(68 nodes) Mixed, incl. Toll-like receptor signaling pathway, and NIK/NF-kappaB signaling network (Mustela putorius)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IRAK4	Interleukin-1 receptor-associated kinase 4. (460 aa)
	TANK	TRAF family member associated NFKB activator. (446 aa)
	LY86	Lymphocyte antigen 86. (119 aa)
	M3XP56_MUSPF	Protein kinase domain-containing protein. (158 aa)
	M3XP59_MUSPF	SAM domain-containing protein. (355 aa)
	TNFSF15	TNF superfamily member 15. (255 aa)
	TLR4	Toll like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
	TLR7	Toll like receptor 7; Belongs to the Toll-like receptor family. (1083 aa)
	TAB3	TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (715 aa)
	TLR8	Toll like receptor 8; Belongs to the Toll-like receptor family. (1087 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
	LZTR1	Leucine zipper like transcription regulator 1. (840 aa)
	UNC93B1	Unc-93 homolog B1, TLR signaling regulator. (533 aa)
	REL	REL proto-oncogene, NF-kB subunit. (594 aa)
	TICAM1	TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (689 aa)
	TRADD	TNFRSF1A associated via death domain. (314 aa)
	IRF5	Interferon regulatory factor 5. (504 aa)
	BCL3	BCL3 transcription coactivator. (456 aa)
	TIRAP	TIR domain containing adaptor protein. (227 aa)
	PLEKHG5	Pleckstrin homology and RhoGEF domain containing G5. (1036 aa)
	M3Y5Z5_MUSPF	TNFR-Cys domain-containing protein. (313 aa)
	M3Y6K2_MUSPF	Uncharacterized protein. (516 aa)
	M3Y7T9_MUSPF	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
	TRAF1	TNF receptor-associated factor. (415 aa)
	M3YA16_MUSPF	Uncharacterized protein. (600 aa)
	CD14	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (371 aa)
	MAP3K14	Mitogen-activated protein kinase kinase kinase 14. (954 aa)
	MAVS	Mitochondrial antiviral signaling protein. (524 aa)
	IRAK1	Interleukin 1 receptor associated kinase 1. (696 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (971 aa)
	LY96	Lymphocyte antigen 96. (160 aa)
	TNIP2	TNFAIP3 interacting protein 2. (435 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (764 aa)
	LTB	Lymphotoxin beta; Belongs to the tumor necrosis factor family. (247 aa)
	TNF	Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family. (233 aa)
	LTA	Lymphotoxin alpha; Belongs to the tumor necrosis factor family. (204 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (511 aa)
	M3YJV8_MUSPF	Uncharacterized protein. (1327 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
	NFKBIZ	NFKB inhibitor zeta. (720 aa)
	IKBKE	Inhibitor of nuclear factor kappa B kinase subunit epsilon. (719 aa)
	NFKBIE	NFKB inhibitor epsilon. (394 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
	TAB1	TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
	TNIP1	TNFAIP3 interacting protein 1. (635 aa)
	TRAF4	TNF receptor-associated factor. (470 aa)
	CD180	CD180 molecule. (662 aa)
	TNFAIP3	TNF alpha induced protein 3. (790 aa)
	TRAF5	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
	NFKBIA	NFKB inhibitor alpha. (314 aa)
	TNFRSF1B	TNF receptor superfamily member 1B. (509 aa)
	MAP3K8	Mitogen-activated protein kinase kinase kinase 8. (467 aa)
	NFKB2	Nuclear factor kappa B subunit 2. (900 aa)
	LTBR	Lymphotoxin beta receptor. (420 aa)
	TNFRSF1A	TNF receptor superfamily member 1A. (501 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
	IRAK2	Interleukin 1 receptor associated kinase 2. (580 aa)
	TBK1	TANK-binding kinase 1. (729 aa)
	NFKBIB	NFKB inhibitor beta. (354 aa)
	TAB2	TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
	ENSMPUP00000018236	annotation not available (152 aa)
	TLR5	Toll like receptor 5; Belongs to the Toll-like receptor family. (858 aa)
	TLR2	Toll like receptor 2; Belongs to the Toll-like receptor family. (785 aa)
	TLR1	Toll like receptor 1; Belongs to the Toll-like receptor family. (786 aa)
	TLR6	Toll like receptor 6; Belongs to the Toll-like receptor family. (793 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL3	CHUK	ENSMPUP00000006272	ENSMPUP00000016874	BCL3 transcription coactivator.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.583
BCL3	IKBKB	ENSMPUP00000006272	ENSMPUP00000012607	BCL3 transcription coactivator.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.598
BCL3	IRAK4	ENSMPUP00000006272	ENSMPUP00000000358	BCL3 transcription coactivator.	Interleukin-1 receptor-associated kinase 4.	0.407
BCL3	MAP3K8	ENSMPUP00000006272	ENSMPUP00000016311	BCL3 transcription coactivator.	Mitogen-activated protein kinase kinase kinase 8.	0.591
BCL3	MYD88	ENSMPUP00000006272	ENSMPUP00000002726	BCL3 transcription coactivator.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.401
BCL3	NFKB1	ENSMPUP00000006272	ENSMPUP00000009338	BCL3 transcription coactivator.	Nuclear factor kappa B subunit 1.	0.949
BCL3	NFKB2	ENSMPUP00000006272	ENSMPUP00000016777	BCL3 transcription coactivator.	Nuclear factor kappa B subunit 2.	0.821
BCL3	NFKBIB	ENSMPUP00000006272	ENSMPUP00000017640	BCL3 transcription coactivator.	NFKB inhibitor beta.	0.492
BCL3	NFKBIZ	ENSMPUP00000006272	ENSMPUP00000011692	BCL3 transcription coactivator.	NFKB inhibitor zeta.	0.406
BCL3	REL	ENSMPUP00000006272	ENSMPUP00000005142	BCL3 transcription coactivator.	REL proto-oncogene, NF-kB subunit.	0.718
BCL3	RELA	ENSMPUP00000006272	ENSMPUP00000011545	BCL3 transcription coactivator.	RELA proto-oncogene, NF-kB subunit.	0.711
BCL3	TLR5	ENSMPUP00000006272	ENSMPUP00000018636	BCL3 transcription coactivator.	Toll like receptor 5; Belongs to the Toll-like receptor family.	0.400
BCL3	TNIP2	ENSMPUP00000006272	ENSMPUP00000010859	BCL3 transcription coactivator.	TNFAIP3 interacting protein 2.	0.471
CD14	LY96	ENSMPUP00000008395	ENSMPUP00000010107	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	Lymphocyte antigen 96.	0.981
CD14	M3YJV8_MUSPF	ENSMPUP00000008395	ENSMPUP00000011615	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	Uncharacterized protein.	0.462
CD14	TLR1	ENSMPUP00000008395	ENSMPUP00000020020	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	Toll like receptor 1; Belongs to the Toll-like receptor family.	0.499
CD14	TLR2	ENSMPUP00000008395	ENSMPUP00000018774	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	Toll like receptor 2; Belongs to the Toll-like receptor family.	0.957
CD14	TLR3	ENSMPUP00000008395	ENSMPUP00000011144	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.531
CD14	TLR4	ENSMPUP00000008395	ENSMPUP00000001697	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	Toll like receptor 4; Belongs to the Toll-like receptor family.	0.977
CD14	TLR5	ENSMPUP00000008395	ENSMPUP00000018636	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	Toll like receptor 5; Belongs to the Toll-like receptor family.	0.402