STRINGSTRING
BMPR2 BMPR2 FLT4 FLT4 EDN1 EDN1 ITGA10 ITGA10 LIPG LIPG VEGFD VEGFD GOLGA3 GOLGA3 ZRANB1 ZRANB1 M3XV15_MUSPF M3XV15_MUSPF LOC106003337 LOC106003337 FADD FADD CDH5 CDH5 CXCR3 CXCR3 CSDE1 CSDE1 M3Y3I1_MUSPF M3Y3I1_MUSPF NPHS1 NPHS1 APOE APOE HHIP HHIP ICAM1 ICAM1 CLEC4G CLEC4G ARHGEF38 ARHGEF38 M3YCN1_MUSPF M3YCN1_MUSPF P4HA3 P4HA3 DNAJC13 DNAJC13 ARNTL2 ARNTL2 ASGR1 ASGR1 IL1B IL1B JUP JUP RIPK2 RIPK2 TJP1 TJP1 EFNB2 EFNB2 LAMC1 LAMC1 STAB2 STAB2 VCAM1 VCAM1 VEGFC VEGFC PDSS1 PDSS1 VEGFA VEGFA LYVE1 LYVE1 IL6 IL6 TIE1 TIE1 NTAN1 NTAN1 CCR7 CCR7 TNS4 TNS4 M3YTG0_MUSPF M3YTG0_MUSPF PECAM1 PECAM1 ERN1 ERN1 DGKE DGKE SELL SELL SELE SELE EPHB4 EPHB4 PDPN PDPN FAM124B FAM124B VWF VWF ENTPD1 ENTPD1 SKIL SKIL CSGALNACT2 CSGALNACT2 SDC4 SDC4 RXFP1 RXFP1 CHST1 CHST1 THBD THBD CLDN5 CLDN5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1045 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1355 aa)
EDN1Endothelin 1. (202 aa)
ITGA10Integrin subunit alpha 10; Belongs to the integrin alpha chain family. (1167 aa)
LIPGLipase G, endothelial type. (500 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
GOLGA3Golgin A3. (1528 aa)
ZRANB1Zinc finger RANBP2-type containing 1. (737 aa)
M3XV15_MUSPFTACC_C domain-containing protein. (944 aa)
LOC106003337Uncharacterized protein. (1924 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (216 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (783 aa)
CXCR3C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (368 aa)
CSDE1Cold shock domain containing E1. (784 aa)
M3Y3I1_MUSPFCyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. (488 aa)
NPHS1NPHS1 adhesion molecule, nephrin. (1242 aa)
APOEApolipoprotein E. (322 aa)
HHIPHedgehog interacting protein. (700 aa)
ICAM1Intercellular adhesion molecule 1. (589 aa)
CLEC4GC-type lectin domain family 4 member G. (317 aa)
ARHGEF38Rho guanine nucleotide exchange factor 38. (671 aa)
M3YCN1_MUSPFUncharacterized protein. (223 aa)
P4HA3Prolyl 4-hydroxylase subunit alpha 3. (404 aa)
DNAJC13DnaJ heat shock protein family (Hsp40) member C13. (2248 aa)
ARNTL2Aryl hydrocarbon receptor nuclear translocator like 2. (622 aa)
ASGR1Asialoglycoprotein receptor 1. (290 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (168 aa)
JUPJunction plakoglobin. (744 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
TJP1Tight junction protein 1; Belongs to the MAGUK family. (1770 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (333 aa)
LAMC1Laminin subunit gamma 1. (1573 aa)
STAB2Stabilin 2. (2549 aa)
VCAM1Vascular cell adhesion molecule 1. (739 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (370 aa)
PDSS1Decaprenyl diphosphate synthase subunit 1; Belongs to the FPP/GGPP synthase family. (419 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (398 aa)
LYVE1Lymphatic vessel endothelial hyaluronan receptor 1. (324 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (994 aa)
NTAN1N-terminal asparagine amidase. (284 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (379 aa)
TNS4Tensin 4. (711 aa)
M3YTG0_MUSPFUncharacterized protein. (73 aa)
PECAM1Platelet and endothelial cell adhesion molecule 1. (739 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (975 aa)
DGKEDiacylglycerol kinase. (572 aa)
SELLSelectin L. (388 aa)
SELESelectin E. (609 aa)
EPHB4EPH receptor B4. (987 aa)
PDPNPodoplanin. (177 aa)
FAM124BFamily with sequence similarity 124 member B. (459 aa)
VWFVon Willebrand factor. (2814 aa)
ENTPD1Ectonucleoside triphosphate diphosphohydrolase 1; Belongs to the GDA1/CD39 NTPase family. (510 aa)
SKILSKI like proto-oncogene. (664 aa)
CSGALNACT2Hexosyltransferase. (542 aa)
SDC4Syndecan 4. (200 aa)
RXFP1Relaxin family peptide receptor 1. (758 aa)
CHST1Sulfotransferase; Belongs to the sulfotransferase 1 family. (411 aa)
THBDThrombomodulin. (567 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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