STRINGSTRING
ANAPC7 ANAPC7 ANAPC5 ANAPC5 M3XSL4_MUSPF M3XSL4_MUSPF RAD21 RAD21 TOM1L2 TOM1L2 EDN1 EDN1 CD28 CD28 ZWILCH ZWILCH KNTC1 KNTC1 RB1 RB1 NSMCE2 NSMCE2 MTBP MTBP XRCC3 XRCC3 CDC23 CDC23 M3YD28_MUSPF M3YD28_MUSPF CDC16 CDC16 EREG EREG EPGN EPGN BTC BTC M3YBR7_MUSPF M3YBR7_MUSPF INSR INSR M3YAG0_MUSPF M3YAG0_MUSPF AURKB AURKB CDC27 CDC27 M3Y8U7_MUSPF M3Y8U7_MUSPF TGFA TGFA CAV2 CAV2 USP44 USP44 SMPD3 SMPD3 CHEK1 CHEK1 BMP7 BMP7 ATM ATM IGF2 IGF2 INS INS TRIP13 TRIP13 PCID2 PCID2 ANAPC15 ANAPC15 BORA BORA FBXO5 FBXO5 FBXW5 FBXW5 M3YIU0_MUSPF M3YIU0_MUSPF M3YJ43_MUSPF M3YJ43_MUSPF DYNC1LI1 DYNC1LI1 IGF1 IGF1 NDC80 NDC80 DMRT1 DMRT1 HOXA13 HOXA13 PSMG2 PSMG2 BMP4 BMP4 LRP5 LRP5 ZW10 ZW10 M3XXC5_MUSPF M3XXC5_MUSPF KLHL22 KLHL22 CDCA2 CDCA2 BUB3 BUB3 M3XTP7_MUSPF M3XTP7_MUSPF TPR TPR PLK1 PLK1 APC APC SH2B1 SH2B1 MAD2L1BP MAD2L1BP SPDL1 SPDL1 CUL9 CUL9 CUL7 CUL7 BIRC5 BIRC5 AFMID AFMID PDGFB PDGFB SPHK1 SPHK1 GEN1 GEN1 LOC101676420 LOC101676420 ZNF207 ZNF207 NME6 NME6 FBXO43 FBXO43 TOM1L1 TOM1L1 RCC1 RCC1 OBSL1 OBSL1 CUL3 CUL3 KIF20B KIF20B MAD2L1 MAD2L1 MAD1L1 MAD1L1 TTK TTK HASPIN HASPIN NUP62 NUP62 CCDC8 CCDC8 M3Z7E4_MUSPF M3Z7E4_MUSPF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ANAPC7Anaphase promoting complex subunit 7. (598 aa)
ANAPC5Anaphase promoting complex subunit 5. (711 aa)
M3XSL4_MUSPFUncharacterized protein. (443 aa)
RAD21RAD21 cohesin complex component. (631 aa)
TOM1L2Target of myb1 like 2 membrane trafficking protein; Belongs to the TOM1 family. (506 aa)
EDN1Endothelin 1. (202 aa)
CD28CD28 molecule. (255 aa)
ZWILCHZwilch kinetochore protein. (589 aa)
KNTC1Kinetochore associated 1. (2207 aa)
RB1RB transcriptional corepressor 1. (948 aa)
NSMCE2NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (275 aa)
MTBPMDM2 binding protein. (893 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (349 aa)
CDC23Cell division cycle 23. (590 aa)
M3YD28_MUSPFUncharacterized protein. (1086 aa)
CDC16Cell division cycle 16. (605 aa)
EREGEpiregulin. (161 aa)
EPGNEpithelial mitogen. (153 aa)
BTCBetacellulin. (185 aa)
M3YBR7_MUSPFUncharacterized protein. (441 aa)
INSRTyrosine-protein kinase receptor. (1352 aa)
M3YAG0_MUSPFBUB1 N-terminal domain-containing protein. (1062 aa)
AURKBAurora kinase B; Belongs to the protein kinase superfamily. (344 aa)
CDC27Cell division cycle 27. (825 aa)
M3Y8U7_MUSPFCDT1 domain-containing protein. (347 aa)
TGFATransforming growth factor alpha. (158 aa)
CAV2Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (B [...] (162 aa)
USP44Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (711 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (658 aa)
CHEK1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3057 aa)
IGF2Insulin like growth factor 2. (192 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (109 aa)
TRIP13Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family. (434 aa)
PCID2PCI domain containing 2. (390 aa)
ANAPC15Anaphase promoting complex subunit 15. (132 aa)
BORABORA aurora kinase A activator. (602 aa)
FBXO5F-box protein 5. (386 aa)
FBXW5F-box and WD repeat domain containing 5. (566 aa)
M3YIU0_MUSPFRING-type domain-containing protein. (84 aa)
M3YJ43_MUSPFLeucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. (339 aa)
DYNC1LI1Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (524 aa)
IGF1Insulin like growth factor 1. (153 aa)
NDC80NDC80 kinetochore complex component. (642 aa)
DMRT1Doublesex and mab-3 related transcription factor 1. (324 aa)
HOXA13Homeobox A13. (259 aa)
PSMG2Proteasome assembly chaperone 2; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. Belongs to the PSMG2 family. (264 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
LRP5Uncharacterized protein. (1465 aa)
ZW10Zw10 kinetochore protein. (779 aa)
M3XXC5_MUSPFNsp1_C domain-containing protein. (267 aa)
KLHL22Kelch like family member 22. (634 aa)
CDCA2Cell division cycle associated 2. (1055 aa)
BUB3BUB3 mitotic checkpoint protein. (328 aa)
M3XTP7_MUSPFFHA domain-containing protein. (2369 aa)
TPRTranslocated promoter region, nuclear basket protein. (2439 aa)
PLK1Serine/threonine-protein kinase PLK. (542 aa)
APCAPC regulator of WNT signaling pathway. (2862 aa)
SH2B1SH2B adaptor protein 1. (757 aa)
MAD2L1BPMAD2L1 binding protein. (281 aa)
SPDL1Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. (603 aa)
CUL9Cullin 9; Belongs to the cullin family. (2524 aa)
CUL7Cullin 7; Belongs to the cullin family. (1687 aa)
BIRC5Baculoviral IAP repeat containing 5. (142 aa)
AFMIDKynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (307 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (242 aa)
SPHK1Sphingosine kinase 1. (386 aa)
GEN1GEN1 Holliday junction 5' flap endonuclease. (907 aa)
LOC101676420Protein kinase domain-containing protein. (726 aa)
ZNF207Zinc finger protein 207. (534 aa)
NME6Nucleoside diphosphate kinase. (226 aa)
FBXO43F-box protein 43. (563 aa)
TOM1L1Target of myb1 like 1 membrane trafficking protein; Belongs to the TOM1 family. (476 aa)
RCC1Regulator of chromosome condensation 1. (451 aa)
OBSL1Obscurin like 1. (1896 aa)
CUL3Cullin 3; Belongs to the cullin family. (746 aa)
KIF20BKinesin family member 20B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1768 aa)
MAD2L1Mitotic arrest deficient 2 like 1. (205 aa)
MAD1L1Mitotic arrest deficient 1 like 1. (737 aa)
TTKTTK protein kinase. (856 aa)
HASPINHistone H3 associated protein kinase. (767 aa)
NUP62Nucleoporin 62. (527 aa)
CCDC8Coiled-coil domain containing 8. (497 aa)
M3Z7E4_MUSPFUncharacterized protein. (1085 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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