(41 nodes) Heart looping network (Mustela putorius)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (790 aa)
	FOXH1	Forkhead box H1. (398 aa)
	SOX17	SRY-box transcription factor 17. (406 aa)
	NOTCH1	Notch receptor 1. (2119 aa)
	CCDC40	Coiled-coil domain containing 40. (1142 aa)
	TBX6	T-box transcription factor 6. (436 aa)
	MICAL2	Microtubule associated monooxygenase, calponin and LIM domain containing 2. (1124 aa)
	M3YNS9_MUSPF	BMERB domain-containing protein. (703 aa)
	SRF	Serum response factor. (508 aa)
	HAND1	Heart and neural crest derivatives expressed 1. (215 aa)
	M3YFG7_MUSPF	Uncharacterized protein. (135 aa)
	ENG	Endoglin. (653 aa)
	AHI1	Abelson helper integration site 1. (1171 aa)
	CLUAP1	Clusterin associated protein 1. (437 aa)
	TBX2	T-box transcription factor 2. (679 aa)
	IHH	Indian hedgehog signaling molecule. (384 aa)
	SMAD3	Mothers against decapentaplegic homolog. (414 aa)
	NOTCH2	Notch receptor 2. (2471 aa)
	ZIC3	Zic family member 3. (473 aa)
	HAND2	Heart and neural crest derivatives expressed 2. (208 aa)
	PKD2	Polycystin 2, transient receptor potential cation channel. (915 aa)
	TBX3	T-box transcription factor 3. (757 aa)
	ARL13B	ADP ribosylation factor like GTPase 13B. (430 aa)
	ASB2	Ankyrin repeat and SOCS box containing 2. (630 aa)
	SUFU	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (484 aa)
	CITED2	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (273 aa)
	APLNR	Apelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
	IFT52	Intraflagellar transport 52. (446 aa)
	LBX1	Ladybird homeobox 1. (281 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (824 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (602 aa)
	TBX20	T-box transcription factor 20. (446 aa)
	MEF2C	Myocyte enhancer factor 2C. (433 aa)
	DNAAF1	Dynein assembly factor 1, axonemal. (657 aa)
	CCDC103	Coiled-coil domain containing 103. (240 aa)
	C2CD3	C2 domain containing 3 centriole elongation regulator. (2334 aa)
	M3YE59_MUSPF	HH_signal domain-containing protein. (290 aa)
	NPHP3	TPR_REGION domain-containing protein. (1331 aa)
	IFT57	Intraflagellar transport 57. (429 aa)
	NODAL	Nodal growth differentiation factor. (348 aa)
	MIB1	Mindbomb E3 ubiquitin protein ligase 1. (1006 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHI1	ARL13B	ENSMPUP00000014707	ENSMPUP00000002697	Abelson helper integration site 1.	ADP ribosylation factor like GTPase 13B.	0.529
AHI1	NPHP3	ENSMPUP00000014707	ENSMPUP00000009744	Abelson helper integration site 1.	TPR_REGION domain-containing protein.	0.420
ARL13B	AHI1	ENSMPUP00000002697	ENSMPUP00000014707	ADP ribosylation factor like GTPase 13B.	Abelson helper integration site 1.	0.529
ARL13B	C2CD3	ENSMPUP00000002697	ENSMPUP00000009347	ADP ribosylation factor like GTPase 13B.	C2 domain containing 3 centriole elongation regulator.	0.739
ARL13B	IFT52	ENSMPUP00000002697	ENSMPUP00000017576	ADP ribosylation factor like GTPase 13B.	Intraflagellar transport 52.	0.696
ARL13B	IFT57	ENSMPUP00000002697	ENSMPUP00000009896	ADP ribosylation factor like GTPase 13B.	Intraflagellar transport 57.	0.736
ARL13B	IHH	ENSMPUP00000002697	ENSMPUP00000016454	ADP ribosylation factor like GTPase 13B.	Indian hedgehog signaling molecule.	0.578
ARL13B	M3YE59_MUSPF	ENSMPUP00000002697	ENSMPUP00000009616	ADP ribosylation factor like GTPase 13B.	HH_signal domain-containing protein.	0.578
ARL13B	NPHP3	ENSMPUP00000002697	ENSMPUP00000009744	ADP ribosylation factor like GTPase 13B.	TPR_REGION domain-containing protein.	0.759
ARL13B	PKD2	ENSMPUP00000002697	ENSMPUP00000002208	ADP ribosylation factor like GTPase 13B.	Polycystin 2, transient receptor potential cation channel.	0.756
ARL13B	SMO	ENSMPUP00000002697	ENSMPUP00000005835	ADP ribosylation factor like GTPase 13B.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.824
ARL13B	SUFU	ENSMPUP00000002697	ENSMPUP00000016762	ADP ribosylation factor like GTPase 13B.	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...]	0.452
C2CD3	ARL13B	ENSMPUP00000009347	ENSMPUP00000002697	C2 domain containing 3 centriole elongation regulator.	ADP ribosylation factor like GTPase 13B.	0.739
CCDC103	CCDC40	ENSMPUP00000009035	ENSMPUP00000012134	Coiled-coil domain containing 103.	Coiled-coil domain containing 40.	0.787
CCDC103	DNAAF1	ENSMPUP00000009035	ENSMPUP00000008854	Coiled-coil domain containing 103.	Dynein assembly factor 1, axonemal.	0.807
CCDC40	CCDC103	ENSMPUP00000012134	ENSMPUP00000009035	Coiled-coil domain containing 40.	Coiled-coil domain containing 103.	0.787
CCDC40	DNAAF1	ENSMPUP00000012134	ENSMPUP00000008854	Coiled-coil domain containing 40.	Dynein assembly factor 1, axonemal.	0.612
CCDC40	NPHP3	ENSMPUP00000012134	ENSMPUP00000009744	Coiled-coil domain containing 40.	TPR_REGION domain-containing protein.	0.459
CITED2	HIF1A	ENSMPUP00000018764	ENSMPUP00000006460	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2.	Hypoxia inducible factor 1 subunit alpha.	0.497
CLUAP1	IFT52	ENSMPUP00000014991	ENSMPUP00000017576	Clusterin associated protein 1.	Intraflagellar transport 52.	0.994