(21 nodes) Mixed, incl. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation, and TNF receptor-associated factor TRAF, metazoa network (Mustela putorius)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IRAK4	Interleukin-1 receptor-associated kinase 4. (460 aa)
	TANK	TRAF family member associated NFKB activator. (446 aa)
	TAB3	TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (715 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
	TICAM1	TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (689 aa)
	TRADD	TNFRSF1A associated via death domain. (314 aa)
	TRAF1	TNF receptor-associated factor. (415 aa)
	MAVS	Mitochondrial antiviral signaling protein. (524 aa)
	IRAK1	Interleukin 1 receptor associated kinase 1. (696 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (764 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
	IKBKE	Inhibitor of nuclear factor kappa B kinase subunit epsilon. (719 aa)
	TAB1	TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
	TRAF5	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
	TNFRSF1A	TNF receptor superfamily member 1A. (501 aa)
	IRAK2	Interleukin 1 receptor associated kinase 2. (580 aa)
	TBK1	TANK-binding kinase 1. (729 aa)
	TAB2	TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IKBKE	MAVS	ENSMPUP00000011981	ENSMPUP00000008630	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	Mitochondrial antiviral signaling protein.	0.953
IKBKE	MYD88	ENSMPUP00000011981	ENSMPUP00000002726	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.579
IKBKE	TAB2	ENSMPUP00000011981	ENSMPUP00000017956	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	TGF-beta activated kinase 1 (MAP3K7) binding protein 2.	0.524
IKBKE	TAB3	ENSMPUP00000011981	ENSMPUP00000002537	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	TGF-beta activated kinase 1 (MAP3K7) binding protein 3.	0.491
IKBKE	TANK	ENSMPUP00000011981	ENSMPUP00000000539	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	TRAF family member associated NFKB activator.	0.986
IKBKE	TBK1	ENSMPUP00000011981	ENSMPUP00000017416	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	TANK-binding kinase 1.	0.994
IKBKE	TICAM1	ENSMPUP00000011981	ENSMPUP00000005217	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines.	0.531
IKBKE	TLR3	ENSMPUP00000011981	ENSMPUP00000011144	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.545
IKBKE	TNFRSF1A	ENSMPUP00000011981	ENSMPUP00000016811	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	TNF receptor superfamily member 1A.	0.948
IKBKE	TRADD	ENSMPUP00000011981	ENSMPUP00000005348	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	TNFRSF1A associated via death domain.	0.661
IKBKE	TRAF1	ENSMPUP00000011981	ENSMPUP00000007586	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	TNF receptor-associated factor.	0.846
IKBKE	TRAF2	ENSMPUP00000011981	ENSMPUP00000010903	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.889
IKBKE	TRAF3	ENSMPUP00000011981	ENSMPUP00000002600	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.995
IKBKE	TRAF5	ENSMPUP00000011981	ENSMPUP00000015743	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.858
IKBKE	TRAF6	ENSMPUP00000011981	ENSMPUP00000011691	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.955
IRAK1	IRAK2	ENSMPUP00000008986	ENSMPUP00000017048	Interleukin 1 receptor associated kinase 1.	Interleukin 1 receptor associated kinase 2.	0.970
IRAK1	IRAK4	ENSMPUP00000008986	ENSMPUP00000000358	Interleukin 1 receptor associated kinase 1.	Interleukin-1 receptor-associated kinase 4.	0.998
IRAK1	MAP3K7	ENSMPUP00000008986	ENSMPUP00000009014	Interleukin 1 receptor associated kinase 1.	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	0.931
IRAK1	MAVS	ENSMPUP00000008986	ENSMPUP00000008630	Interleukin 1 receptor associated kinase 1.	Mitochondrial antiviral signaling protein.	0.897
IRAK1	MYD88	ENSMPUP00000008986	ENSMPUP00000002726	Interleukin 1 receptor associated kinase 1.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.999