(10 nodes) Mixed, incl. MAP kinase kinase kinase kinase activity, and MLK1-3, SH3 domain network (Mustela putorius)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MAPK8IP2	Mitogen-activated protein kinase 8 interacting protein 2. (832 aa)
	MAPK8IP1	Mitogen-activated protein kinase 8 interacting protein 1. (703 aa)
	TSPAN18	Tetraspanin. (258 aa)
	TMEM52	Transmembrane protein 52. (159 aa)
	MAP2K7	Mitogen-activated protein kinase kinase 7. (461 aa)
	MAP4K3	Mitogen-activated protein kinase kinase kinase kinase 3; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (831 aa)
	MAP3K11	Mitogen-activated protein kinase kinase kinase. (863 aa)
	MAP4K2	Mitogen-activated protein kinase kinase kinase kinase 2; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (847 aa)
	MAP3K10	Mitogen-activated protein kinase kinase kinase. (936 aa)
	MAP4K1	Mitogen-activated protein kinase kinase kinase kinase 1; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (820 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MAP2K7	MAP3K10	ENSMPUP00000007957	ENSMPUP00000017601	Mitogen-activated protein kinase kinase 7.	Mitogen-activated protein kinase kinase kinase.	0.889
MAP2K7	MAP3K11	ENSMPUP00000007957	ENSMPUP00000011738	Mitogen-activated protein kinase kinase 7.	Mitogen-activated protein kinase kinase kinase.	0.944
MAP2K7	MAPK8IP1	ENSMPUP00000007957	ENSMPUP00000005637	Mitogen-activated protein kinase kinase 7.	Mitogen-activated protein kinase 8 interacting protein 1.	0.944
MAP2K7	MAPK8IP2	ENSMPUP00000007957	ENSMPUP00000001935	Mitogen-activated protein kinase kinase 7.	Mitogen-activated protein kinase 8 interacting protein 2.	0.939
MAP3K10	MAP2K7	ENSMPUP00000017601	ENSMPUP00000007957	Mitogen-activated protein kinase kinase kinase.	Mitogen-activated protein kinase kinase 7.	0.889
MAP3K10	MAPK8IP2	ENSMPUP00000017601	ENSMPUP00000001935	Mitogen-activated protein kinase kinase kinase.	Mitogen-activated protein kinase 8 interacting protein 2.	0.540
MAP3K11	MAP2K7	ENSMPUP00000011738	ENSMPUP00000007957	Mitogen-activated protein kinase kinase kinase.	Mitogen-activated protein kinase kinase 7.	0.944
MAP3K11	MAP4K1	ENSMPUP00000011738	ENSMPUP00000017683	Mitogen-activated protein kinase kinase kinase.	Mitogen-activated protein kinase kinase kinase kinase 1; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.	0.910
MAP3K11	MAP4K2	ENSMPUP00000011738	ENSMPUP00000012419	Mitogen-activated protein kinase kinase kinase.	Mitogen-activated protein kinase kinase kinase kinase 2; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.	0.413
MAP3K11	MAPK8IP1	ENSMPUP00000011738	ENSMPUP00000005637	Mitogen-activated protein kinase kinase kinase.	Mitogen-activated protein kinase 8 interacting protein 1.	0.962
MAP3K11	MAPK8IP2	ENSMPUP00000011738	ENSMPUP00000001935	Mitogen-activated protein kinase kinase kinase.	Mitogen-activated protein kinase 8 interacting protein 2.	0.955
MAP4K1	MAP3K11	ENSMPUP00000017683	ENSMPUP00000011738	Mitogen-activated protein kinase kinase kinase kinase 1; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.	Mitogen-activated protein kinase kinase kinase.	0.910
MAP4K1	MAPK8IP1	ENSMPUP00000017683	ENSMPUP00000005637	Mitogen-activated protein kinase kinase kinase kinase 1; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.	Mitogen-activated protein kinase 8 interacting protein 1.	0.895
MAP4K1	MAPK8IP2	ENSMPUP00000017683	ENSMPUP00000001935	Mitogen-activated protein kinase kinase kinase kinase 1; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.	Mitogen-activated protein kinase 8 interacting protein 2.	0.881
MAP4K2	MAP3K11	ENSMPUP00000012419	ENSMPUP00000011738	Mitogen-activated protein kinase kinase kinase kinase 2; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.	Mitogen-activated protein kinase kinase kinase.	0.413
MAP4K2	MAPK8IP1	ENSMPUP00000012419	ENSMPUP00000005637	Mitogen-activated protein kinase kinase kinase kinase 2; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.	Mitogen-activated protein kinase 8 interacting protein 1.	0.493
MAP4K2	MAPK8IP2	ENSMPUP00000012419	ENSMPUP00000001935	Mitogen-activated protein kinase kinase kinase kinase 2; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.	Mitogen-activated protein kinase 8 interacting protein 2.	0.517
MAP4K2	TMEM52	ENSMPUP00000012419	ENSMPUP00000007949	Mitogen-activated protein kinase kinase kinase kinase 2; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.	Transmembrane protein 52.	0.459
MAP4K3	TSPAN18	ENSMPUP00000010447	ENSMPUP00000005980	Mitogen-activated protein kinase kinase kinase kinase 3; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.	Tetraspanin.	0.533
MAPK8IP1	MAP2K7	ENSMPUP00000005637	ENSMPUP00000007957	Mitogen-activated protein kinase 8 interacting protein 1.	Mitogen-activated protein kinase kinase 7.	0.944