(105 nodes) Complement and coagulation cascades, and Blood coagulation, intrinsic pathway network (Mustela putorius)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SERPING1	Serpin family G member 1; Belongs to the serpin family. (479 aa)
	F13A1	Coagulation factor XIII A chain. (732 aa)
	ABCB11	ATP binding cassette subfamily B member 11. (1325 aa)
	CLU	Clusterin; Belongs to the clusterin family. (462 aa)
	CD93	CD93 molecule. (745 aa)
	M3XQJ0_MUSPF	TED_complement domain-containing protein. (148 aa)
	M3XQJ3_MUSPF	A2M_recep domain-containing protein. (267 aa)
	SPHKAP	SPHK1 interactor, AKAP domain containing. (1591 aa)
	M3XRA2_MUSPF	Lipocln_cytosolic_FA-bd_dom domain-containing protein. (156 aa)
	F9	Coagulation factor IX. (459 aa)
	SPP2	Secreted phosphoprotein 2. (203 aa)
	PROS1	Protein S. (678 aa)
	M3XUY4_MUSPF	Uncharacterized protein. (417 aa)
	M3XUZ6_MUSPF	Uncharacterized protein. (294 aa)
	ADGRE5	Adhesion G protein-coupled receptor E5; Belongs to the G-protein coupled receptor 2 family. (833 aa)
	BDKRB1	Bradykinin receptor B1; Belongs to the G-protein coupled receptor 1 family. (387 aa)
	SERPINA5	Serpin family A member 5; Belongs to the serpin family. (445 aa)
	AHSG	Alpha 2-HS glycoprotein. (352 aa)
	FETUB	Fetuin B. (354 aa)
	SERPINA9	Serpin family A member 9; Belongs to the serpin family. (463 aa)
	HRG	Histidine rich glycoprotein. (534 aa)
	M3XVV7_MUSPF	SERPIN domain-containing protein; Belongs to the serpin family. (427 aa)
	M3XVV9_MUSPF	SERPIN domain-containing protein; Belongs to the serpin family. (371 aa)
	KNG1	Kininogen 1. (661 aa)
	F3	Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (292 aa)
	PLAU	Plasminogen activator, urokinase. (432 aa)
	MASP1	Mannan binding lectin serine peptidase 1. (699 aa)
	M3XWV0_MUSPF	C-type lectin domain-containing protein. (244 aa)
	SERPIND1	Serpin family D member 1; Belongs to the serpin family. (496 aa)
	GP5	Glycoprotein V platelet. (482 aa)
	APOA5	Apolipoprotein A5. (370 aa)
	PLG	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (810 aa)
	SERPINC1	Serpin family C member 1; Belongs to the serpin family. (531 aa)
	CDC37L1	Cell division cycle 37 like 1. (337 aa)
	F2	Coagulation factor II, thrombin; Belongs to the peptidase S1 family. (602 aa)
	SERPINA7	Serpin family A member 7; Belongs to the serpin family. (422 aa)
	FGB	Fibrinogen beta chain. (495 aa)
	FGA	Fibrinogen alpha chain. (825 aa)
	FGG	Fibrinogen gamma chain. (437 aa)
	HPX	Hemopexin. (463 aa)
	PLAT	Plasminogen activator, tissue type. (639 aa)
	PLAUR	Plasminogen activator, urokinase receptor. (319 aa)
	SSPO	SCO-spondin. (5101 aa)
	M3Y683_MUSPF	Uncharacterized protein. (1658 aa)
	C3	Complement C3. (1668 aa)
	C8A	Complement C8 alpha chain. (589 aa)
	C8B	Complement C8 beta chain. (590 aa)
	C5	Complement C5. (1678 aa)
