node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACVRL1 | GDF2 | ENSMPUP00000007801 | ENSMPUP00000008940 | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | Growth differentiation factor 2. | 0.993 |
ACVRL1 | TGFBR1 | ENSMPUP00000007801 | ENSMPUP00000006622 | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. | 0.515 |
CAV1 | CAV2 | ENSMPUP00000007166 | ENSMPUP00000007174 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] | Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (B [...] | 0.999 |
CAV1 | STAT1 | ENSMPUP00000007166 | ENSMPUP00000012436 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] | Signal transducer and activator of transcription. | 0.434 |
CAV1 | TGFBR1 | ENSMPUP00000007166 | ENSMPUP00000006622 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. | 0.512 |
CAV1 | TNF | ENSMPUP00000007166 | ENSMPUP00000011297 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] | Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family. | 0.420 |
CAV2 | CAV1 | ENSMPUP00000007174 | ENSMPUP00000007166 | Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (B [...] | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] | 0.999 |
DLL4 | FLT1 | ENSMPUP00000008700 | ENSMPUP00000004662 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | Receptor protein-tyrosine kinase. | 0.412 |
FLT1 | DLL4 | ENSMPUP00000004662 | ENSMPUP00000008700 | Receptor protein-tyrosine kinase. | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | 0.412 |
GDF2 | ACVRL1 | ENSMPUP00000008940 | ENSMPUP00000007801 | Growth differentiation factor 2. | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | 0.993 |
GDF2 | TGFBR1 | ENSMPUP00000008940 | ENSMPUP00000006622 | Growth differentiation factor 2. | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. | 0.622 |
M3YAR0_MUSPF | PDCD10 | ENSMPUP00000008417 | ENSMPUP00000016967 | Uncharacterized protein. | Programmed cell death 10. | 0.888 |
PDCD10 | M3YAR0_MUSPF | ENSMPUP00000016967 | ENSMPUP00000008417 | Programmed cell death 10. | Uncharacterized protein. | 0.888 |
STAT1 | CAV1 | ENSMPUP00000012436 | ENSMPUP00000007166 | Signal transducer and activator of transcription. | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] | 0.434 |
STAT1 | TNF | ENSMPUP00000012436 | ENSMPUP00000011297 | Signal transducer and activator of transcription. | Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family. | 0.664 |
TGFBR1 | ACVRL1 | ENSMPUP00000006622 | ENSMPUP00000007801 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | 0.515 |
TGFBR1 | CAV1 | ENSMPUP00000006622 | ENSMPUP00000007166 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] | 0.512 |
TGFBR1 | GDF2 | ENSMPUP00000006622 | ENSMPUP00000008940 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. | Growth differentiation factor 2. | 0.622 |
THBS1 | TNF | ENSMPUP00000008220 | ENSMPUP00000011297 | Thrombospondin 1. | Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family. | 0.471 |
TNF | CAV1 | ENSMPUP00000011297 | ENSMPUP00000007166 | Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family. | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] | 0.420 |