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| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (994 aa) |
| | POLA1 | DNA polymerase. (1467 aa) |
| | ORC2 | Origin recognition complex subunit 2. (578 aa) |
| | M3XMG0_MUSPF | PARP-type domain-containing protein. (289 aa) |
| | TIPIN | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (293 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (698 aa) |
| | CHD1L | Chromodomain helicase DNA binding protein 1 like. (898 aa) |
| | DCLRE1C | DNA cross-link repair 1C. (691 aa) |
| | MCM10 | Minichromosome maintenance 10 replication initiation factor. (874 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (920 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4110 aa) |
| | DSCC1 | DNA replication and sister chromatid cohesion 1. (493 aa) |
| | M3XQS3_MUSPF | Uncharacterized protein. (272 aa) |
| | M3XQT3_MUSPF | Uncharacterized protein. (1208 aa) |
| | M3XR87_MUSPF | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (419 aa) |
| | POLD1 | DNA polymerase. (1107 aa) |
| | NEIL2 | Nei like DNA glycosylase 2. (334 aa) |
| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | BRCA2 | BRCA2 DNA repair associated. (3466 aa) |
| | RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (424 aa) |
| | RMI1 | RecQ mediated genome instability 1. (564 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (810 aa) |
| | PNKP | Polynucleotide kinase 3'-phosphatase. (520 aa) |
| | XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (349 aa) |
| | M3XTN7_MUSPF | Uncharacterized protein. (328 aa) |
| | ZRANB3 | Zinc finger RANBP2-type containing 3. (1066 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2275 aa) |
| | PRIM2 | DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (509 aa) |
| | ORC6 | Origin recognition complex subunit 6. (252 aa) |
| | RFC5 | Replication factor C subunit 5. (340 aa) |
| | MLH1 | MutL homolog 1. (758 aa) |
| | WDR11 | WD repeat domain 11. (1200 aa) |
| | MCMBP | Minichromosome maintenance complex binding protein. (570 aa) |
| | TOP3B | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (862 aa) |
| | APEX2 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (515 aa) |
| | RFC4 | Replication factor C subunit 4. (360 aa) |
| | UNG | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (304 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa) |
| | G9KHN4_MUSPF | Polymerase, delta 4. (140 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (385 aa) |
| | CDC45 | Cell division cycle 45. (567 aa) |
| | M3XXT4_MUSPF | Uncharacterized protein. (124 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1145 aa) |
| | CYREN | Cell cycle regulator of NHEJ. (155 aa) |
| | LIG1 | DNA ligase. (915 aa) |
| | CDC7 | Cell division cycle 7. (575 aa) |
| | GMNN | Geminin DNA replication inhibitor. (210 aa) |
| | PIEZO2 | Piezo-type mechanosensitive ion channel component. (2764 aa) |
| | GINS3 | GINS complex subunit 3. (216 aa) |
| | FANCM | FA complementation group M. (2036 aa) |
| | POLE2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (539 aa) |
| | WDHD1 | WD repeat and HMG-box DNA binding protein 1. (1130 aa) |
| | POLK | DNA polymerase kappa. (870 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (897 aa) |
| | GINS4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa) |
| | SMUG1 | Single-strand-selective monofunctional uracil-DNA glycosylase 1. (269 aa) |
| | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (294 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3057 aa) |
| | RFC1 | Replication factor C subunit 1. (1155 aa) |
| | RECQL4 | RecQ like helicase 4. (1077 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | M3Y4M7_MUSPF | MCM domain-containing protein; Belongs to the MCM family. (833 aa) |
| | XPA | XPA, DNA damage recognition and repair factor. (275 aa) |
| | ERCC6L2 | ERCC excision repair 6 like 2. (921 aa) |
| | XRCC1 | X-ray repair cross complementing 1. (646 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (862 aa) |
| | RAD51B | RAD51 paralog B. (281 aa) |
| | M3Y7A6_MUSPF | Rad51 domain-containing protein. (120 aa) |
| | M3Y8U7_MUSPF | CDT1 domain-containing protein. (347 aa) |
| | BARD1 | BRCA1 associated RING domain 1. (767 aa) |
| | POLE3 | DNA polymerase epsilon 3, accessory subunit. (147 aa) |
| | XRCC4 | X-ray repair cross complementing 4. (506 aa) |
| | POLE4 | DNA polymerase epsilon 4, accessory subunit. (114 aa) |
| | RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1269 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (340 aa) |
| | HMGN1 | High mobility group nucleosome binding domain 1. (133 aa) |
| | MSH3 | MutS homolog 3. (869 aa) |
| | M3YBC5_MUSPF | Uncharacterized protein. (130 aa) |
| | M3YBV1_MUSPF | Uncharacterized protein. (809 aa) |
| | M3YC47_MUSPF | Uncharacterized protein. (335 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (808 aa) |
| | MLH3 | MutL homolog 3. (1460 aa) |
| | ERCC6 | ERCC excision repair 6, chromatin remodeling factor. (1482 aa) |
| | POLD3 | DNA polymerase delta 3, accessory subunit. (465 aa) |
| | XRCC2 | X-ray repair cross complementing 2. (280 aa) |
| | RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (255 aa) |