	AMBP	Alpha-1-microglobulin/bikunin precursor. (352 aa)
	FCER2	Fc fragment of IgE receptor II. (325 aa)
	M3YB47_MUSPF	Uncharacterized protein; Belongs to the peptidase S1 family. (533 aa)
	AFM	Afamin. (604 aa)
	GC	GC vitamin D binding protein. (474 aa)
	M3YEG3_MUSPF	Uncharacterized protein. (619 aa)
	M3YEH1_MUSPF	Uncharacterized protein. (316 aa)
	M3YEH5_MUSPF	Uncharacterized protein. (1473 aa)
	M3YEI9_MUSPF	Uncharacterized protein. (558 aa)
	LOC101691328	Uncharacterized protein. (212 aa)
	C4BPA	Uncharacterized protein. (605 aa)
	C4BPB	Complement component 4 binding protein beta. (256 aa)
	LECT2	Leukocyte cell derived chemotaxin 2. (151 aa)
	F13B	Coagulation factor XIII B chain. (661 aa)
	F10	Coagulation factor X. (634 aa)
	KLKB1	Kallikrein B1; Belongs to the peptidase S1 family. (634 aa)
	F11	Coagulation factor XI; Belongs to the peptidase S1 family. (636 aa)
	F7	Coagulation factor VII. (450 aa)
	C4A	Uncharacterized protein. (1822 aa)
	M3YGU6_MUSPF	Uncharacterized protein; Belongs to the peptidase S1 family. (1184 aa)
	C8G	Complement C8 gamma chain; Belongs to the calycin superfamily. Lipocalin family. (212 aa)
	SLCO1B3	Solute carrier organic anion transporter family member. (693 aa)
	M3YJC7_MUSPF	UPAR/Ly6 domain-containing protein. (117 aa)
	PLBD1	Phospholipase B-like; Putative phospholipase. (506 aa)
	PROC	Protein C, inactivator of coagulation factors Va and VIIIa. (485 aa)
	F12	Coagulation factor XII. (610 aa)
	M3YKW1_MUSPF	Fibrinogen C-terminal domain-containing protein. (393 aa)
	M3YL16_MUSPF	Fibrinogen C-terminal domain-containing protein. (387 aa)
	M3YMW0_MUSPF	Uncharacterized protein. (928 aa)
	APCS	Pentaxin. (224 aa)
	CRP	Pentaxin. (221 aa)
	SERPINF2	Serpin family F member 2; Belongs to the serpin family. (491 aa)
	CFP	Complement factor properdin. (465 aa)
	GZMK	Granzyme K; Belongs to the peptidase S1 family. (268 aa)
	C6	Complement C6. (955 aa)
	APOH	Apolipoprotein H. (345 aa)
	C7	Complement C7. (844 aa)
	C9	Complement C9. (552 aa)
	F5	Coagulation factor V; Belongs to the multicopper oxidase family. (2021 aa)
	SERPINE1	Serpin peptidase inhibitor, clade E, member 1; Belongs to the serpin family. (400 aa)
	F8	Coagulation factor VIII; Belongs to the multicopper oxidase family. (2333 aa)
	ITIH2	Inter-alpha-trypsin inhibitor heavy chain 2. (946 aa)
	MASP2	Mannan binding lectin serine peptidase 2; Belongs to the peptidase S1 family. (688 aa)
	SERPINB2	Serpin family B member 2; Belongs to the serpin family. (415 aa)
	SERPINE2	Serpin family E member 2; Belongs to the serpin family. (411 aa)
	C1RL	Complement C1r subcomponent like; Belongs to the peptidase S1 family. (481 aa)
	C1R	Complement C1r; Belongs to the peptidase S1 family. (705 aa)
	C1S	Complement C1s; Belongs to the peptidase S1 family. (695 aa)
