(11 nodes) Lymphangiogenesis network (Mustela putorius)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1045 aa)
	FLT4	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1355 aa)
	PPP3CB	Serine/threonine-protein phosphatase. (479 aa)
	HSD17B3	Hydroxysteroid 17-beta dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (306 aa)
	ACVRL1	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
	PROX1	Prospero homeobox 1. (737 aa)
	PTPN14	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (1088 aa)
	TIE1	Tyrosine kinase with immunoglobulin like and EGF like domains 1. (994 aa)
	PDPN	Podoplanin. (177 aa)
	CCBE1	Collagen and calcium binding EGF domains 1. (380 aa)
	CLEC14A	C-type lectin domain containing 14A. (489 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACVRL1	BMPR2	ENSMPUP00000007801	ENSMPUP00000000351	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.977
ACVRL1	CLEC14A	ENSMPUP00000007801	ENSMPUP00000019431	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	C-type lectin domain containing 14A.	0.402
BMPR2	ACVRL1	ENSMPUP00000000351	ENSMPUP00000007801	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.977
CCBE1	FLT4	ENSMPUP00000016381	ENSMPUP00000000573	Collagen and calcium binding EGF domains 1.	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.470
CCBE1	PTPN14	ENSMPUP00000016381	ENSMPUP00000013402	Collagen and calcium binding EGF domains 1.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily.	0.449
CLEC14A	ACVRL1	ENSMPUP00000019431	ENSMPUP00000007801	C-type lectin domain containing 14A.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.402
FLT4	CCBE1	ENSMPUP00000000573	ENSMPUP00000016381	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Collagen and calcium binding EGF domains 1.	0.470
FLT4	PDPN	ENSMPUP00000000573	ENSMPUP00000016251	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Podoplanin.	0.436
FLT4	PTPN14	ENSMPUP00000000573	ENSMPUP00000013402	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily.	0.497
PDPN	FLT4	ENSMPUP00000016251	ENSMPUP00000000573	Podoplanin.	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.436
PDPN	PROX1	ENSMPUP00000016251	ENSMPUP00000013354	Podoplanin.	Prospero homeobox 1.	0.499
PROX1	PDPN	ENSMPUP00000013354	ENSMPUP00000016251	Prospero homeobox 1.	Podoplanin.	0.499
PTPN14	CCBE1	ENSMPUP00000013402	ENSMPUP00000016381	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily.	Collagen and calcium binding EGF domains 1.	0.449
PTPN14	FLT4	ENSMPUP00000013402	ENSMPUP00000000573	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily.	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.497