STRINGSTRING
SMAD3 SMAD3 SMAD6 SMAD6 BMPR2 BMPR2 ACVR1C ACVR1C ACVR1 ACVR1 BMP6 BMP6 HJV HJV SMAD7 SMAD7 SMAD2 SMAD2 GDF11 GDF11 INHBC INHBC SMAD9 SMAD9 BMPR1B BMPR1B ACVR2B ACVR2B BMP5 BMP5 CHRD CHRD ACVR2A ACVR2A TGFB2 TGFB2 NODAL NODAL ZFYVE16 ZFYVE16 BMP4 BMP4 AMHR2 AMHR2 BMP10 BMP10 BMP2 BMP2 BMP7 BMP7 TGFBR1 TGFBR1 SMAD1 SMAD1 ZFYVE9 ZFYVE9 ACVR1B ACVR1B SKI SKI ACVRL1 ACVRL1 GDF6 GDF6 SMAD4 SMAD4 BMPR1A BMPR1A GDF2 GDF2 SMAD5 SMAD5 GDF9 GDF9 TGFBR2 TGFBR2 MSTN MSTN GDF7 GDF7 BMP15 BMP15 M3YSB8_MUSPF M3YSB8_MUSPF FST FST M3YSK2_MUSPF M3YSK2_MUSPF SMURF2 SMURF2 GREM2 GREM2 SMURF1 SMURF1 INHA INHA SKIL SKIL TGFB1 TGFB1 INHBA INHBA INHBB INHBB NOG NOG GREM1 GREM1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMAD3Mothers against decapentaplegic homolog. (414 aa)
SMAD6Mothers against decapentaplegic homolog. (494 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1045 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
BMP6Bone morphogenetic protein 6. (426 aa)
HJVHemojuvelin BMP co-receptor. (426 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
SMAD2Mothers against decapentaplegic homolog. (495 aa)
GDF11Growth differentiation factor 11. (404 aa)
INHBCInhibin subunit beta C. (353 aa)
SMAD9Mothers against decapentaplegic homolog. (432 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (514 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (484 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
CHRDChordin. (882 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
TGFB2Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (414 aa)
NODALNodal growth differentiation factor. (348 aa)
ZFYVE16Zinc finger FYVE domain-containing protein. (1450 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
AMHR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (585 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (480 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1422 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (494 aa)
SKISKI proto-oncogene. (680 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
GDF6Growth differentiation factor 6. (434 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
GDF2Growth differentiation factor 2. (429 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
GDF9Growth differentiation factor 9. (400 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (445 aa)
MSTNMyostatin. (375 aa)
GDF7Growth differentiation factor 7. (382 aa)
BMP15Bone morphogenetic protein 15. (404 aa)
M3YSB8_MUSPFTGF_BETA_2 domain-containing protein. (351 aa)
FSTFollistatin. (344 aa)
M3YSK2_MUSPFTGF_BETA_2 domain-containing protein. (291 aa)
SMURF2E3 ubiquitin-protein ligase. (739 aa)
GREM2Gremlin. (177 aa)
SMURF1E3 ubiquitin-protein ligase. (725 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (368 aa)
SKILSKI like proto-oncogene. (664 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
INHBAInhibin subunit beta A. (424 aa)
INHBBInhibin subunit beta B. (238 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
GREM1Gremlin. (184 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.