STRINGSTRING
SPRY1 SPRY1 TGFB1 TGFB1 FGF2 FGF2 RET RET LZTS2 LZTS2 SLIT2 SLIT2 WNT6 WNT6 GATA3 GATA3 KIF26B KIF26B CRLF1 CRLF1 TMEM59L TMEM59L LHX1 LHX1 GDNF GDNF TCF21 TCF21 WNT1 WNT1 SOX9 SOX9 OSR1 OSR1 GREB1 GREB1 FOXJ1 FOXJ1 GPC3 GPC3 RARB RARB WT1 WT1 CALB1 CALB1 EYA1 EYA1 SMAD5 SMAD5 PAX8 PAX8 NPNT NPNT WNT11 WNT11 SMAD4 SMAD4 WNT9B WNT9B DLG2 DLG2 FGF1 FGF1 ADAMTS16 ADAMTS16 ARG2 ARG2 SMAD1 SMAD1 PTCH1 PTCH1 BMP7 BMP7 BMP2 BMP2 M3Y377_MUSPF M3Y377_MUSPF BMPER BMPER GREB1L GREB1L ILK ILK BMP4 BMP4 M3Y0D8_MUSPF M3Y0D8_MUSPF HOXA11 HOXA11 DLG1 DLG1 HES1 HES1 PKD2 PKD2 SMAD3 SMAD3 SMAD6 SMAD6 SMAD7 SMAD7 GDF11 GDF11 GZF1 GZF1 TACSTD2 TACSTD2 GREM1 GREM1 GLI3 GLI3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SPRY1Sprouty-like protein 1, antagonist of FGF signaling. (319 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1028 aa)
LZTS2Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (670 aa)
SLIT2Slit guidance ligand 2. (1539 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
GATA3GATA binding protein 3. (444 aa)
KIF26BKinesin family member 26B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1878 aa)
CRLF1Cytokine receptor like factor 1. (383 aa)
TMEM59LTransmembrane protein 59 like. (351 aa)
LHX1LIM homeobox 1. (406 aa)
GDNFGlial cell derived neurotrophic factor. (211 aa)
TCF21Transcription factor 21. (179 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (340 aa)
SOX9SRY-box transcription factor 9. (522 aa)
OSR1Odd-skipped related transcription factor 1. (267 aa)
GREB1Uncharacterized protein. (1955 aa)
FOXJ1Forkhead box J1. (421 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (580 aa)
RARBRetinoic acid receptor beta. (448 aa)
WT1WT1 transcription factor. (433 aa)
CALB1Calbindin 1. (261 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (621 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
PAX8Paired box 8. (462 aa)
NPNTNephronectin. (597 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
DLG2Uncharacterized protein. (833 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
ADAMTS16ADAM metallopeptidase with thrombospondin type 1 motif 16. (1169 aa)
ARG2Arginase. (354 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
PTCH1Patched 1. (1386 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
M3Y377_MUSPFNTR domain-containing protein. (233 aa)
BMPERBMP binding endothelial regulator. (685 aa)
GREB1LGREB1 like retinoic acid receptor coactivator. (1971 aa)
ILKIntegrin linked kinase. (452 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
M3Y0D8_MUSPFUncharacterized protein. (356 aa)
HOXA11Homeobox A11. (269 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (927 aa)
HES1Hes family bHLH transcription factor 1. (283 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (915 aa)
SMAD3Mothers against decapentaplegic homolog. (414 aa)
SMAD6Mothers against decapentaplegic homolog. (494 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
GDF11Growth differentiation factor 11. (404 aa)
GZF1GDNF inducible zinc finger protein 1. (806 aa)
TACSTD2Tumor associated calcium signal transducer 2. (316 aa)
GREM1Gremlin. (184 aa)
GLI3GLI family zinc finger 3. (1585 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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