(27 nodes) Primary immunodeficiency network (Ailuropoda melanoleuca)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IKBKG	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (423 aa)
	RFX5	Regulatory factor X5. (619 aa)
	TAP1	Transporter 1, ATP binding cassette subfamily B member. (811 aa)
	TAP2	Uncharacterized protein. (768 aa)
	IL7R	Interleukin 7 receptor. (429 aa)
	CD40LG	CD40 ligand; Belongs to the tumor necrosis factor family. (260 aa)
	ICOS	Inducible T cell costimulator. (209 aa)
	ADA	Adenosine deaminase. (363 aa)
	CD79A	CD79a molecule. (231 aa)
	ZAP70	Tyrosine-protein kinase. (613 aa)
	AICDA	Activation induced cytidine deaminase. (198 aa)
	BTK	Tyrosine-protein kinase. (659 aa)
	CD8A	CD8a molecule. (268 aa)
	CD8B	Ig-like domain-containing protein. (205 aa)
	JAK3	Tyrosine-protein kinase. (1104 aa)
	DCLRE1C	DNA cross-link repair 1C. (692 aa)
	RFXANK	Regulatory factor X associated ankyrin containing protein. (260 aa)
	TNFRSF13B	TNF receptor superfamily member 13B. (268 aa)
	CD40	CD40 molecule. (289 aa)
	CD3D	CD3d molecule. (180 aa)
	CD4	Ig-like domain-containing protein. (412 aa)
	ORAI1	ORAI calcium release-activated calcium modulator 1. (301 aa)
	RFXAP	Regulatory factor X associated protein. (282 aa)
	CD19	CD19 molecule. (553 aa)
	IL2RG	Fibronectin type-III domain-containing protein. (374 aa)
	RAG1	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1043 aa)
	RAG2	Recombination activating 2. (527 aa)

Your Current Organism:

Ailuropoda melanoleuca

NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADA	CD4	ENSAMEP00000004276	ENSAMEP00000014814	Adenosine deaminase.	Ig-like domain-containing protein.	0.462
AICDA	CD19	ENSAMEP00000007460	ENSAMEP00000016558	Activation induced cytidine deaminase.	CD19 molecule.	0.620
AICDA	CD4	ENSAMEP00000007460	ENSAMEP00000014814	Activation induced cytidine deaminase.	Ig-like domain-containing protein.	0.759
AICDA	CD40	ENSAMEP00000007460	ENSAMEP00000013591	Activation induced cytidine deaminase.	CD40 molecule.	0.762
AICDA	CD40LG	ENSAMEP00000007460	ENSAMEP00000003046	Activation induced cytidine deaminase.	CD40 ligand; Belongs to the tumor necrosis factor family.	0.749
AICDA	RAG1	ENSAMEP00000007460	ENSAMEP00000020436	Activation induced cytidine deaminase.	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...]	0.495
AICDA	RAG2	ENSAMEP00000007460	ENSAMEP00000020459	Activation induced cytidine deaminase.	Recombination activating 2.	0.455
BTK	CD19	ENSAMEP00000009855	ENSAMEP00000016558	Tyrosine-protein kinase.	CD19 molecule.	0.645
BTK	CD3D	ENSAMEP00000009855	ENSAMEP00000013860	Tyrosine-protein kinase.	CD3d molecule.	0.446
BTK	CD4	ENSAMEP00000009855	ENSAMEP00000014814	Tyrosine-protein kinase.	Ig-like domain-containing protein.	0.601
BTK	CD40	ENSAMEP00000009855	ENSAMEP00000013591	Tyrosine-protein kinase.	CD40 molecule.	0.495
BTK	CD40LG	ENSAMEP00000009855	ENSAMEP00000003046	Tyrosine-protein kinase.	CD40 ligand; Belongs to the tumor necrosis factor family.	0.492
BTK	CD79A	ENSAMEP00000009855	ENSAMEP00000004725	Tyrosine-protein kinase.	CD79a molecule.	0.703
BTK	IKBKG	ENSAMEP00000009855	ENSAMEP00000000435	Tyrosine-protein kinase.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.923
BTK	IL7R	ENSAMEP00000009855	ENSAMEP00000002681	Tyrosine-protein kinase.	Interleukin 7 receptor.	0.434
BTK	RAG2	ENSAMEP00000009855	ENSAMEP00000020459	Tyrosine-protein kinase.	Recombination activating 2.	0.519
BTK	ZAP70	ENSAMEP00000009855	ENSAMEP00000005498	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.639
CD19	AICDA	ENSAMEP00000016558	ENSAMEP00000007460	CD19 molecule.	Activation induced cytidine deaminase.	0.620
CD19	BTK	ENSAMEP00000016558	ENSAMEP00000009855	CD19 molecule.	Tyrosine-protein kinase.	0.645
CD19	CD4	ENSAMEP00000016558	ENSAMEP00000014814	CD19 molecule.	Ig-like domain-containing protein.	0.962