(65 nodes) Mixed, incl. cAMP metabolic process, and Adenylate kinase/UMP-CMP kinase network (Mustela putorius)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	M3XMV4_MUSPF	Uncharacterized protein. (466 aa)
	AK4	Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity. (274 aa)
	M3XNV3_MUSPF	Uncharacterized protein. (93 aa)
	M3XNV5_MUSPF	PDE4_UCR domain-containing protein. (232 aa)
	PDE4B	Phosphodiesterase. (544 aa)
	RAPGEF4	Rap guanine nucleotide exchange factor 4. (1011 aa)
	ADCY8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
	PDE1A	Phosphodiesterase 1A; Belongs to the cyclic nucleotide phosphodiesterase family. (523 aa)
	AK7	Adenylate kinase 7. (722 aa)
	ADCY7	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
	PDE11A	Phosphodiesterase. (934 aa)
	ADK	Adenosine kinase. (362 aa)
	ENTPD4	Ectonucleoside triphosphate diphosphohydrolase 4; Belongs to the GDA1/CD39 NTPase family. (682 aa)
	AMPD2	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (879 aa)
	ADCY5	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1018 aa)
	GNAL	G protein subunit alpha L. (380 aa)
	AK3	GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (227 aa)
	M3Y1M3_MUSPF	Phosphodiesterase. (782 aa)
	NT5E	5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (470 aa)
	PDE1C	Phosphodiesterase. (709 aa)
	NT5C3A	5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (297 aa)
	PDE1B	Phosphodiesterase. (535 aa)
	NTPCR	Nucleoside-triphosphatase, cancer-related. (186 aa)
	ADCY4	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1105 aa)
	AMPD1	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (781 aa)
	PDE10A	Phosphodiesterase. (794 aa)
	THTPA	Thiamine triphosphatase. (230 aa)
	M3Y5C8_MUSPF	Uncharacterized protein; Belongs to the adenylate kinase family. (211 aa)
	PDE4A	Phosphodiesterase. (810 aa)
	TPK1	Thiamine pyrophosphokinase; Belongs to the thiamine pyrophosphokinase family. (243 aa)
	ADCY2	Adenylate cyclase 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (880 aa)
	PDE4D	Phosphodiesterase. (673 aa)
	ENTPD5	Ectonucleoside triphosphate diphosphohydrolase 5 (inactive); Belongs to the GDA1/CD39 NTPase family. (428 aa)
	PDE2A	Phosphodiesterase. (920 aa)
	PDE7A	Phosphodiesterase 7A; Belongs to the cyclic nucleotide phosphodiesterase family. (419 aa)
	AK9	Adenylate kinase 9. (1960 aa)
	ENTPD2	Ectonucleoside triphosphate diphosphohydrolase 2; Belongs to the GDA1/CD39 NTPase family. (495 aa)
	AK5	Adenylate kinase 5; Belongs to the adenylate kinase family. (561 aa)
	PDE3A	Phosphodiesterase. (1137 aa)
	AK2	Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. (249 aa)
	CANT1	Calcium activated nucleotidase 1. (401 aa)
	AK8	Adenylate kinase 8; Belongs to the adenylate kinase family. (479 aa)
	M3YMK1_MUSPF	Protein kinase domain-containing protein. (105 aa)
	AMPD3	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (767 aa)
	PDE3B	Phosphodiesterase. (889 aa)
	AK1	Adenylate kinase 1; Belongs to the adenylate kinase family. (227 aa)
	M3YQF9_MUSPF	Guanylate cyclase domain-containing protein. (1619 aa)
	PTRHD1	Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
	ADCY3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
	ENPP3	Ectonucleotide pyrophosphatase/phosphodiesterase 3. (877 aa)
	ENPP1	Ectonucleotide pyrophosphatase/phosphodiesterase 1. (847 aa)
	ADCY6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
	PDE7B	Phosphodiesterase. (446 aa)
	ADCY9	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
	AK2-2	Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. (241 aa)
	NME1	Nucleoside diphosphate kinase. (168 aa)
	NME2	Nucleoside diphosphate kinase. (182 aa)
	PDE8A	Phosphodiesterase. (773 aa)
	M3YVX3_MUSPF	Phosphodiesterase. (811 aa)
	ENTPD6	Ectonucleoside triphosphate diphosphohydrolase 6; Belongs to the GDA1/CD39 NTPase family. (456 aa)
	ENTPD1	Ectonucleoside triphosphate diphosphohydrolase 1; Belongs to the GDA1/CD39 NTPase family. (510 aa)
	PKM	Pyruvate kinase; Belongs to the pyruvate kinase family. (579 aa)
	PDE5A	Phosphodiesterase. (865 aa)
	ENTPD3	Ectonucleoside triphosphate diphosphohydrolase 3; Belongs to the GDA1/CD39 NTPase family. (484 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1130 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY2	ENSMPUP00000018070	ENSMPUP00000007102	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.572
ADCY1	ADCY3	ENSMPUP00000018070	ENSMPUP00000013920	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.833
ADCY1	ADCY4	ENSMPUP00000018070	ENSMPUP00000005626	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.564
ADCY1	ADCY5	ENSMPUP00000018070	ENSMPUP00000004470	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.548
ADCY1	ADCY6	ENSMPUP00000018070	ENSMPUP00000014639	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.550
ADCY1	ADCY7	ENSMPUP00000018070	ENSMPUP00000003122	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.655
ADCY1	ADCY8	ENSMPUP00000018070	ENSMPUP00000001384	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.855
ADCY1	ADCY9	ENSMPUP00000018070	ENSMPUP00000014921	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.620
ADCY1	AK9	ENSMPUP00000018070	ENSMPUP00000009965	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate kinase 9.	0.846
ADCY1	ENPP1	ENSMPUP00000018070	ENSMPUP00000014565	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Ectonucleotide pyrophosphatase/phosphodiesterase 1.	0.851
ADCY1	ENPP3	ENSMPUP00000018070	ENSMPUP00000014562	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Ectonucleotide pyrophosphatase/phosphodiesterase 3.	0.866
ADCY1	ENTPD1	ENSMPUP00000018070	ENSMPUP00000016993	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Ectonucleoside triphosphate diphosphohydrolase 1; Belongs to the GDA1/CD39 NTPase family.	0.856
ADCY1	ENTPD2	ENSMPUP00000018070	ENSMPUP00000010678	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Ectonucleoside triphosphate diphosphohydrolase 2; Belongs to the GDA1/CD39 NTPase family.	0.855
ADCY1	ENTPD3	ENSMPUP00000018070	ENSMPUP00000017848	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Ectonucleoside triphosphate diphosphohydrolase 3; Belongs to the GDA1/CD39 NTPase family.	0.855
ADCY1	GNAL	ENSMPUP00000018070	ENSMPUP00000004509	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha L.	0.905
ADCY1	M3XMV4_MUSPF	ENSMPUP00000018070	ENSMPUP00000000404	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.874
ADCY1	M3XNV3_MUSPF	ENSMPUP00000018070	ENSMPUP00000000753	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.811
ADCY1	M3XNV5_MUSPF	ENSMPUP00000018070	ENSMPUP00000000755	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	PDE4_UCR domain-containing protein.	0.811
ADCY1	M3Y1M3_MUSPF	ENSMPUP00000018070	ENSMPUP00000005224	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.847
ADCY1	M3YMK1_MUSPF	ENSMPUP00000018070	ENSMPUP00000012558	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase domain-containing protein.	0.836