	ITIH1	Inter-alpha-trypsin inhibitor heavy chain 1. (910 aa)
	ITIH3	Inter-alpha-trypsin inhibitor heavy chain 3. (991 aa)
	ITIH4	Inter-alpha-trypsin inhibitor heavy chain 4. (930 aa)
	VWF	Von Willebrand factor. (2814 aa)
	PROCR	Protein C receptor. (238 aa)
	THBD	Thrombomodulin. (567 aa)
	M3Z7P0_MUSPF	LRRCT domain-containing protein. (682 aa)
	GP1BB	Glycoprotein Ib platelet subunit beta. (209 aa)
	GP9	Glycoprotein IX platelet. (177 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCB11	HPX	ENSMPUP00000000733	ENSMPUP00000005670	ATP binding cassette subfamily B member 11.	Hemopexin.	0.811
ABCB11	SLCO1B3	ENSMPUP00000000733	ENSMPUP00000011209	ATP binding cassette subfamily B member 11.	Solute carrier organic anion transporter family member.	0.597
ADGRE5	M3YEI9_MUSPF	ENSMPUP00000003028	ENSMPUP00000009746	Adhesion G protein-coupled receptor E5; Belongs to the G-protein coupled receptor 2 family.	Uncharacterized protein.	0.995
ADGRE5	M3YJC7_MUSPF	ENSMPUP00000003028	ENSMPUP00000011434	Adhesion G protein-coupled receptor E5; Belongs to the G-protein coupled receptor 2 family.	UPAR/Ly6 domain-containing protein.	0.424
AFM	APCS	ENSMPUP00000009187	ENSMPUP00000013007	Afamin.	Pentaxin.	0.494
AFM	APOH	ENSMPUP00000009187	ENSMPUP00000014552	Afamin.	Apolipoprotein H.	0.604
AFM	CRP	ENSMPUP00000009187	ENSMPUP00000013013	Afamin.	Pentaxin.	0.494
AFM	FETUB	ENSMPUP00000009187	ENSMPUP00000003194	Afamin.	Fetuin B.	0.508
AFM	HRG	ENSMPUP00000009187	ENSMPUP00000003198	Afamin.	Histidine rich glycoprotein.	0.623
AFM	ITIH4	ENSMPUP00000009187	ENSMPUP00000016680	Afamin.	Inter-alpha-trypsin inhibitor heavy chain 4.	0.482
AFM	MASP2	ENSMPUP00000009187	ENSMPUP00000016336	Afamin.	Mannan binding lectin serine peptidase 2; Belongs to the peptidase S1 family.	0.499
AHSG	AMBP	ENSMPUP00000003190	ENSMPUP00000008037	Alpha 2-HS glycoprotein.	Alpha-1-microglobulin/bikunin precursor.	0.878
AHSG	APOA5	ENSMPUP00000003190	ENSMPUP00000004110	Alpha 2-HS glycoprotein.	Apolipoprotein A5.	0.593
AHSG	APOH	ENSMPUP00000003190	ENSMPUP00000014552	Alpha 2-HS glycoprotein.	Apolipoprotein H.	0.931
AHSG	C3	ENSMPUP00000003190	ENSMPUP00000006928	Alpha 2-HS glycoprotein.	Complement C3.	0.549
AHSG	C4A	ENSMPUP00000003190	ENSMPUP00000010461	Alpha 2-HS glycoprotein.	Uncharacterized protein.	0.415
AHSG	C9	ENSMPUP00000003190	ENSMPUP00000014684	Alpha 2-HS glycoprotein.	Complement C9.	0.618
AHSG	F12	ENSMPUP00000003190	ENSMPUP00000011936	Alpha 2-HS glycoprotein.	Coagulation factor XII.	0.551
AHSG	F2	ENSMPUP00000003190	ENSMPUP00000005272	Alpha 2-HS glycoprotein.	Coagulation factor II, thrombin; Belongs to the peptidase S1 family.	0.941
AHSG	F5	ENSMPUP00000003190	ENSMPUP00000015392	Alpha 2-HS glycoprotein.	Coagulation factor V; Belongs to the multicopper oxidase family.	0.481