EGF	Epidermal growth factor. (864 aa)
	MAPK3	Mitogen-activated protein kinase. (351 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
	ILK	Integrin linked kinase. (452 aa)
	CTNNA1	Catenin alpha 1. (812 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
	NRAS	NRAS proto-oncogene, GTPase. (193 aa)
	MLH1	MutL homolog 1. (757 aa)
	BAD	BCL2 associated agonist of cell death. (210 aa)
	PDPK1	3-phosphoinositide dependent protein kinase 1. (558 aa)
	CTNNA3	Uncharacterized protein. (193 aa)

Your Current Organism:

Ailuropoda melanoleuca

NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	AKT2	ENSAMEP00000008312	ENSAMEP00000013269	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.900
AKT1	AKT3	ENSAMEP00000008312	ENSAMEP00000009796	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.916
AKT1	BAD	ENSAMEP00000008312	ENSAMEP00000019002	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	BCL2 associated agonist of cell death.	0.950
AKT1	CASP9	ENSAMEP00000008312	ENSAMEP00000012551	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Caspase 9; Belongs to the peptidase C14A family.	0.955
AKT1	CDKN1A	ENSAMEP00000008312	ENSAMEP00000000279	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cyclin dependent kinase inhibitor 1A.	0.958
AKT1	CTNNB1	ENSAMEP00000008312	ENSAMEP00000012247	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Catenin beta 1.	0.627
AKT1	FOXO3	ENSAMEP00000008312	ENSAMEP00000008579	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Forkhead box O3.	0.966
AKT1	GSK3B	ENSAMEP00000008312	ENSAMEP00000007366	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	0.958
AKT1	ILK	ENSAMEP00000008312	ENSAMEP00000017214	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Integrin linked kinase.	0.942
AKT1	MAPK1	ENSAMEP00000008312	ENSAMEP00000009359	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase.	0.926
AKT1	MAPK3	ENSAMEP00000008312	ENSAMEP00000016134	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase.	0.928
AKT1	PDPK1	ENSAMEP00000008312	ENSAMEP00000019008	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	3-phosphoinositide dependent protein kinase 1.	0.986
AKT1	PIK3CA	ENSAMEP00000008312	ENSAMEP00000011350	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.961
AKT1	PIK3CB	ENSAMEP00000008312	ENSAMEP00000005584	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.955
AKT1	PIK3CD	ENSAMEP00000008312	ENSAMEP00000004315	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.950
AKT1	PIK3R1	ENSAMEP00000008312	ENSAMEP00000003218	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphoinositide-3-kinase regulatory subunit 1.	0.958
AKT1	PIK3R2	ENSAMEP00000008312	ENSAMEP00000011630	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.950
AKT1	PIK3R3	ENSAMEP00000008312	ENSAMEP00000014545	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.945
AKT1	PTEN	ENSAMEP00000008312	ENSAMEP00000000745	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatase and tensin homolog.	0.616
AKT1	RAF1	ENSAMEP00000008312	ENSAMEP00000004971	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Raf-1 proto-oncogene, serine/threonine kinase.	0.930