| | ORC3 | Origin recognition complex subunit 3. (711 aa) |
| | TDRD3 | Tudor domain containing 3. (693 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1466 aa) |
| | M3YEG5_MUSPF | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (766 aa) |
| | MCMDC2 | Minichromosome maintenance domain containing 2. (680 aa) |
| | REV3L | REV3 like, DNA directed polymerase zeta catalytic subunit. (3130 aa) |
| | WRN | WRN RecQ like helicase. (1397 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (1969 aa) |
| | M3YG30_MUSPF | XRCC1_N domain-containing protein. (403 aa) |
| | M3YGI1_MUSPF | Zinc-hook domain-containing protein. (1312 aa) |
| | MSH4 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (936 aa) |
| | PAXX | PAXX non-homologous end joining factor. (204 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (672 aa) |
| | M3YHV3_MUSPF | DNA_MISMATCH_REPAIR_2 domain-containing protein. (833 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (749 aa) |
| | MSH6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1360 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa) |
| | UVSSA | UV stimulated scaffold protein A. (706 aa) |
| | ERCC5 | ERCC excision repair 5, endonuclease. (1193 aa) |
| | MUS81 | MUS81 structure-specific endonuclease subunit. (546 aa) |
| | M3YJH8_MUSPF | Uncharacterized protein. (196 aa) |
| | CETN2 | Centrin 2. (178 aa) |
| | M3YKP9_MUSPF | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (595 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa) |
| | REV1 | DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1254 aa) |
| | NEIL3 | Nei like DNA glycosylase 3. (517 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1063 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (707 aa) |
| | PMS1 | PMS1 homolog 1, mismatch repair system component. (930 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (736 aa) |
| | POLB | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa) |
| | RAD54L | RAD54 like. (748 aa) |
| | POLH | DNA polymerase eta. (649 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa) |
| | M3YNX6_MUSPF | Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (547 aa) |
| | DMC1 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (288 aa) |
| | CHEK2 | Checkpoint kinase 2. (544 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (907 aa) |
| | RECQL5 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (986 aa) |
| | MCM9 | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1145 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (916 aa) |
| | RAD17 | RAD17 checkpoint clamp loader component. (680 aa) |
| | ATAD5 | ATPase family AAA domain containing 5. (1892 aa) |
| | USP7 | Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1055 aa) |
| | M3YTL6_MUSPF | DNA_pol_D_N domain-containing protein. (323 aa) |
| | LIG3 | DNA ligase. (937 aa) |
| | RAD51D | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (396 aa) |
| | CLSPN | Claspin. (1336 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (558 aa) |
| | ATRIP | ATR interacting protein. (700 aa) |
| | SLX4 | SLX4 structure-specific endonuclease subunit. (1765 aa) |
| | RAD1 | RAD1 checkpoint DNA exonuclease. (281 aa) |
| | BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (1198 aa) |
| | RAD51C | RAD51 paralog C. (371 aa) |
| | EME1 | Essential meiotic structure-specific endonuclease 1. (573 aa) |
| | NTHL1 | Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (317 aa) |
| | RPA2 | Replication protein A2. (270 aa) |
| | MEIOB | Meiosis specific with OB-fold. (471 aa) |
| | EME2 | Essential meiotic structure-specific endonuclease subunit 2. (387 aa) |
| | BLM | BLM RecQ like helicase. (1221 aa) |
| | EXO1 | Exonuclease 1. (836 aa) |
| | GINS1 | GINS complex subunit 1. (196 aa) |
| | CHTF18 | Chromosome transmission fidelity factor 18. (979 aa) |
| | RFC2 | Replication factor C subunit 2. (352 aa) |
| | FBH1 | F-box DNA helicase 1. (1045 aa) |
| | XRCC6 | X-ray repair cross complementing 6. (580 aa) |
| | MAD2L2 | Mitotic arrest deficient 2 like 2. (211 aa) |
| | XRCC5 | X-ray repair cross complementing 5. (733 aa) |
| | NHEJ1 | Non-homologous end joining factor 1. (299 aa) |
| | CNPPD1 | Cyclin Pas1/PHO80 domain containing 1. (411 aa) |
| | PMS2 | PMS1 homolog 2, mismatch repair system component. (861 aa) |
| | POLL | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (595 aa) |
| | OGG1 | 8-oxoguanine DNA glycosylase. (345 aa) |
| | MBD4 | Methyl-CpG-binding domain protein 4; Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. (565 aa) |
| | M3Z0N7_MUSPF | Uncharacterized protein. (978 aa) |
| | NEIL1 | Nei like DNA glycosylase 1. (344 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (903 aa) |
| | HELB | DNA helicase B. (1080 aa) |
| | RAD52 | RAD52 homolog, DNA repair protein. (416 aa) |
| | M3Z348_MUSPF | Uncharacterized protein. (107 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (280 aa) |
| | M3Z3C9_MUSPF | Uncharacterized protein. (321 aa) |
| | M3Z3D2_MUSPF | DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (420 aa) |
| | ORC5 | Origin recognition complex subunit 5. (435 aa) |
| | DBF4 | DBF4 zinc finger. (683 aa) |
| | LIG4 | DNA ligase. (911 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
