(28 nodes) Transcription coactivator binding network (Mustela putorius)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SMAD3	Mothers against decapentaplegic homolog. (414 aa)
	VGLL4	Vestigial like family member 4. (296 aa)
	EP300	E1A binding protein p300. (2425 aa)
	GATA3	GATA binding protein 3. (444 aa)
	ZBTB17	Zinc finger and BTB domain containing 17. (667 aa)
	ZBTB8A	Zinc finger and BTB domain containing 8A. (441 aa)
	CREBBP	CREB binding protein. (2442 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (597 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	M3Y996_MUSPF	Uncharacterized protein. (445 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (824 aa)
	M3Y3I1_MUSPF	Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. (488 aa)
	GATA6	GATA binding protein 6. (482 aa)
	MED6	Mediator of RNA polymerase II transcription subunit 6; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (246 aa)
	PPARD	Peroxisome proliferator activated receptor delta. (366 aa)
	CIT	Citron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (2069 aa)
	TEAD2	TEA domain transcription factor 2. (545 aa)
	CCNT2	Cyclin T2; Belongs to the cyclin family. (759 aa)
	MED25	Mediator complex subunit 25. (836 aa)
	RORA	RAR related orphan receptor A. (430 aa)
	M3YU90_MUSPF	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (616 aa)
	AR	Androgen receptor. (892 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (511 aa)
	EPAS1	Endothelial PAS domain protein 1. (868 aa)
	THRB	Thyroid hormone receptor beta. (461 aa)
	GATA1	GATA binding protein 1. (414 aa)
	CDK9	Cyclin dependent kinase 9; Belongs to the protein kinase superfamily. (372 aa)
	M3YRA0_MUSPF	Uncharacterized protein. (848 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	CREBBP	ENSMPUP00000010444	ENSMPUP00000014925	Androgen receptor.	CREB binding protein.	0.699
AR	EP300	ENSMPUP00000010444	ENSMPUP00000016323	Androgen receptor.	E1A binding protein p300.	0.707
AR	ESR1	ENSMPUP00000010444	ENSMPUP00000010404	Androgen receptor.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.597
AR	HIF1A	ENSMPUP00000010444	ENSMPUP00000006460	Androgen receptor.	Hypoxia inducible factor 1 subunit alpha.	0.503
AR	M3YU90_MUSPF	ENSMPUP00000010444	ENSMPUP00000014900	Androgen receptor.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.615
AR	RELA	ENSMPUP00000010444	ENSMPUP00000011545	Androgen receptor.	RELA proto-oncogene, NF-kB subunit.	0.464
AR	SMAD3	ENSMPUP00000010444	ENSMPUP00000000302	Androgen receptor.	Mothers against decapentaplegic homolog.	0.584
AR	SMAD4	ENSMPUP00000010444	ENSMPUP00000008705	Androgen receptor.	Mothers against decapentaplegic homolog.	0.488
CCNT2	CDK9	ENSMPUP00000002519	ENSMPUP00000013578	Cyclin T2; Belongs to the cyclin family.	Cyclin dependent kinase 9; Belongs to the protein kinase superfamily.	0.999
CCNT2	SMAD4	ENSMPUP00000002519	ENSMPUP00000008705	Cyclin T2; Belongs to the cyclin family.	Mothers against decapentaplegic homolog.	0.413
CDK9	CCNT2	ENSMPUP00000013578	ENSMPUP00000002519	Cyclin dependent kinase 9; Belongs to the protein kinase superfamily.	Cyclin T2; Belongs to the cyclin family.	0.999
CDK9	ESR1	ENSMPUP00000013578	ENSMPUP00000010404	Cyclin dependent kinase 9; Belongs to the protein kinase superfamily.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.621
CDK9	M3YU90_MUSPF	ENSMPUP00000013578	ENSMPUP00000014900	Cyclin dependent kinase 9; Belongs to the protein kinase superfamily.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.920
CDK9	RELA	ENSMPUP00000013578	ENSMPUP00000011545	Cyclin dependent kinase 9; Belongs to the protein kinase superfamily.	RELA proto-oncogene, NF-kB subunit.	0.469
CDK9	SMAD4	ENSMPUP00000013578	ENSMPUP00000008705	Cyclin dependent kinase 9; Belongs to the protein kinase superfamily.	Mothers against decapentaplegic homolog.	0.588
CREBBP	AR	ENSMPUP00000014925	ENSMPUP00000010444	CREB binding protein.	Androgen receptor.	0.699
CREBBP	EP300	ENSMPUP00000014925	ENSMPUP00000016323	CREB binding protein.	E1A binding protein p300.	0.996
CREBBP	EPAS1	ENSMPUP00000014925	ENSMPUP00000011927	CREB binding protein.	Endothelial PAS domain protein 1.	0.980
CREBBP	ESR1	ENSMPUP00000014925	ENSMPUP00000010404	CREB binding protein.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.886
CREBBP	GATA1	ENSMPUP00000014925	ENSMPUP00000013553	CREB binding protein.	GATA binding protein 1.	0.567