(49 nodes) Negative regulation of cytokine-mediated signaling pathway network (Mustela putorius)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	TTLL12	Tubulin tyrosine ligase like 12. (580 aa)
	SLIT2	Slit guidance ligand 2. (1539 aa)
	SAMHD1	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (626 aa)
	CNOT7	CCR4-NOT transcription complex subunit 7. (285 aa)
	M3Z434_MUSPF	Uncharacterized protein; Belongs to the MT-A70-like family. (570 aa)
	TREX1	Three prime repair exonuclease 1. (313 aa)
	YTHDF2	YTH N6-methyladenosine RNA binding protein 2. (580 aa)
	OTUD4	OTU deubiquitinase 4. (1111 aa)
	ADAR	Adenosine deaminase RNA specific. (1166 aa)
	CAV1	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
	OTOP1	Otopetrin 1. (616 aa)
	RFFL	Ring finger and FYVE like domain containing E3 ubiquitin protein ligase. (374 aa)
	MUL1	Mitochondrial E3 ubiquitin protein ligase 1. (352 aa)
	F2RL1	F2R like trypsin receptor 1. (397 aa)
	NOL3	Nucleolar protein 3. (217 aa)
	ECM1	Extracellular matrix protein 1. (564 aa)
	PIAS4	Protein inhibitor of activated STAT 4. (514 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type. (388 aa)
	NLRC5	NLR family CARD domain containing 5. (1868 aa)
	PELI3	E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (445 aa)
	M3XSY8_MUSPF	Uncharacterized protein. (300 aa)
	M3XSY7_MUSPF	Uncharacterized protein. (242 aa)
	STAP1	Signal transducing adaptor family member 1. (287 aa)
	STAT2	Signal transducer and activator of transcription. (848 aa)
	XIAP	X-linked inhibitor of apoptosis. (497 aa)
	M3XP26_MUSPF	Uncharacterized protein. (265 aa)
	M3XM81_MUSPF	Uncharacterized protein; Belongs to the MT-A70-like family. (582 aa)
	DCST1	DC-STAMP domain containing 1. (625 aa)
	BIRC7	Baculoviral IAP repeat containing 7. (300 aa)
	SIGIRR	Single Ig and TIR domain containing. (410 aa)
	GAS6	Growth arrest specific 6. (541 aa)
	IL1RN	Interleukin-1. (158 aa)
	IL36RN	Interleukin-1. (156 aa)
	YTHDF3	YTH N6-methyladenosine RNA binding protein 3. (585 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (1298 aa)
	NR1H4	Nuclear receptor subfamily 1 group H member 4. (472 aa)
	IL1R2	Interleukin 1 receptor type 2. (414 aa)
	SLIT3	Slit guidance ligand 3. (1391 aa)
	TRAIP	TRAF interacting protein. (469 aa)
	APOA1	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. (323 aa)
	CACTIN	Cactin, spliceosome C complex subunit. (752 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (244 aa)
	CYLD	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (953 aa)
	PALM3	Paralemmin 3. (627 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (230 aa)
	TREML1	Triggering receptor expressed on myeloid cells like 1. (314 aa)
	ISG15	ISG15 ubiquitin like modifier. (184 aa)
	M3YXN1_MUSPF	Uncharacterized protein. (506 aa)
	PADI2	Peptidyl arginine deiminase 2. (665 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAR	ISG15	ENSMPUP00000007083	ENSMPUP00000013820	Adenosine deaminase RNA specific.	ISG15 ubiquitin like modifier.	0.452
ADAR	SAMHD1	ENSMPUP00000007083	ENSMPUP00000017657	Adenosine deaminase RNA specific.	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1.	0.521
ADAR	STAT2	ENSMPUP00000007083	ENSMPUP00000001419	Adenosine deaminase RNA specific.	Signal transducer and activator of transcription.	0.446
ADIPOQ	CAV1	ENSMPUP00000003314	ENSMPUP00000007166	Adiponectin, C1Q and collagen domain containing.	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	0.410
BIRC7	CYLD	ENSMPUP00000008063	ENSMPUP00000003166	Baculoviral IAP repeat containing 7.	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family.	0.484
BIRC7	XIAP	ENSMPUP00000008063	ENSMPUP00000001342	Baculoviral IAP repeat containing 7.	X-linked inhibitor of apoptosis.	0.927
CACTIN	TTLL12	ENSMPUP00000004002	ENSMPUP00000016190	Cactin, spliceosome C complex subunit.	Tubulin tyrosine ligase like 12.	0.448
CAV1	ADIPOQ	ENSMPUP00000007166	ENSMPUP00000003314	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Adiponectin, C1Q and collagen domain containing.	0.410
CNOT7	YTHDF2	ENSMPUP00000017861	ENSMPUP00000015389	CCR4-NOT transcription complex subunit 7.	YTH N6-methyladenosine RNA binding protein 2.	0.444
CNOT7	YTHDF3	ENSMPUP00000017861	ENSMPUP00000009782	CCR4-NOT transcription complex subunit 7.	YTH N6-methyladenosine RNA binding protein 3.	0.635
CYLD	BIRC7	ENSMPUP00000003166	ENSMPUP00000008063	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family.	Baculoviral IAP repeat containing 7.	0.484
CYLD	ISG15	ENSMPUP00000003166	ENSMPUP00000013820	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family.	ISG15 ubiquitin like modifier.	0.512
CYLD	XIAP	ENSMPUP00000003166	ENSMPUP00000001342	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family.	X-linked inhibitor of apoptosis.	0.633
GAS6	TREM2	ENSMPUP00000009127	ENSMPUP00000013551	Growth arrest specific 6.	Triggering receptor expressed on myeloid cells 2.	0.465
GAS6	TREML1	ENSMPUP00000009127	ENSMPUP00000013574	Growth arrest specific 6.	Triggering receptor expressed on myeloid cells like 1.	0.465
IL1R2	IL1RN	ENSMPUP00000012138	ENSMPUP00000009465	Interleukin 1 receptor type 2.	Interleukin-1.	0.964
IL1R2	IL36RN	ENSMPUP00000012138	ENSMPUP00000009495	Interleukin 1 receptor type 2.	Interleukin-1.	0.688
IL1RN	IL1R2	ENSMPUP00000009465	ENSMPUP00000012138	Interleukin-1.	Interleukin 1 receptor type 2.	0.964
IL36RN	IL1R2	ENSMPUP00000009495	ENSMPUP00000012138	Interleukin-1.	Interleukin 1 receptor type 2.	0.688
ISG15	ADAR	ENSMPUP00000013820	ENSMPUP00000007083	ISG15 ubiquitin like modifier.	Adenosine deaminase RNA specific.	0.452