(56 nodes) Epithelial to mesenchymal transition network (Mustela putorius)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EFNA1	Ephrin A1; Belongs to the ephrin family. (175 aa)
	TRIM28	Tripartite motif containing 28. (700 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (420 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	LEF1	Lymphoid enhancer binding factor 1. (400 aa)
	M3YCX9_MUSPF	Uncharacterized protein; Belongs to the DEAD box helicase family. (671 aa)
	FLNA	Filamin A. (2647 aa)
	WNT8A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
	NOTCH4	Notch receptor 4. (1993 aa)
	PDCD6	Programmed cell death 6. (189 aa)
	RTN4	Reticulon. (986 aa)
	SNAI2	Snail family transcriptional repressor 2. (268 aa)
	KLHL12	Kelch like family member 12. (548 aa)
	NOTCH1	Notch receptor 1. (2119 aa)
	LOXL2	Lysyl oxidase like 2. (772 aa)
	LRP6	LDL receptor related protein 6. (1462 aa)
	CUL7	Cullin 7; Belongs to the cullin family. (1687 aa)
	DDX17	DEAD-box helicase 17; Belongs to the DEAD box helicase family. (650 aa)
	ENG	Endoglin. (653 aa)
	RFLNB	Refilin B. (158 aa)
	M3YQS9_MUSPF	LisH domain-containing protein. (1295 aa)
	SOX9	SRY-box transcription factor 9. (522 aa)
	M3YT25_MUSPF	Uncharacterized protein; Belongs to the DEAD box helicase family. (372 aa)
	TMEM100	Transmembrane protein 100. (134 aa)
	PEF1	Penta-EF-hand domain containing 1. (289 aa)
	TASOR2	Transcription activation suppressor family member 2. (2685 aa)
	TASOR	Transcription activation suppressor. (1516 aa)
	NOLC1	Nucleolar and coiled-body phosphoprotein 1. (715 aa)
	KBTBD8	Kelch repeat and BTB domain containing 8. (601 aa)
	M3Z1E7_MUSPF	Uncharacterized protein. (109 aa)
	SNAI1	Snail family transcriptional repressor 1. (264 aa)
	TGFB1	Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
	FAM83D	Family with sequence similarity 83 member D. (621 aa)
	GSC	Goosecoid homeobox. (256 aa)
	LOXL3	Lysyl oxidase like 3. (753 aa)
	MSX1	Msh homeobox 1. (303 aa)
	WNT2	Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	M3XVG1_MUSPF	Helicase C-terminal domain-containing protein. (106 aa)
	TBX3	T-box transcription factor 3. (757 aa)
	AKNA	AT-hook transcription factor. (1425 aa)
	HAS2	Hyaluronan synthase 2. (552 aa)
	EDN1	Endothelin 1. (202 aa)
	M3XMZ0_MUSPF	LisH domain-containing protein. (1132 aa)
	ROCK1	Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1252 aa)
	TGFBR3	Transforming growth factor beta receptor 3. (858 aa)
	TGFB2	Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (414 aa)
	DLG5	Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1922 aa)
	WNT16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (480 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (824 aa)
	BMP2	Bone morphogenetic protein 2. (395 aa)
	M3Y4E6_MUSPF	Uncharacterized protein. (160 aa)
	M3Y377_MUSPF	NTR domain-containing protein. (233 aa)
	ADAM15	ADAM metallopeptidase domain 15. (860 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAM15	EFNA1	ENSMPUP00000005730	ENSMPUP00000005666	ADAM metallopeptidase domain 15.	Ephrin A1; Belongs to the ephrin family.	0.810
BMP2	SMAD4	ENSMPUP00000006323	ENSMPUP00000008705	Bone morphogenetic protein 2.	Mothers against decapentaplegic homolog.	0.836
BMP2	SOX9	ENSMPUP00000006323	ENSMPUP00000014195	Bone morphogenetic protein 2.	SRY-box transcription factor 9.	0.573
BMP2	TGFB1	ENSMPUP00000006323	ENSMPUP00000017540	Bone morphogenetic protein 2.	Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...]	0.463
BMP2	TGFBR1	ENSMPUP00000006323	ENSMPUP00000006622	Bone morphogenetic protein 2.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.699
CUL7	KLHL12	ENSMPUP00000013019	ENSMPUP00000011116	Cullin 7; Belongs to the cullin family.	Kelch like family member 12.	0.462
DDX17	M3XVG1_MUSPF	ENSMPUP00000013028	ENSMPUP00000003061	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	Helicase C-terminal domain-containing protein.	0.679
DDX17	M3YCX9_MUSPF	ENSMPUP00000013028	ENSMPUP00000009186	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	Uncharacterized protein; Belongs to the DEAD box helicase family.	0.681
DDX17	M3YT25_MUSPF	ENSMPUP00000013028	ENSMPUP00000014485	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	Uncharacterized protein; Belongs to the DEAD box helicase family.	0.679
EDN1	EDNRA	ENSMPUP00000000674	ENSMPUP00000006929	Endothelin 1.	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	0.999
EDN1	ENG	ENSMPUP00000000674	ENSMPUP00000013475	Endothelin 1.	Endoglin.	0.526
EDN1	HIF1A	ENSMPUP00000000674	ENSMPUP00000006460	Endothelin 1.	Hypoxia inducible factor 1 subunit alpha.	0.495
EDN1	TGFB1	ENSMPUP00000000674	ENSMPUP00000017540	Endothelin 1.	Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...]	0.565
EDNRA	EDN1	ENSMPUP00000006929	ENSMPUP00000000674	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	Endothelin 1.	0.999
EFNA1	ADAM15	ENSMPUP00000005666	ENSMPUP00000005730	Ephrin A1; Belongs to the ephrin family.	ADAM metallopeptidase domain 15.	0.810
ENG	EDN1	ENSMPUP00000013475	ENSMPUP00000000674	Endoglin.	Endothelin 1.	0.526
ENG	TGFB1	ENSMPUP00000013475	ENSMPUP00000017540	Endoglin.	Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...]	0.804
ENG	TGFB2	ENSMPUP00000013475	ENSMPUP00000004208	Endoglin.	Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...]	0.502
ENG	TGFBR1	ENSMPUP00000013475	ENSMPUP00000006622	Endoglin.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.693
FLNA	HIF1A	ENSMPUP00000009219	ENSMPUP00000006460	Filamin A.	Hypoxia inducible factor 1 subunit alpha.	0.620