node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AREG | ESR1 | ENSMPUP00000009027 | ENSMPUP00000010404 | Amphiregulin. | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | 0.409 |
AREG | SPRY2 | ENSMPUP00000009027 | ENSMPUP00000018649 | Amphiregulin. | Sprouty RTK signaling antagonist 2. | 0.538 |
BMP4 | FGF1 | ENSMPUP00000005423 | ENSMPUP00000007888 | Bone morphogenetic protein 4. | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] | 0.414 |
BMP4 | FGF10 | ENSMPUP00000005423 | ENSMPUP00000014301 | Bone morphogenetic protein 4. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.818 |
BMP4 | SOX9 | ENSMPUP00000005423 | ENSMPUP00000014195 | Bone morphogenetic protein 4. | SRY-box transcription factor 9. | 0.589 |
BMP4 | SPRY2 | ENSMPUP00000005423 | ENSMPUP00000018649 | Bone morphogenetic protein 4. | Sprouty RTK signaling antagonist 2. | 0.426 |
BMP4 | WNT11 | ENSMPUP00000005423 | ENSMPUP00000008719 | Bone morphogenetic protein 4. | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | 0.418 |
ESR1 | AREG | ENSMPUP00000010404 | ENSMPUP00000009027 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Amphiregulin. | 0.409 |
ESR1 | M3YU90_MUSPF | ENSMPUP00000010404 | ENSMPUP00000014900 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.981 |
ESR1 | TGFB1 | ENSMPUP00000010404 | ENSMPUP00000017540 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] | 0.531 |
FGF1 | BMP4 | ENSMPUP00000007888 | ENSMPUP00000005423 | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] | Bone morphogenetic protein 4. | 0.414 |
FGF1 | FGF10 | ENSMPUP00000007888 | ENSMPUP00000014301 | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.599 |
FGF1 | TGFB1 | ENSMPUP00000007888 | ENSMPUP00000017540 | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] | 0.741 |
FGF10 | BMP4 | ENSMPUP00000014301 | ENSMPUP00000005423 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Bone morphogenetic protein 4. | 0.818 |
FGF10 | FGF1 | ENSMPUP00000014301 | ENSMPUP00000007888 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] | 0.599 |
FGF10 | SOX9 | ENSMPUP00000014301 | ENSMPUP00000014195 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | SRY-box transcription factor 9. | 0.532 |
FGF10 | TGFB1 | ENSMPUP00000014301 | ENSMPUP00000017540 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] | 0.656 |
M3Y377_MUSPF | PTK7 | ENSMPUP00000005778 | ENSMPUP00000013001 | NTR domain-containing protein. | Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. | 0.421 |
M3Y377_MUSPF | SFRP2 | ENSMPUP00000005778 | ENSMPUP00000005451 | NTR domain-containing protein. | Secreted frizzled related protein 2. | 0.821 |
M3Y377_MUSPF | WNT11 | ENSMPUP00000005778 | ENSMPUP00000008719 | NTR domain-containing protein. | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | 0.933 |