(33 nodes) Negative regulation of cellular carbohydrate metabolic process network (Mustela putorius)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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co-expression

protein homology

Your Input:
	TIGAR	TP53 induced glycolysis regulatory phosphatase. (270 aa)
	SLC4A1	Anion exchange protein. (924 aa)
	M3YE86_MUSPF	Uncharacterized protein. (766 aa)
	NCOR1	Nuclear receptor corepressor 1. (2510 aa)
	STAT3	Signal transducer and activator of transcription. (770 aa)
	IER3	Immediate early response 3. (155 aa)
	CRY1	Cryptochrome circadian regulator 1. (587 aa)
	GIT1	GIT ArfGAP 1. (708 aa)
	MST1	Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (711 aa)
	INPP5K	Inositol polyphosphate-5-phosphatase K. (473 aa)
	GCK	Phosphotransferase. (473 aa)
	EP300	E1A binding protein p300. (2425 aa)
	COX11	Cytochrome c oxidase copper chaperone COX11. (279 aa)
	M3YUN0_MUSPF	C1q domain-containing protein. (306 aa)
	ENPP1	Ectonucleotide pyrophosphatase/phosphodiesterase 1. (847 aa)
	C1QTNF12	C1q and TNF related 12. (305 aa)
	FLCN	UDENN FLCN/SMCR8-type domain-containing protein. (579 aa)
	ERFE	Erythroferrone. (402 aa)
	HDAC4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1083 aa)
	PASK	PAS domain containing serine/threonine kinase. (1341 aa)
	LEPR	Leptin receptor. (1164 aa)
	ACTN3	Actinin alpha 3 (gene/pseudogene). (904 aa)
	SERPINA12	Serpin family A member 12; Belongs to the serpin family. (414 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (244 aa)
	DDIT4	DNA damage inducible transcript 4. (230 aa)
	M3XZQ7_MUSPF	Ubiquitin-like domain-containing protein. (311 aa)
	M3XZR5_MUSPF	RBR-type E3 ubiquitin transferase. (115 aa)
	SIRT6	Sirtuin 6. (359 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (109 aa)
	FBP1	Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (338 aa)
	FAM3C	Family with sequence similarity 3 member C. (227 aa)
	CBFA2T3	CBFA2/RUNX1 partner transcriptional co-repressor 3. (630 aa)
	MIDN	Midnolin. (460 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIPOQ	INS	ENSMPUP00000003314	ENSMPUP00000005593	Adiponectin, C1Q and collagen domain containing.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.771
ADIPOQ	LEPR	ENSMPUP00000003314	ENSMPUP00000000731	Adiponectin, C1Q and collagen domain containing.	Leptin receptor.	0.526
CBFA2T3	NCOR1	ENSMPUP00000007559	ENSMPUP00000010116	CBFA2/RUNX1 partner transcriptional co-repressor 3.	Nuclear receptor corepressor 1.	0.527
DDIT4	EP300	ENSMPUP00000004046	ENSMPUP00000016323	DNA damage inducible transcript 4.	E1A binding protein p300.	0.743
EP300	DDIT4	ENSMPUP00000016323	ENSMPUP00000004046	E1A binding protein p300.	DNA damage inducible transcript 4.	0.743
EP300	HDAC4	ENSMPUP00000016323	ENSMPUP00000000123	E1A binding protein p300.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.520
EP300	NCOR1	ENSMPUP00000016323	ENSMPUP00000010116	E1A binding protein p300.	Nuclear receptor corepressor 1.	0.806
EP300	STAT3	ENSMPUP00000016323	ENSMPUP00000010432	E1A binding protein p300.	Signal transducer and activator of transcription.	0.983
FBP1	TIGAR	ENSMPUP00000006610	ENSMPUP00000009248	Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family.	TP53 induced glycolysis regulatory phosphatase.	0.948
GCK	INS	ENSMPUP00000018089	ENSMPUP00000005593	Phosphotransferase.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.716
GCK	TIGAR	ENSMPUP00000018089	ENSMPUP00000009248	Phosphotransferase.	TP53 induced glycolysis regulatory phosphatase.	0.430
HDAC4	EP300	ENSMPUP00000000123	ENSMPUP00000016323	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	E1A binding protein p300.	0.520
HDAC4	NCOR1	ENSMPUP00000000123	ENSMPUP00000010116	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Nuclear receptor corepressor 1.	0.602
HDAC4	STAT3	ENSMPUP00000000123	ENSMPUP00000010432	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Signal transducer and activator of transcription.	0.404
INS	ADIPOQ	ENSMPUP00000005593	ENSMPUP00000003314	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Adiponectin, C1Q and collagen domain containing.	0.771
INS	GCK	ENSMPUP00000005593	ENSMPUP00000018089	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Phosphotransferase.	0.716
INS	LEPR	ENSMPUP00000005593	ENSMPUP00000000731	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Leptin receptor.	0.791
INS	STAT3	ENSMPUP00000005593	ENSMPUP00000010432	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Signal transducer and activator of transcription.	0.667
LEPR	ADIPOQ	ENSMPUP00000000731	ENSMPUP00000003314	Leptin receptor.	Adiponectin, C1Q and collagen domain containing.	0.526
LEPR	INS	ENSMPUP00000000731	ENSMPUP00000005593	Leptin receptor.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.791